Adam Glick, Ph.D.
- Professor of Molecular Toxicology and Carcinogenesis
- Associate Chair, Molecular Cellular and Integrative Biosciences Graduate Program
University Park, PA 16802
- Email abg11@psu.edu
- Office 814-865-7170
Websites
Graduate Programs
- Pathobiology
- Molecular Cellular Integrative Biosciences (MCIBS)
Research
Ras is one of the most frequently mutated oncogenes in human cancer. My laboratory focuses on basic mechanisms of Ras-driven cancer in epithelial cells using both in vitro primary cell culture and in vivo transgenic and knockout mouse models. Our current focus is on the role of IRE1α (ERN1) in the cellular response to oncogenic Ras and its role in both skin and lung cancer.
Publications
RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis
Journal of Dermatological Science, Mercurio, Laura, Bailey, Jacob, Glick, Adam Bleier, Dellambra, Elena, Scarponi, Claudia, Pallotta, Sabatino, Albanesi, Cristina, Madonna, Stefania, 2024
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Biomolecules, Zhu, Bokai, Zhu, Xiaoyang, Borland, Michael G., Ralph, Douglas H., Chiaro, Christopher R., Krausz, Kristopher W., Ntambi, James M., Glick, Adam B., Patterson, Andrew D., Perdew, Gary H., Gonzalez, Frank J., Peters, Jeffrey M., 2024
IRE1alpha Regulates ROS and Immune Responses after UV Irradiation
Redox Experimental Medicine, Glick, Adam, 2024
Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment
Advanced healthcare materials, Alden, Nick, Yeingst, Tyus, Pfeiffer, Hanna, Celik, Nazmiye, Arrizabalaga, Julien, Helton, Angelica, Liu, Yiming, Stairs, Douglas B., Glick, Adam B., Goyal, Neerav, Hayes, Daniel J., 2024
Biology of Stress Responses in Aging.
Aging Biology, Maragkakis, M, Malla, S, Hatzoglou, M, Trifunovic, A, Glick, Adam, Finkel, T, Longo, V, Kaushik, S, Muñoz-Cánoves, P, Lithgow, G, Naidoo, N, Booth, L, Payea, M, Herman, A, de Cabo, R, Wilson, D, Ferrucci, L, Gorospe, M, 2023
The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus
Developmental Biology, Chalmers, F, Mogre, S, Rimal, B, Son, J, Patterson, Andrew D., Stairs, Douglas B., Glick, Adam, 2022
TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes
Molecular Carcinogenesis, Mogre, Saie, Blazanin, Nicholas, Walsh, Hailey, Ibinson, Jack, Minnich, Chase, Andrew Hu, Chih Chi, Glick, Adam B., 2022
Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells
Langmuir, Alden, N, Arrizabalaga, J, Liu, Y, Amin, Shantu, Gowda, Krishne, Yao, S, Archetti, Marco, Glick, Adam, Hayes, Daniel J., 2022
The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis
Journal of Investigative Dermatology, Son, Jeongin, Mogre, Saie, Chalmers, Fiona E., Ibinson, Jack, Worrell, Stephen, Glick, Adam B., 2022
Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration
Developmental Biology, Chalmers, Fiona E., Dusold, Justyn E., Shaik, Javed A., Walsh, Hailey A., Glick, Adam B., 2022
Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice
Biomaterials, Liu, Yiming, Bailey, Jacob T., Abu-Laban, Mohammad, Li, Shue, Chen, Cong, Glick, Adam B., Hayes, Daniel J., 2020
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Cellular and Molecular Bioengineering, Aronson, M, Aronson^, Matthew, Dahl, Erika, Halle, J, Halle^, Jacob, Simonson^, Andrew, Simonson, A, Gogal, Rose, Glick, Adam B., Aird, K, Medina, Scott H., 2020
Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks
ACS Nano, Sloand, Janna, Sloand^, Janna, Cook, Eric, Nguyen, Theodore, Zinck, Scott A., Zimudzi, Tawanda, Cook, Erik C., Zinck, Scott, Showalter, S, Zimudzi, Tawanda J., Schowalter, Scott, Showalter, Scott A., Simon, Julianna, Medina, S, Glick, Adam B., Simon, Julianna, Medina*, Scott, 2020
The multiple roles of the unfolded protein response regulator IRE1α in cancer
Molecular Carcinogenesis, Chalmers, Fiona, Mogre, Saie, Son, Jeongin, Blazanin, Nicholas, Glick, Adam B., 2019
Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin
Toxicological Sciences, Smith, K, Boyer, J, Muku, G, Murray, I, Gowda, Krishne, Desai, D, Amin, S, Glick, A, Perdew, Gary, 2017
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Proceedings of the National Academy of Sciences of the United States of America, Blazanin, Nicholas, Son, Jeongin, Craig-Lucas, Alayna B., John, Christian L., Breech, Kyle J., Podolsky, Michael A., Glick, Adam B., 2017
Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Journal of Embryology and Experimental Morphology, Wu, Hsing Jung, Oh, Ji Won, Spandau, Dan F., Tholpady, Sunil, Diaz, Jesus, Schroeder, Laura J., Offutt, Carlos D., Glick, Adam B., Plikus, Maksim V., Koyama, Sachiko, Foley, John, 2017
Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-RasG12V-induced squamous tumors
Cancer immunology research, Podolsky, Michael A., Bailey, Jacob T., Gunderson, Andrew J., Oakes, Carrie J., Breech, Kyle, Glick, Adam B., 2017
Participation of Fos and Jun in multistage carcinogenesis, Glick, Adam, Yuspa, Stuart H., 2017
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Journal of Investigative Dermatology, Van Den Bogaard, Ellen H., Podolsky, Michael A., Smits, Jos P., Cui, Xiao, John, Christian, Gowda, Krishne, Desai, Dhimant, Amin, Shantu G., Schalkwijk, Joost, Perdew, Gary H., Glick, Adam B., 2015
Epithelial Skin Cancers, Glick, Adam, Yuspa, S., 2015
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling
Oncogene, Zhu, B., Ferry, C. H., Blazanin, N., Bility, M. T., Khozoie, C., Kang, B. H., Glick, A. B., Gonzalez, F. J., Peters, J. M., 2014
Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells
Carcinogenesis, Ravindran, Anand, Mohammed, Javed, Gunderson, Andrew J., Cui, Xiao, Glick, Adam B., 2014
Epithelial Skin Cancer, Glick, Adam B., Yuspa, Stuart H., 2014
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Journal of Biological Chemistry, Zhu, Bokai, Ferry, Christina H., Markell, Lauren K., Blazanin, Nicholas, Glick, Adam B., Gonzalez, Frank J., Peters, Jeffrey M., 2014
