31st Summer Symposium in Molecular Biology

Xenobiotic Receptors: Physiological Regulators and Mediators of Toxicity

Date and Location

When (Date/Time)

July 22, 2012 11:00 AM to July 24, 2012 1:30 PM

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Hued Hepatocytes

Xenobiotic Receptors include members of the nuclear and soluble transcription factor superfamilies that serve as ‘xenosensors’ - chemical signal detectors and gene expression modulators that filter chemical  signals arising from a diverse array of environmental and endogenous substances. Upon activation, these receptors function to regulate numerous physiological processes ranging from the metabolism of steroids, pharmaceuticals and carcinogens, and in the control of critical lipid, cholesterol, energy and inflammatory pathways.

The 31st Penn State Summer Symposium in Molecular Biology will bring together preeminent scientists to focus on the most recent advances in Xenobiotic Receptor research that underlie their biological modes of action, and assess the impact of these processes on human health, chemical disposition and toxicity. Special emphasis will include focus on the receptors -  CAR/PXR (constitutive androstane and pregnane X receptors), the PPARs (peroxisome proliferator activated receptors), AhR (aryl hydrocarbon receptor) and highlight technological advances in comprehensive pathway analysis of these biological effectors.

The conference will be held at the upscale Nittany Lion Inn at Penn State University and is certain to be of broad interest to scientists engaged in all fields of basic research as well as those engaged as pharmaceutical and chemical industry scientists and government regulators.