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Molecular Toxicology and Carcinogenesis

Faculty in the Molecular Toxicology are researching a wide range of chemicals and conditions, including dioxins, tobacco, pesticides, breast cancer and neurological disorders.

Molecular Toxicology and Carcinogenesis researchers working in the Department of Veterinary and Biomedical Sciences at Penn State.

The Center was formed in 1997 to develop and expand programs in toxicology and carcinogenesis at Penn State. Over the past ten years the Center has fostered the development of graduate and undergraduate programs in toxicology.

Our research focus is on mechanisms of cancer development in squamous epithelia. We focus primarily on the role of Transforming Growth Factor Beta (TGFβ) and its signaling pathway in the regulation of tumor promotion and progression.

The research area of our laboratory is that of Molecular Toxicology. Our research centers on the study of human variability in chemical detoxication, an area termed 'toxicogenomics.'

The primary focus of the Perdew Research Group is researching how biological systems respond to exogenous chemicals.

The focus of our laboratory is the determine the biological roles of PPARs in toxicology, carcinogenesis and homeostasis, with a keen interest in identification and characterization of target genes regulated by these receptors.

Studies in our laboratory are focused around various cellular and molecular mechanisms by which micronutrients such as selenium and other products of natural origin alter the host response and immune function in response to oxidative stress caused by environmental toxicants and pathogens.

Research in the Vanden Heuvel laboratory is in the emerging disciplines of Molecular Toxicology and Nutrigenomics. We are interested in nuclear receptors (NR) such as the peroxisome proliferator-activated receptors (PPARs) that play important roles in both toxicology and nutrition.