Video: Acute Versus Chronic Toxicity
Next, you will design two experiments to measure the effectiveness of aspirin: one to evaluate aspirin as a pain reliever, and one to evaluate aspirin in heart attack prevention. You will not actually carry out these experiments, just design them.
Remember: a dose-response curve depends entirely on the biological response that you choose to measure. Now consider that acute doses are very different from chronic doses.
We’ve discussed median lethal dose and median effective dose. What other acute effects could you measure for aspirin? How would you make those measurements in human patients?
We’ve discussed lowered cardiovascular risk in patients who take a low daily aspirin dose. What other chronic effects could you measure for aspirin? How would you make those measurements in human patients?