Recent refereed articles


Chen J., A. Waddell, Y. Lin, and M.T. Cantorna 2014  Innate lymphoid cell driven dysbiosis and colonization resistance to Citrobacter rodentium in vitamin D receptor knockout mice.  Mucosal Immunol.  In press.

Kaushal, N., A.K. Kudva, A.D. Patterson, C. Chiaro, M.J. Kennett, D. Desai, S. Amin, B.A. Carlson, M.T. Cantorna and K.S. Prabhu.  2014.  Crucial role of macrophage selenoproteins in experimental colitis.  J. Immunol.  193:3683-3692.

He X., J. Yan, X. Zhu, Q. Wang, W. Pang, Z. Qi , M. Wang, E. Luo , D. M. Parker, M.T. Cantorna, L. Cui, Y. Cao. 2014.  Vitamin D inhibits the occurrence of experimental cerebral malaria in mice by suppressing the host inflammatory response.  J Immunol.  193:1314-1323.

Cantorna M.T., A.Waddell. 2014. The vitamin D receptor turns off chronically activated T cells. Ann. N. Y. Acad. Sci. 1317:70-75.

Cantorna M.T., K. McDaniel, S. Bora, J. Chen, J. James. 2014.  Vitamin D, immune regulation, the microbiota and inflammatory bowel disease.  Exp. Biol. Med. in press.

Chen J., D. Bruce D, M.T. Cantorna. 2014. Vitamin D receptor expression controls proliferation of naïve CD8+ T cells and development of CD8 mediated gastrointestinal inflammation.  BMC Immunol. 15:6.

Ooi, J.H., A. Waddell, Y. Lin, I. Albert, L.T. Rust, V. Holden, and M.T. Cantorna.  2014. Dominant effects of the diet on the microbiome and the local and systemic immunse response in mice. Plos One 9:e86366.

Restori, K.H., K.L. McDaniel, A.E. Wray, M.T. Cantorna, and A.C. Ross. 2014.  Streptococcus pneumoniae-Induced Pneumonia and Citrobacter rodentium-Induced Gut Infection Differentially Alter Vitamin A Concentrations in the Lung and Liver of Mice. J Nutr. 144:392-398.

Ooi, J.H., K.L. McDaniel, V. Weaver and M.T. Cantorna.  2014.  Murine CD8+ T cells but not macrophages express the vitamin D 1α-hydroxylase.  J. Nutr. Biochem.  25:58-65.


Ooi, J.H., J. Li, C.J. Rogers, and M.T. Cantorna.  2013.  Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced colitis. J. Nutr. 143:1679-1686.

Pinkerton, M., V.Chinchilli, E. Banta, T. Craig, A. August, R. Bascom, M.T. Cantorna, E. Harvill, and F.T. Ishmael.  2013.  Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults.  J. Allergy Clin. Immunol.  132:217-219.

Yang, L., V. Weaver, J.P.Smith, S. Bingaman, T. J. Hartman, and M.T. Cantorna.  2013.  Therapeutic effect of vitamin D supplementation in a pilot study of Crohn’s patients.  Clin Transl Gastroenterol. 4:e33.

Varshney, J., J.H. Ooi, B.M. Jayarao, I. Albert, J. Fisher, R.L. Smith, A.D. Patterson and M.T. Cantorna. 2013.  White button mushrooms increase microbial diversity and accelerate the resolution of Citrobacter rodentium infection in mice. J. Nutr 143:526-532.


Cantorna, M.T.  2012 Vitamin D, multiple sclerosis and inflammatory bowel diseases.  Arch Biochem Biophys.  523:103-106.

Ooi, J.H., J. Chen and M.T. Cantorna.  2012.  Vitamin D regulation of immune function in the gut: Why do T cells have vitamin D receptors?  Mol. Aspects Med.  33:77-82.

Whitcomb, J.P., M. DeAgostino, M. Ballentine, J. Fu, M. Tenniswood, J. Walsh, M.T. Cantorna, and M.A. McDowell.  2012 The role of vitamin D and vitamin D receptor in immunity to Leishmania major .infection. J. Parasitol. Res. 2012:134645.

Cantorna, M.T., J. Zhao, and L. Yang.  2012.  Vitamin D, invariant natural killer T-cells and experimental autoimmune disease.  Proc. Nutr. Soc. 71:62-66.


Yu, S., J. Zhoa, and M.T. Cantorna.  2011.  Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation.  J. Immunol.  187:4907-4912.

Bruce, D., S. Yu, J. H. Ooi, and M. T. Cantorna. 2011.  Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling.  Inter. Immunol.  8:519-528.

Bruce, D. and M. T. Cantorna.  2011. Intrinsic requirement for the vitamin D receptor for the development of CD8αα expressing T cells.  J. Immunol. 186:2819-2825.

Yu, S. and M.T. Cantorna 2011  Epigenetic regulation of invariant NKT cells following in utero vitamin D deficiency in mice.  J. Immunol.186:1384-1390.

Qi Q., Xia M., Bai Y., Yu S., Cantorna M.T., and August A.  2011  Interleukin-2 inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell.  J. Biol. Chem. 286:138-146.

Bruce, D. and M.T. Cantorna 2011. Vitamin D and Inflammatory Bowel Disease In Vitamin D, Third ed.  Feldman, D., Pike, W.J., and Adams, J.S. (Eds.), Academic Press, London, pp. 1879-2890.

Cantorna, M.T. 2011 Why do T cells express the vitamin D receptor?  Ann N Y Acad Sci. 1217:77-82.


Bruce, D., J.H. Ooi, S. Yu, and M.T. Cantorna 2010  Vitamin D and host resistance to infection?  Putting the cart in front of the horse.  Exp Biol Med  235:921-927.

Cantorna, M. T.  2010 Mechanisms underlying the effect of vitamin D on the immune system. Proc Nutr Soc, 69:286-289.


Yu, S., V. Weaver, K. Martin, and M.T. Cantorna.  2009   The effects of whole mushrooms during inflammation.  BMC Immunol 10:12.

Bruce, D, J. P. Whitcomb, A. August, M. A. McDowell and Cantorna, M.T.  2009 Elevated nonspecific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice.  Inter Immunol. 2:113-122.


Yu S., D. Bruce, M. Froicu, V. Weaver and Cantorna, M.T., 2008. Failure of T cell homing, reduced CD4/CD8aa intraepithelial lymphocytes and inflammation in the gut of vitamin D receptor KO mice. Proc. Natl. Acad. Sci. USA 105:20834-20839.

Cantorna, M.T., S. Yu, and D. Bruce.  2008.  The paradoxical effects of vitamin D on type-1 mediated immunity.  Mol. Asp. Med. 29:369-375.

Yu, S. and M. T. Cantorna.  2008 The vitamin D receptor expression is required for iNKT cell development. Proc. Natl. Acad. Sci. USA 105:5207-5212.

Cantorna, M. T.  2008  Vitamin D and multiple sclerosis: An update. Nutr Rev S135-S138.


Froicu, M., and M. T. Cantorna.  2007 Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol 8:5.

Wittke, A., A. Chang, M. Froicu, O. F. Harandi, V. Weaver, A. August, R. F. Paulson and M. T. Cantorna  2007.  Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation.  Arch. Biochem. Biophy. 460:306-313.


Cantorna, M.T.  2006.  Vitamin D and its role in immunology: Multiple sclerosis, and inflammatory bowel disease. Prog. Biophy. Mol. Biol.  92:60-64.

August, A., C. Mueller, V. Weaver, T.A. Polanco, E.R. Walsh, and M.T. Cantorna  2006.  Nutrients, Nuclear Receptors, Inflammation, Immunity Lipids, PPAR, and Allergic Asthma.  J. Nutr. 136:695-696.

Froicu, M., Y. Zhu, and M.T. Cantorna.  2006 Vitamin D receptor signaling is required to control Th1 driven gastrointestinal immunity in IL-10 knockout mice. Immunol.  117:310-318.

Cantorna, M.T. and B.D. Mahon.  2005.  D-hormone and the immune system. J. Rheumatol. 32, Suppl 76:11-20.

Zhu, Y, B.D. Mahon, M. Froicu, and M.T. Cantorna.  2005. Calcium and 1,25 dihydroxyvitamin D3 target the TNFa pathway to suppress experimental inflammatory bowel disease. Eur. J. Immunol.  35:217-224.

Cantorna, M, and B.D. Mahon.  2004.  Vitamin D and autoimmunity:  Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp. Biol. Med. 229:1136-1142.

Cantorna, M.T., Y. Zhu, M. Froicu, and A. Wittke.  2004.  Vitamin D and the immune system. Amer. J Clin. Nutr.  80:1717S-1720S.

Wittke, A., V. Weaver, B.D. Mahon, A. August, and M.T. Cantorna. 2004. Vitamin D receptor deficient mice fail to develop experimental asthma. J. Immunol.  173:3432-3436.

Froicu, M., V. Weaver, T.A. Wynn, J. Welch,M. McDowell, and M.T. Cantorna.  2003.  A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases.  Mol. Endo. 17:2386-2392.

Mueller, C., V. Weaver, J. Vanden Heuvel, A. August, and M.T. Cantorna.  2003.  Peroxisome proliferator activated receptor-gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch. Biochem. Biophy. 418:186-196.

Mahon, B.D., A. Wittke, V. Weaver, and M.T. Cantorna. 2003. The targets of vitamin D depend on the differentiation and activation status of the CD4 positive T cells. J Biol Chem. 89:922-932.

Grant, S., J. Weisinger, J. Beard, and M.T. Cantorna.  2003.  Iron deficient mice fail to develop autoimmune encephalomyelitis. J Nutr. 133:2635-2638.

Mahon, B.D., S.A. Gordon, J. Cruz, F. Cosman, and M.T. Cantorna.  2003.  Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J. Neuroimmunol.  134:128-132.

Bemiss, C., B.D. Mahon, A. Henry, V. Weaver, and M.T. Cantorna.  2002.  Interleukin-2 is both an in vivo and in vitro target of vitamin D in the immune system.  Arch. Biochem. Biophy. 402:249-254.

DeLuca, H.F., and M.T. Cantorna.  2001 Vitamin D:  It’s role and uses in immunology. FASEB Journal. 15:2579-2585.

Cantorna, M.T., C. Munsick, C. Bemiss, and B.D. Mahon.  2000.  1,25-dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J. Nutr. 130:2648-2652.

Cantorna, M.T., J. Humpal-Winter, and H.F. DeLuca.  2000.  In vivo upregulation of IL-4 is one mechanism underlying the immunoregulatory effects of 1,25-dihydroxyvitamin D3. Arch. Biochem. Biophy. 377:135-138.

Veldman, C.M., M. T. Cantorna, and H. F. DeLuca. 2000. Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system. Arch. Biochem. Biophy. 374:334-338.

Cantorna, M. T.  2000.  Vitamin D and autoimmunity:  Is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc. Soc. Exp. Biol. Med, 223:230-233.

Cantorna, M.T., and H.F. DeLuca.  1999.  Dietary calcium and 1,25-dihydroxy-cholecalciferol are major determinants in the prevention of EAE in mice. J. Nutr. 129:1966-1971.

Cantorna, M.T., D.A. Hullett, C. Redaelli, C. Brandt, J. Humpal-Winter, H. Solinger, and H.F. DeLuca.  1998.  1,25-dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density.  Transplantation.  66:828-831. 

Hullett, D.A., M.T. Cantorna, C. Redaelli, J. Humpal-Winter, C. E. Hayes, H. Solinger, and H.F. DeLuca.  1998.  Prolongation of allograft survival by 1,25-dihydroxyvitamin.  Transplantation.  66:824-828.

Cantorna, M.T., B. Woodward, C.E. Hayes, and H.F. DeLuca.  1998.  1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-b1 and IL-4.  J. Immunol.  160:5314-5319.

Cantorna, M.T., C.E. Hayes, and H.F. DeLuca.  1998. 1,25-dihydroxycholecalci-ferol inhibits the progression of arthritis in murine models of human arthritis.  J. Nutr. 128:68-72.

Hayes, C.E., M.T. Cantorna, and H.F. DeLuca.  1997.  Vitamin D and multiple sclerosis.  Proc. Soc. Exp. Biol. Med.  216:21-27.

Cantorna, M.T., C.E. Hayes, and H.F. DeLuca.  1996.  1,25-dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis.  Proc. Natl. Acad. Sci. USA.  93:7861-7864.

Cantorna, M.T., and C.E. Hayes.  1996.  Vitamin A deficiency exacerbates murine Lyme arthritis.  J. Infect. Dis.  174:747-751.

Cantorna, M.T., F. E. Nashold, T.Y. Chun, and C.E. Hayes.  1996.  Vitamin A downregulation of interferon-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway.  J. Immunol.  156:2674-2679.

Cantorna, M.T., F. E. Nashold, and C.E. Hayes.  1995.  Vitamin A deficiency results in a priming environment conducive for Th1 cell development.  Eur. J. Immunol.  25:1673-1679.

Hayes, C.E., J.A. Carman, F.E. Nashold. and M. T. Cantorna.  1994.  Vitamin A:  A regulator of immune function.  In, Retinoids: From Basic Science to Clinical Applications, Eds., M. A. Livrea and G. Vidali, Birkhauser Publishing.  pp. 215-232.

Cantorna, M.T., F.E. Nashold, and C.E. Hayes.  1994.  In vitamin A deficiency multiple mechanisms establish a regulatory Th cell imbalance with excess Th1 and insufficient Th2 function.  J. Immunol.  152:1515-1522.

Cantorna, M.T., and E. Balish.  1991.  Acquired immunity to systemic candidiasis in immunodeficient mice.  J. Infect. Dis.  164:936-943.

Cantorna, M.T., and E. Balish.  1991.  Role of CD4+ lymphocytes in resistance to mucosal candidiasis.  Infect. Immun.  59:2447-2455.

Cantorna, M.T., and E. Balish.  1990.  Mucosal Immunity in Gnotobiotic Mice.  In, Microecology and Therapy, Eds.  P.J. Heidt, J.M. Vossen, and V.C. Rusch, Institut fur Mikrookologie, Herborn-Dill Germany.  Vol. 20.  pp. 335-338.

Cantorna, M. T., and E. Balish.  1990.  Mucosal and systemic candidiasis in congenitally immunodeficient mice.  Infect. Immun.  58:1093-1100.

Cantorna, M.T., and E. Balish.  1990.  Inability of human clinical strains of Helicobacter pylori to colonize the alimentary tract of  germfree rodents.  Can. J. Microbiol.  36:237-241.

Cantorna, M.T., D. Mook and E. Balish.  1990.  Resistance of congenitally immunodeficient gnotobiotic mice to vaginal candidiasis.  Infect. Immun.  58:1093-1100.