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The Interleukin(IL)-1 receptor signaling pathway is critical to the survival of mice following B. pertussis infection.

Posted: February 7, 2011

Bordetella pertussis, the bacteria that causes the disease whooping cough in humans, requires various aspects of the immune response for efficient clearance from its host. Using the mouse model, a team of CMIID researchers led by associate professor Eric Harvill and Genetics graduate student Xuqing Zhang determined that a chemical pathway involved in inflammatory responses, known as the Interleukin(IL)-1 receptor signaling pathway, is critical to the survival of mice following B. pertussis infection. 

 

"Interleukin-1 Receptor Signaling Is Required To Overcome the Effects of Pertussis Toxin and for Efficient Infection or Vaccination-Induced Immunity Against Bordetella pertussis."