Diagnostic Evaluation of Trace Mineral Status in the Bovine Fetus
Primary Investigator:
Dr. Robert Van Saun
Contributing Investigators:
Robert H. Poppenga (Co-Primary)
Project Description:
The
objective of this study is to establish diagnostic reference values for
interpreting fetal hepatic trace mineral concentrations.
Objectives:
The
objective of this study is to establish diagnostic reference values for
interpreting fetal hepatic trace mineral concentrations. Nutritional
disease is implicated in all major factors contributing to fetal and
newborn calf diseases and death. Adult mineral values are often used to
interpret fetal values, but due to inherent differences in mineral
metabolism and liver dry matter, potential role of minerals in fetal
calf disease is under or mis-diagnosed. Aims of this study are to
investigate the roles of liver dry matter and fetal age on mineral
concentrations and compare hepatic mineral concentrations between
abortion and abattoir samples. Paired liver samples (n=150) will be
collected at an abattoir from pregnant cows and their fetus along with
fetal blood. Fetal age will be determined by measured crown-to-rump
length. Additional fetal liver samples (n=50) will be collected from
abortion cases submitted to PADLS. Concentration of 17 minerals will be
measured by ICP/MS in all liver and blood samples. Dry matter content
of maternal and fetal liver will be determined. Population statistics
in conjunction with maternal status will be used to establish fetal
mineral criteria. Fetal mineral status will be related to abortion
cause using relative risk statistics. Establishment of
fetal-based diagnostic criteria to evaluate mineral status will
increase abortion diagnostic capabilities of PADLS as well as providing
useful information to improve mineral feeding practices of the pregnant
cow to prevent fetal loss and neonatal disease problems.
Project Citations and Files:
Prediction of Bovine Fetal Hepatic Dry Matter Content |
Van Saun, R.J., Poppenga, R. Prediction of bovine fetal hepatic dry matter content. Proceedings XXIV World Buiatrics Congress, Nice, France, October 15-19, 2006 (Abstract #80/PS1-015 [CD-ROM Proceedings]). |
Variation in Bovine Fetal Hepatic Mineral Concentration |
Van Saun, R.J., Poppenga, R. Variation in bovine fetal hepatic mineral concentration. Proceedings XXIV World Buiatrics Congress, Nice, France, October 15-19, 2006 (Abstract #81/PS3-014 [CD-ROM Proceedings]). |
Factors influencing bovine maternal and fetal hepatic mineral concentrations. |
Van Saun, R.J., R.H. Poppenga. Factors influencing bovine maternal and fetal hepatic mineral concentrations. Pg. 284, In: Proceedings 13th International Conference on Production Diseases in Farm Animals, M. Fürll (ed.), Leipzig, Germany, July 29-August 4, 2007. |
Breed effects on bovine fetal and maternal hepatic mineral concentrations |
Van Saun, R.J., R.H. Poppenga. Breed effects on bovine fetal and maternal hepatic mineral concentrations. Pg. 285, In: Proceedings 13th International Conference on Production Diseases in Farm Animals, M. Fürll (ed.), Leipzig, Germany, July 29-August 4, 2007. |
Comparisons between bovine maternal and fetal hepatic mineral content |
Van Saun, R.J., R.H. Poppenga. Comparisons between bovine maternal and fetal hepatic mineral content. Pg. 287, In: Proceedings 13th International Conference on Production Diseases in Farm Animals, M. Fürll (ed.), Leipzig, Germany, July 29-August 4, 2007. |
