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Current Publications

Humbert R, Adler DA, Diesteche CM, Hassett C, Omiecinski CJ, Furlong CE. The molecular basis of the human serum paraoxonase activity polymorphism. Nature Genetics 3: 73-76, 1993.

Hassett C, Aicher L, Sidhu JS, Omiecinski CJ. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Human Molecular Genetics. 3(3): 421-428. 1994.

2014

Elcombe CR, Peffer TC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Critical Reviews in Toxicology. 44(1):64-82. 2014.

2013

Shengzhong S, Omiecinski CJ. Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. Gene. 536: 135-144. 2013.

Chen F, Zamule SM, Coslo DM, Chen T, Omiecinski CJ. The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. Developmental Biology. 384: 155-165. 2013.

Takeda S, Yoshida K, Nishimura H, Harada M, Okajima S, Miyoshi H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. Δ9‑Tetrahydrocannabinol Disrupts Estrogen-Signaling through Up-Regulation of Estrogen Receptor β (ERβ)Chemical Research in Toxicology. 26(7): 1073-1079. 2013.

Nguyen HL, Yang X, Omiecinski CJ. Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5'-untranslated region. RNA. 19(6): 752-66. 2013.

2012

Laurenzana EM, Chen T, Kannuswamy M, Sell BE, Strom SC, Li Y, Omiecinski CJ. The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). Molecular Pharmacology. 82(5): 918-28, 2012.

2011

Omiecinski CJ, Coslo DM, Chen T, Laurenzana EM, Peffer RC. Multi-species analyses of direct activators of the constitutive androstane receptor. Toxicological Sciences. 123: 550-562, 2011

Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM. Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxcicities. Toxicological Sciences. 120(S1): S49-S75, 2011.

Zamule SM, Coslo DM, Chen F, Omiecinski CJ. Differentiation of Human Embryonic Stem Cells along a Hepatic Lineage. Chemico-Biological Interactions. 190: 62-82, 2011.

DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ. Selective Phthalate Activation of Naturally Occuring Human Constitutive androstane Receptor Splice Variants and the Pregnane X Receptor. Toxicological Sciences. 120: 381-391, 2011.

2010

Stagliano MC, Dekeyser JG, Omiecinski CJ, Jones AD. Bioassay-directed Fractionation for Discovery of Bioactive Neutral Lipids Guided by Relative Mass Defect Filtering and Multiplexed Colission-induced Dissociation. Rapid Communications in Mass Spectrometry. 24: 3578-3584, 2010.

Dinatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH. Kynurenic Acid is a Potent Endogenous Ah Receptor Ligand that Synergistically Induces Interleukin 6 in the Presence of Inflammatory Signaling. Toxicological Sciences. 115(1):89-97, 2010.

2009

Schroeder JC, Dinatale BC, Murray IA, Flaveny CA, Liu Q, Laurenzana EM, Lin JM, Strom SC, Omiecinski CJ, Amin S, Perdew GH. The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry 49: 393-400, 2009.

Moody DE, Fang, WB, Lin SN, Weyant DM, Strom SC, Omiecinski CJ. The effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes. Drug Metabolism Disposition 37: 2323-2329, 2009.

Yang X, Liang SH, Weyant DM, Lazarus P, Gallagher CJ, Omiecinski CJ. The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter. J Pharmacology & Experimental Therapeutics 330: 23-30, 2009.

Dekeyser JG, Stagliano MC, Auerbach SS, Prabu KS, Jones AD, Omiecinski CJ. Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant, CAR2. Molecular Pharmacology 75: 1005-1013, 2009.

2008

Goyak KMO, Johnson MC, Strom SC, Omiecinski CJ. Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures. Toxicology & Applied Pharmacology 231:216-224, 2008.

Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ 3rd, Krishnan K, Omiecinski CJ. Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Regulatory Toxicology & Pharmacology 51: 27-36, 2008.

Zamule SM, Strom SC, Omiecinski CJ. Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chemico-Biological Interactions 173:179-86, 2008.

2007

Patel RD, Hollingshead BD, Omiecinski CJ, Perdew GH. Ah receptor activation regulates constitutive androstane receptor (CAR) levels in murine and human liver. Hepatology 46: 209-218, 2007.

Page JL, Strom SC, Omiecinski CJ. Regulation of the human cathepsin E gene by the constitutive androstane receptor. Archives Biochemistry Biophysics 467: 132-138, 2007.

Page JL, Johnson MC, Olsavsky KM, Strom SC, Zarbl H, Omiecinski CJ, Gene Expression Profiling of Extracellular Matrix as an Effector of Human Hepatocyte Phenotype in Primary Cell Culture. Toxicological Sciences 97: 384–397 (2007).

Olsavsky KM, Page JL, Johnson,MC Zarbl H, Strom, SC Omiecinski CJ, Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicology and Applied Pharmacology 222: 42-56, 2007.

Stoner MA, Auerbach SS, Zamule SM, Strom SC, Omiecinski CJ , Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites. Nucleic Acids Research 35: 2177-90, 2007.

Auerbach SS,DeKeyser JG, Stoner MA, Omiecinski CJ, CAR2 Displays Unique Ligand Binding and RXR Heterodimerization Characteristics. Drug Metabolism and Disposition 35: 428-439, 2007.

Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H , Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers. Journal of Pharmacology and Experimental Therapeutics 320:72–80: 2007.

2005

Liang SH, Hassett C, Omiecinski CJ , Alternative Promoters Determine Tissue-Specific Expression Profiles of the Human Microsomal Epoxide Hydrolase Gene (EPHX1). Molecular Pharmacology 67: 220–230, 2005.

Auerbach SS, Stoner MA, Su S, Omiecinski CJ , Retinoid X Receptor-α Dependent Transactivation by a Naturally Occurring Structural Variant of Human Constitutive Androstane Receptor (NR1I3). Molecular Pharmacology 68: 1239–1253, 2005.

Sherif Z. Abdel-Rahman, Marinel M. Ammenheuser, Curtis J. Omiecinski, Jeffrey K. Wickliffe, Judah I. Rosenblatt, and Jonathan B. Ward, Jr. , Variability in Human Sensitivity to 1,3-Butadiene: Influence of Polymorphisms in the 5#-Flanking Region of the Microsomal Epoxide Hydrolase Gene (EPHX1) . Toxicological Sciences 85: 624–631, 2005.

Liang SH, Hassett C, Omiecinski CJ. Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1). Molecular Pharmacology 67: 1-11, 2005.

Abdel-Rahman SZ, Ammenheuser MM, Omiecinski CJ, Wickliffe JK, Rosenblatt JI, Ward JB Jr . Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). Toxicological Science 85: 624-631, 2005.

Auerbach SS, Su S, Stoner MA, Omiecinski CJ. RXR-dependent transactivation by a naturally occurring structural variant of human CAR (NR1I3). Molecular Pharmacology 68: 1239-1253, 2005.

2004

Hosagrahara VP; Rettie AE, Hassett C, Omiecinski CJ. Functional analysis of human microsomal epoxide hydrolase genetic variants. Chemico-Biological Interactions 150: 149-159, 2004.

Sidhu JS, Liu F, Omiecinski CJ. Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes. Experimental Cell Research 292: 252-264, 2004.

Yamamoto M, Mise M, Matsumoto S, Ito S, Gohyama N, Ishida S, Sagara Y, Omiecinski CJ, Oguri K, Yamada H. Comparison of Genomic and cDNA Sequences of Guinea Pig CYP2B18 and Rat CYP2B2: Absence of a Phenobarbital-responsive Enhancer Module in the Upstream Region of the CYP2B18 Gene. Journal of Biochemical and Molecular Toxicology 18: 124-130, 2004.

2003

Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C,Omiecinski CJ , Alternatively spliced isoforms of the human constitutive androstane receptor. Nucleic Acids Research 31: 3194-3207, 2003.

2001

Sidhu JS, Liu F, Boyle SM, Omiecinski CJ. PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes, Molecular Pharmacology 59: 1-9, 2001.

Farin FM, Janssen P, Quigley S, Abbott D, Hassett C, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Jr., Omiecinski CJ, Checkoway H. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease, Pharmacogenetics 11: 703-708, 2001.

2000

Krovat BC, Tracy JH, Omiecinski CJ. Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol Sci 55: 352-360, 2000.

Schilter B, Andersen MR, Acharya C, Omiecinski CJ. Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers, Journal of Pharmacology and Experimental Therapeutics 294: 916-922, 2000.

Beck NB, Sidhu JS, Omiecinski CJ . Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes, Gene Therapy 7: 1274-1283, 2000.

Sandberg M, Hassett C, Adman ET, Meijer J, Omiecinski CJ. Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms, Journal of Biological Chemistry 275: 28873-28881, 2000.

1999 and earlier

Ramsden R, Beck NA, Sommer KM, and Omiecinski, CJ. Phenobarbital responsiveness conferred by the rat CYP2B2 5'-flanking region in transgenic mice, Gene 228: 169-179, 1999.

Raaka S, Hassett C, Omiecinski CJ. Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms. Carcinogenesis 19: 387-393, 1998.

Sidhu JS, Omiecinski CJ. Protein synthesis inhibitors exhibit a non-specific effect on phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocytes. Journal of Biological Chemistry 273: 4769-4775, 1998.

Hassett C, Sidhu JS, Aicher L, Omiecinski CJ. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression of amino acid variants in vitro. Human Molecular Genetics 3: 421-428, 1994.