Dr. Roberta Pelanda is a member of the Department of Immunology and Microbiology at the University of Colorado School of Medicine.

When March 10, 2021, 11:00 AM - 12:00 PM

Where Zoom

Contact Margaret Weber

Contact Phone 814-865-7697

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Dr. Roberta Pelanda was born in Milano, Italy, where she received an M.S. in Biological Sciences and a Ph.D. in Cellular & Molecular Biology from the University of Milano. She trained as a postdoctoral fellow in immunology in the labs of Klaus Rajewsky first and Michael Reth later, in Germany. In 2001 she joined the Department of Immunology in Denver, Colorado where she is currently a full Professor with tenure in the Department of Immunology and Microbiology at the University of Colorado School of Medicine.

Dr. Pelanda studies the development and repertoire selection of B cells and her group has developed a variety of tools to investigate the molecular and biochemical pathways driving the selection of the primary repertoire of mouse and human B cells. Studies from her lab have established receptor editing as a main mechanism of central B cell tolerance and as a mechanism that can lead to the escape of autoreactive B cell clones from the bone marrow. Dr. Pelanda studies have been focused on exploring how B cells are selected out of the bone marrow, on identifying the molecular mechanisms that drive this selection for both non-autoreactive and autoreactive B cells, and to determine characteristics and mechanisms of B cells that participate in autoimmune responses. While most studies have been classically performed in mice, to bridge further studies in humans her group tests their discoveries in human immune system humanized mice, immunonodeficient mice that carry a human immune system. Dr. Pelanda's group has developed a humanized mouse model to investigate processes of tolerance and selection in human B cells from healthy and autoimmune prone' individuals. In addition, Dr. Pelanda has developed collaborations to use hu-mice to study a variety of immunological questions, including the response and interaction with EBV and the immune responses to colorectal carcinoma and other tumors. Dr. Pelanda co-directs a humanized mouse core facility that provides human immune system hu-mice to investigators at the University of Colorado.