Adam Glick, PhD

Adam Glick, PhD

  • Professor of Molecular Toxicology and Carcinogenesis
  • Associate Chair, Molecular Cellular and Integrative Biosciences Graduate Program
306C Life Sciences Bldg
University Park, PA 16802

Graduate Programs

Research

Ras is one of the most frequently mutated oncogenes in human cancer. My laboratory focuses on basic mechanisms of Ras-driven cancer in epithelial cells using both in vitro primary cell culture and in vivo transgenic and knockout mouse models. Our current focus is on the role of IRE1α (ERN1) in the cellular response to oncogenic Ras and its role in both skin and lung cancer.

Publications

Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice.
Biomaterials, Liu, Y, Bailey, J, Abu-Laban, M, Li, S, Chen, C, Glick, Adam, Hayes, D, 2020

Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks.
ACS nano, Sloand, J, Nguyen, Toan, Zinck, S, Cook, E, Zimudzi, T, Showalter, Scott, Glick, Adam, Simon, Julianna, Medina, Scott, 2020

Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Cellular and Molecular Bioengineering, Aronson, Matthew, Dahl, Erika, Halle, Jacob, Simonson, Andrew, Gogal, Rose, Glick, Adam, Aird, Katherine, Medina, Scott, 2020

The multiple roles of the unfolded protein response regulator IRE1α in cancer
Molecular Carcinogenesis, Chalmers, Fiona, Mogre, Saie, Son, Jeongin, Blazanin, Nicholas, Glick, Adam Bleier, 2019

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Proceedings of the National Academy of Sciences of the United States of America, Blazanin, Nicholas, Son, Jeongin, Craig-Lucas, Alayna B., John, Christian L., Breech, Kyle J., Podolsky, Michael A., Glick, Adam B., 2017

Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Development (Cambridge), Wu, Hsing Jung, Oh, Ji Won, Spandau, Dan F., Tholpady, Sunil, Diaz, Jesus, Schroeder, Laura J., Offutt, Carlos D., Glick, Adam B., Plikus, Maksim V., Koyama, Sachiko, Foley, John, 2017

Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-RasG12V-induced squamous tumors
Cancer Immunology Research, Podolsky, Michael A., Bailey, Jacob T., Gunderson, Andrew J., Oakes, Carrie J., Breech, Kyle, Glick, Adam B., 2017

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Journal of Investigative Dermatology, Van Den Bogaard, Ellen H., Podolsky, Michael A., Smits, Jos P., Cui, Xiao, John, Christian, Gowda, Krishne, Desai, Dhimant, Amin, Shantu G., Schalkwijk, Joost, Perdew, Gary H., Glick, Adam B., 2015

Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells
Carcinogenesis, Ravindran, Anand, Mohammed, Javed, Gunderson, Andrew J., Cui, Xiao, Glick, Adam B., 2014

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Journal of Biological Chemistry, Zhu, Bokai, Ferry, Christina H., Markell, Lauren K., Blazanin, Nicholas, Glick, Adam B., Gonzalez, Frank J., Peters, Jeffrey M., 2014

The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes.
Cytokine, Hogan, K, Ravindran, Arunachalam, Podolsky, M, Glick, Adam, 2013

Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy
PloS one, Narola, Jigna, Pandey, Sachchida Nand, Glick, Adam, Chen, Yi Wen, 2013

Impairment of regulatory T-cell function in autoimmune thyroid disease.
Thyroid : official journal of the American Thyroid Association, Glick, Adam, Wodzinski, A, Fu, P, Levine, A, Wald, D, 2013

CD8+ T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ
Journal of Investigative Dermatology, Gunderson, Andrew J., Mohammed, Javed, Horvath, Frank J., Podolsky, Michael A., Anderson, Cherie R., Glick, Adam B., 2013

TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity
Journal of Investigative Dermatology, Mohammed, Javed, Gunderson, Andrew J., Khong, Hong Hanh, Koubek, Richard D., Udey, Mark C., Glick, Adam B., 2013

Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth
Cancer Research, Plichta, Kristin A., Mathers, Jessica L., Gestl, Shelley A., Glick, Adam Bleier, Gunther, Edward, 2012

S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion
Carcinogenesis, Shi, Chenxu, Cooper, Timothy, Mccloskey, Diane E., Glick, Adam Bleier, Shantz, Lisa, Feith, David J., 2012

A new xenotransplantation model reveals tumor initiating cells in cutaneous
SCC. J. Invest. Dermatol., Glick, Adam, 2012

The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models.
Journal of skin cancer, Glick, Adam, 2012

Pharmacologic inhibition of ALK5 causes selective induction of terminal differentiation in mouse keratinocytes expressing oncogenic HRAS
Molecular Cancer Research, Mordasky Markell, Lauren, Masiuk, Katelyn E., Blazanin, Nicholas, Glick, Adam B., 2011

Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progression
Carcinogenesis, Markell, Lauren Mordasky, Pérez-Lorenzo, Rolando, Masiuk, Katelyn E., Kennett, Mary J., Glick, Adam B., 2010

TGFΒ1-induced inflammation in premalignant epidermal squamous lesions requires IL-17
Journal of Investigative Dermatology, Mohammed, Javed, Ryscavage, Andrew, Perez-Lorenzo, Rolando, Gunderson, Andrew J., Blazanin, Nicholas, Glick, Adam Bleier, 2010

Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
American Journal of Pathology, Koesters, Robert, Kaissling, Brigitte, LeHir, Michel, Picard, Nicolas, Theilig, Franziska, Gebhardt, Rolf, Glick, Adam B., Hähnel, Brunhilde, Hosser, Hiltraud, Gröne, Hermann Josef, Kriz, Wilhelm, 2010

Transforming growth factor β1 enhances tumor promotion in mouse skin carcinogenesis
Carcinogenesis, Pérez-Lorenzo, Rolando, Markell, Lauren Mordasky, Hogan, Kelly A., Yuspa, Stuart H., Glick, Adam Bleier, 2010