Andrew D. Patterson, PhD

Andrew D. Patterson, PhD

  • Tombros Early Career Professor
  • Professor of Molecular Toxicology
  • Professor of Biochemistry & Molecular Biology
322 Life Sciences Bldg
University Park, PA 16802

Areas of Expertise

  • Metabolomics
  • Microbiome
  • Drug Metabolism
  • Metabolism
  • Environmental Contaminants

Education

  • Research Fellow, National Cancer Institute (NCI), 2006-2011
  • Pharmacology Research Associate in Training Fellow, National Institute of General Medical Sciences (NIGMS), 2006-2009
  • PhD, Genetics, Graduate Partnerships Program, NCI and George Washington University, 2006
  • BS, Microbiology, Penn State University, 1999

Dr. Patterson is Professor of Molecular Toxicology at the Pennsylvania State University, University Park, PA and is the Scientific Director of Metabolomics. He and his students, postdocs, and collaborators focus on understanding the host-metabolite-microbiota communication network—specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host nuclear/soluble receptors (e.g., farnesoid X receptor, aryl hydrocarbon receptor). The lab employs a variety of tools, including NMR- and mass spectrometry-based metabolomics, genomics, and conventional and gnotobiotic transgenic mice, to facilitate its study of these pathways and understand their impact on human health and disease. 

Publications

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis
Toxicology, Liu, Qing, Zhang, Limin, Allman, Erik L., Hubbard, Troy D., Murray, Iain A., Hao, Fuhua, Tian, Yuan, Gui, Wei, Nichols, Robert G., Smith, Philip B., Anitha, Mallappa, Perdew, Gary H., Patterson, Andrew D., 2021

The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis
Arthritis and Rheumatology, Artacho, Alejandro, Isaac, Sandrine, Nayak, Renuka, Flor-Duro, Alejandra, Alexander, Margaret, Koo, Imhoi, Manasson, Julia, Smith, Philip B., Rosenthal, Pamela, Homsi, Yamen, Gulko, Percio, Pons, Javier, Puchades-Carrasco, Leonor, Izmirly, Peter, Patterson, Andrew, Abramson, Steven B., Pineda-Lucena, Antonio, Turnbaugh, Peter J., Ubeda, Carles, Scher, Jose U., 2021

Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation
Cell Host and Microbe, Nayak, Renuka R., Alexander, Margaret, Deshpande, Ishani, Stapleton-Gray, Kye, Rimal, Bipin, Patterson, Andrew D., Ubeda, Carles, Scher, Jose U., Turnbaugh, Peter J., 2021

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice
PLoS One, Winston, Jenessa A., Rivera, Alissa, Cai, Jingwei, Patterson, Andrew D., Theriot, Casey M., 2021

Comparison of the effects of short-term feeding of sodium acetate and sodium bicarbonate on milk fat production
Journal of Dairy Science, Matamoros, C., Cai, J., Patterson, A. D., Harvatine, K. J., 2021

Selenium-dependent metabolic reprogramming during inflammation and resolution
Journal of Biological Chemistry, Korwar, Arvind M., Hossain, Ayaan, Lee, Tai Jung, Shay, Ashley E., Basrur, Venkatesha, Conlon, Kevin, Smith, Philip B., Carlson, Bradley A., Salis, Howard M., Patterson, Andrew D., Prabhu, K. Sandeep, 2021

Impaired intestinal akkermansia muciniphila and aryl hydrocarbon receptor ligands contribute to nonalcoholic fatty liver disease in mice
mSystems, Shi, Zunji, Lei, Hehua, Chen, Gui, Yuan, Peihong, Cao, Zheng, Ser, Hooi Leng, Zhu, Xuehang, Wu, Fang, Liu, Caixiang, Dong, Manyuan, Song, Yuchen, Guo, Yangyang, Chen, Chuan, Hu, Kexin, Zhu, Yifan, Zeng, Xin An, Zhou, Jinlin, Lu, Yujing, Patterson, Andrew D., Zhang, Limin, 2021

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis
Clinical Gastroenterology and Hepatology, Hughes, Alexa, Dahmus, Jessica, Rivas, Gloriany, Hummer, Breianna, Chen See, Jeremy R., Wright, Justin R., Lamendella, Regina, Schmitz, Kathryn H., Sciamanna, Christopher, Ruffin, Mack, Patterson, Andrew D., Loomba, Rohit, Stine, Jonathan G., 2021

Quantitative analysis of bile acid with UHPLC-MS/MS, Tian, Yuan, Cai, Jingwei, Allman, Erik L., Smith, Philip B., Patterson, Andrew D., 2021

Sample preparation and data analysis for NMR-based metabolomics, Mal, Tapas K., Tian, Yuan, Patterson, Andrew D., 2021

A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance
Proceedings of the National Academy of Sciences of the United States of America, Man, Kevin, Bowman, Christopher, Braverman, Kristina N., Escalante, Veronica, Tian, Yuan, Bisanz, Jordan E., Ganeshan, Kirthana, Wang, Biao, Patterson, Andrew, Bayrer, James R., Turnbaugh, Peter J., Chawla, Ajay, 2020

How gut microbiome interactions affect nutritional traits of Drosophila melanogaster
Journal of Experimental Biology, McMullen, John G., Peters-Schulze, Grace, Cai, Jingwei, Patterson, Andrew D., Douglas, Angela E., 2020

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, J, Wright, J, Lamendella, R, Schmitz, K, Sciamanna, C, Ruffin, M, Patterson, Andrew, Loomba, R, Stine, J, 2020

Metabolic profiling reveals aggravated non-alcoholic steatohepatitis in high-fat high-cholesterol diet-fed apolipoprotein e-deficient mice lacking ron receptor signaling
Metabolites, Allen, Joselyn N., Dey, Adwitia, Cai, Jingwei, Zhang, Jingtao, Tian, Yuan, Kennett, Mary, Ma, Yanling, Liang, T. Jake, Patterson, Andrew D., Hankey-Giblin, Pamela A., 2020

Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice
Physiological Genomics, Singh, Vishal, Galla, Sarah, Golonka, Rachel M., Patterson, Andrew D., Chassaing, Benoit, Joe, Bina, Vijay-Kumar, Matam, 2020

Mdm2-dependent rewiring of metabolomic and lipidomic profiles in dedifferentiated liposarcoma models
Cancers, Patt, Andrew, Demoret, Bryce, Stets, Colin, Bill, Kate Lynn, Smith, Philip, Vijay, Anitha, Patterson, Andrew, Hays, John, Hoang, Mindy, Chen, James L., Mathé, Ewy A., 2020

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota
Gut Microbes, Singh, Vishal, Yeoh, Beng San, Abokor, Ahmed A., Golonka, Rachel M., Tian, Yuan, Patterson, Andrew D., Joe, Bina, Heikenwalder, Mathias, Vijay-Kumar, Matam, 2020

The microbiome modulating activity of bile acids
Gut Microbes, Tian, Yuan, Gui, Wei, Koo, Imhoi, Smith, Philip B., Allman, Erik L., Nichols, Robert G., Rimal, Bipin, Cai, Jingwei, Liu, Qing, Patterson, Andrew D., 2020

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells
Cell, Ang, Qi Yan, Alexander, Margaret, Newman, John C., Tian, Yuan, Cai, Jingwei, Upadhyay, Vaibhav, Turnbaugh, Jessie A., Verdin, Eric, Hall, Kevin D., Leibel, Rudolph L., Ravussin, Eric, Rosenbaum, Michael, Patterson, Andrew D., Turnbaugh, Peter J., 2020

Bacterial colonization reprograms the neonatal gut metabolome
Nature Microbiology, Bittinger, Kyle, Zhao, Chunyu, Li, Yun, Ford, Eileen, Friedman, Elliot S., Ni, Josephine, Kulkarni, Chiraag V., Cai, Jingwei, Tian, Yuan, Liu, Qing, Patterson, Andrew D., Sarkar, Debolina, Chan, Siu H.J., Maranas, Costas, Saha-Shah, Anumita, Lund, Peder, Garcia, Benjamin A., Mattei, Lisa M., Gerber, Jeffrey S., Elovitz, Michal A., Kelly, Andrea, DeRusso, Patricia, Kim, Dorothy, Hofstaedter, Casey E., Goulian, Mark, Li, Hongzhe, Bushman, Frederic D., Zemel, Babette S., Wu, Gary D., 2020

Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH
Contemporary Clinical Trials Communications, Stine, Jonathan G., Schreibman, Ian, Navabi, Seyedehsan, Kang, Mitchell, Dahmus, Jessica, Soriano, Christopher, Rivas, Gloriany, Hummer, Breianna, Beyer, Megan, Tressler, Heather, Kimball, Scot R., Patterson, Andrew D., Schmitz, Kathryn, Sciamanna, Christopher, 2020

Ursodeoxycholic acid (udca) mitigates the host inflammatory response during clostridioides difficile infection by altering gut bile acids
Infection and Immunity, Winston, Jenessa A., Rivera, Alissa J., Cai, Jingwei, Thanissery, Rajani, Montgomery, Stephanie A., Patterson, Andrew D., Theriot, Casey M., 2020

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice
Toxicology, Zhang, Limin, Rimal, Bipin, Nichols, Robert G., Tian, Yuan, Smith, Philip B., Hatzakis, Emmanuel, Chang, Shu Ching, Butenhoff, John L., Peters, Jeffrey M., Patterson, Andrew D., 2020

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis
Cell Metabolism, Das, Nupur K., Schwartz, Andrew J., Barthel, Gabrielle, Inohara, Naohiro, Liu, Qing, Sankar, Amanda, Hill, David R., Ma, Xiaoya, Lamberg, Olivia, Schnizlein, Matthew K., Arqués, Juan L., Spence, Jason R., Nunez, Gabriel, Patterson, Andrew D., Sun, Duxin, Young, Vincent B., Shah, Yatrik M., 2020

The gut microbiome
Acta Pharmaceutica Sinica B, Collins, Stephanie L., Patterson, Andrew D., 2020

Metabolic impact of persistent organic pollutants on gut microbiota
Gut Microbes, Tian, Yuan, Gui, Wei, Rimal, Bipin, Koo, Imhoi, Smith, Philip B., Nichols, Robert G., Cai, Jingwei, Liu, Qing, Patterson, Andrew D., 2020

Impact of facultative bacteria on the metabolic function of an obligate insect-bacterial symbiosis
mBio, Blow, Frances, Ankrah, Nana Y.D., Clark, Noah, Koo, Imhoi, Allman, Erik L., Liu, Qing, Anitha, Mallappa, Patterson, Andrew D., Douglas, Angela E., 2020

Roux-en-Y Gastric Bypass Surgery Has Early Differential Effects on Bile Acids and the Levels of Complement Component 3 and Acylation-Stimulating Protein
Obesity Surgery, Noel, Olivier F., Chu, Xin, Patterson, Andrew D., Edwards, Michael A., Still, Christopher D., Gerhard, Glenn S., 2020

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran
Metabolites, Nichols, Robert G., Zhang, Jingtao, Cai, Jingwei, Murray, Iain A., Koo, Imhoi, Smith, Philip B., Perdew, Gary H., Patterson, Andrew D., 2020

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.
Metabolites, Nichols, Renea, Zhang, Jian, Cai, Jingjing, Murray, Iain, Koo, I, Smith, Philip, Perdew, Gary, Patterson, Andrew, 2019

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2
Scientific Reports, Bao, Lei, Festa, Fernanda, Freet, Christopher S., Lee, John P., Hirschler-Laszkiewicz, Iwona M., Chen, Shu jen, Keefer, Kerry A., Wang, Hong Gang, Patterson, Andrew D., Cheung, Joseph Y., Miller, Barbara A., 2019

Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis.
NPJ precision oncology, Peters, J, Walter, V, Patterson, Andrew, Gonzalez, F, 2019

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation.
Gut, Singh, Vishal, Yeoh, B, Walker, Ronald, Xiao, X, Saha, Piu, Golonka, R, Cai, J, Bretin ACA, , Cheng, X, Liu, Q, Flythe, M, Chassaing, B, Shearer, Gregory, Patterson, Andrew, Gewirtz, A, Vijay-Kumar, M, 2019

Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host
International Journal of Molecular Sciences, Zheng, Shanshan, Loreto, Raquel, Smith, Philip, Patterson, Andrew, Hughes, David, Wang, Liande, 2019

Publisher Correction
Nature Medicine, Qi, Xinyu, Yun, Chuyu, Sun, Lulu, Xia, Jialin, Wu, Qing, Wang, Ying, Wang, Lina, Zhang, Yangming, Liang, Xianyi, Wang, Liying, Gonzalez, Frank J., Patterson, Andrew D., Liu, Huiying, Mu, Liangshan, Zhou, Zehong, Zhao, Yue, Li, Rong, Liu, Ping, Zhong, Chao, Pang, Yanli, Jiang, Changtao, Qiao, Jie, 2019

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass
Cell Metabolism, Chagwedera, D. Nyasha, Ang, Qi Yan, Bisanz, Jordan E., Leong, Yew Ann, Ganeshan, Kirthana, Cai, Jingwei, Patterson, Andrew D., Turnbaugh, Peter J., Chawla, Ajay, 2019

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche
Blood advances, Hao, Siyang, Xiang, Jie, Wu, Dai Chen, Fraser, James W., Ruan, Baiye, Cai, Jingwei, Patterson, Andrew D., Lai, Zhi Chun, Paulson, Robert F., 2019

A review of analytical platforms for accurate bile acid measurement
Fresenius Zeitschrift fur Analytische Chemie, Dutta, Mainak, Cai, Jingwei, Gui, Wei, Patterson, Andrew D., 2019

Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry
Fresenius Zeitschrift fur Analytische Chemie, Zheng, Xueyun, Smith, Francesca B., Aly, Noor A., Cai, Jingwei, Smith, Richard D., Patterson, Andrew D., Baker, Erin S., 2019

A Quantitative HILIC-MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
Metabolites, Liu, Q, Cai, Jingjing, Nichols, Renea, Tian, Y, Zhang, Jian, Smith, Philip, Wang, Yanling, Yan, C, Patterson, Andrew, 2019

Interplay Between the Host, the Human Microbiome, and Drug Metabolism
Human Genomics, Nichols, Robert G., Peters, Jeffrey M., Patterson, Andrew D., 2019

Isolation and identification of aryl hydrocarbon receptor modulators in white button mushrooms (Agaricus bisporus)
Journal of Agricultural and Food Chemistry, Tian, Yuan, Gui, Wei, Smith, Philip B., Koo, Imhoi, Murray, Iain A., Cantorna, Margherita T., Perdew, Gary H., Patterson, Andrew D., 2019

Microbiota metabolism promotes synthesis of the human Ah receptor agonist 2,8-dihydroxyquinoline.
Journal of Proteome Research, Hubbard, Troy D., Liu, Qing, Murray, Iain A., Dong, Fangcong, Miller, Charles, Smith, Philip B., Gowda, Krishne, Lin, Jyh Ming, Amin, Shantu, Patterson, Andrew D., Perdew, Gary H., 2019

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation
Drug Metabolism and Disposition, Tian, Yuan, Cai, Jingwei, Gui, Wei, Nichols, Robert G., Koo, Imhoi, Zhang, Jingtao, Anitha, Mallappa, Patterson, Andrew David, 2019

Metabolomic approaches reveal the role of CAR in energy metabolism
Journal of Proteome Research, Chen, Fengming, Coslo, Denise M., Chen, Tao, Zhang, Limin, Tian, Yuan, Smith, Philip B., Patterson, Andrew D., Omiecinski, Curtis J., 2019

Vitamin D regulates the microbiota to control the numbers of RORγt/FoxP3+ regulatory T cells in the colon
Frontiers in Immunology, Cantorna, Margherita T., Lin, Yang Ding, Arora, Juhi, Bora, Stephanie, Tian, Yuan, Nichols, Robert G., Patterson, Andrew D., 2019

Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells
Frontiers in Immunology, Snyder, Lindsay M., McDaniel, Kaitlin L., Tian, Yuan, Wei, Cheng Hsin, Kennett, Mary J., Patterson, Andrew David, Ross, A. Catharine, Cantorna, Margherita Teresa-Anna, 2019

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
Nature Medicine, Sun, Lulu, Xie, Cen, Wang, Guang, Wu, Yue, Wu, Qing, Wang, Xuemei, Liu, Jia, Deng, Yangyang, Xia, Jialin, Chen, Bo, Zhang, Songyang, Yun, Chuyu, Lian, Guan, Zhang, Xiujuan, Zhang, Heng, Bisson, William H., Shi, Jingmin, Gao, Xiaoxia, Ge, Pupu, Liu, Cuihua, Krausz, Kristopher W., Nichols, Robert G., Cai, Jingwei, Rimal, Bipin, Patterson, Andrew D., Wang, Xian, Gonzalez, Frank J., Jiang, Changtao, 2018

Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity
mSystems, Cai, Jingwei, Nichols, Robert G., Koo, Imhoi, Kalikow, Zachary A., Zhang, Limin, Tian, Yuan, Zhang, Jingtao, Smith, Philip B., Patterson, Andrew David, 2018

Structural and Functional Analysis of the Gut Microbiome for Toxicologists
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.], Nichols, Robert G., Cai, Jingwei, Murray, Iain Alexander, Koo, Imhoi, Smith, Philip B., Perdew, Gary H., Patterson, Andrew David, 2018

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism.
Journal of proteome research, 2018

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer
Cell, Singh, Vishal, Yeoh, Beng San, Chassaing, Benoit, Xiao, Xia, Saha, Piu, Aguilera Olvera, Rodrigo, Lapek, John D., Zhang, Limin, Wang, Wei-bei, Hao, Sijie, Flythe, Michael D., Gonzalez, David J., Cani, Patrice D., Conejo-Garcia, Jose R., Xiong, Na, Kennett, Mary J., Joe, Bina, Patterson, Andrew David, Gewirtz, Andrew T., Vijay-Kumar, Matam, 2018

Lipid metabolism and lipophagy in cancer
Biochemical and Biophysical Research Communications, Maan, Meenu, Peters, Jeffrey Maurice, Dutta, Mainak, Patterson, Andrew David, 2018

Molecular Regulation of Carcinogenesis
Toxicological Sciences, Patterson, Andrew D., Gonzalez, Frank J., Perdew, Gary H., Peters, Jeffrey M., 2018

The association of lipophilic phospholipids with native bovine casein micelles in skim milk
Journal of Dairy Science, Cheema, M., Smith, Philip B., Patterson, A. D., Hristov, Alexander Nikolov, Harte, Federico Miguel, 2018

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism
Hepatology, Pathak, Preeti, Xie, Cen, Nichols, Robert G., Ferrell, Jessica M., Boehme, Shannon, Krausz, Kristopher W., Patterson, Andrew David, Gonzalez, Frank J., Chiang, John Y.L., 2018

Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model
Journal of Proteome Research, Allen, Joselyn, Zhang, Jingtao, Quickel, Michael D., Kennett, Mary J., Patterson, Andrew David, Giblin, Pamela Hankey, 2018

Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice
Journal of Functional Foods, Tian, Yuan, Nichols, Robert G., Roy, Pratiti, Gui, Wei, Smith, Philip B., Zhang, Jingtao, Lin, Yangding, Weaver, Veronika, Cai, Jingwei, Patterson, Andrew David, Cantorna, Margherita Teresa-Anna, 2018

Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics
Nutrition Reports International, Bora, Stephanie A., Kennett, Mary J., Smith, Philip B., Patterson, Andrew David, Cantorna, Margherita Teresa-Anna, 2018

Metabolomics reveals aryl hydrocarbon receptor activation induces liver and mammary gland metabolic dysfunction in lactating mice
Journal of Proteome Research, Belton, Kerry R., Tian, Yuan, Zhang, Limin, Anitha, Mallappa, Smith, Philip B., Perdew, Gary H., Patterson, Andrew David, 2018

Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis
Nutrition Reports International, Tian, Yuan, Nichols, Robert G., Cai, Jingwei, Patterson, Andrew David, Cantorna, Margherita Teresa-Anna, 2018

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Frontiers in Immunology, Dey, Adwitia, Allen, Joselyn N., Fraser, James W., Snyder, Lindsay M., Tian, Yuan, Zhang, Limin, Paulson, Robert F., Patterson, Andrew, Cantorna, Margherita T., Hankey-Giblin, Pamela A., 2018

The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23
Frontiers in Immunology, Bora, Stephanie A., Kennett, Mary J., Smith, Philip B., Patterson, Andrew D., Cantorna, Margherita T., 2018

Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells
Frontiers in immunology, Snyder, Lindsay, McDaniel, Kaitlin, Tian, Yuan, Wei, Cheng-Hsin, Kennett, M, Patterson, Andrew, Ross, A Catharine, None, Cantorna, M, 2018

Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1
Hypertension, Waghulde, Harshal, Cheng, Xi, Galla, Sarah, Mell, Blair, Cai, Jingwei, Pruett-Miller, Shondra M., Vazquez, Guillermo, Patterson, Andrew, Kumar, Matam Vijay, Joe, Bina, 2018

Erratum
Cell Metabolism, Li, Guolin, Xie, Cen, Lu, Siyu, Nichols, Robert G., Tian, Yuan, Li, Licen, Patel, Daxeshkumar, Ma, Yinyan, Brocker, Chad N., Yan, Tingting, Krausz, Kristopher W., Xiang, Rong, Gavrilova, Oksana, Patterson, Andrew D., Gonzalez, Frank J., 2017

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis
Nature Medicine, Xie, Cen, Yagai, Tomoki, Luo, Yuhong, Liang, Xianyi, Chen, Tao, Wang, Qiong, Sun, Dongxue, Zhao, Jie, Ramakrishnan, Sadeesh K., Sun, Lulu, Jiang, Chunmei, Xue, Xiang, Tian, Yuan, Krausz, Kristopher W., Patterson, Andrew David, Shah, Yatrik M., Wu, Yue, Jiang, Changtao, Gonzalez, Frank J., 2017

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
Cell Metabolism, Li, Guolin, Xie, Cen, Lu, Siyu, Nichols, Robert G., Tian, Yuan, Li, Licen, Patel, Daxeshkumar, Ma, Yinyan, Brocker, Chad N., Yan, Tingting, Krausz, Kristopher W., Xiang, Rong, Gavrilova, Oksana, Patterson, Andrew David, Gonzalez, Frank J., 2017

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner
Journal of Functional Foods, Hubbard, Troy D., Murray, Iain Alexander, Nichols, Robert G., Cassel, Kaitlyn, Podolsky, Michael, Kuzu, Guray, Tian, Yuan, Smith, Philip B., Kennett, Mary J., Patterson, Andrew David, Perdew, Gary H., 2017

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA
PLoS One, DiMarzio, Michael, Rusconi, Brigida, Yennawar, Neela, Eppinger, Mark, Patterson, Andrew David, Dudley, Edward G., 2017

Orthogonal comparison of GC-MS and 1H NMR spectroscopy for short chain fatty acid quantitation
Analytical Chemistry, Cai, Jingwei, Zhang, Jingtao, Tian, Yuan, Zhang, Limin, Hatzakis, Emmanuel, Krausz, Kristopher W., Smith, Philip B., Gonzalez, Frank J., Patterson, Andrew David, 2017

An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice
Diabetes, Xie, Cen, Jiang, Changtao, Shi, Jingmin, Gao, Xiaoxia, Sun, Dongxue, Sun, Lulu, Wang, Ting, Takahashi, Shogo, Anitha, Mallappa, Krausz, Kristopher W., Patterson, Andrew David, Gonzalez, Frank J., 2017

Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease
Digestive Diseases, Gonzalez, Frank J., Jiang, Changtao, Xie, Cen, Patterson, Andrew D., 2017

Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice
Nutrition Reports International, Xiao, Xia, Yeoh, Beng San, Saha, Piu, Tian, Yuan, Singh, Vishal, Patterson, Andrew D., Vijay-Kumar, Matam, 2017

The aryl hydrocarbon receptor as a moderator of host-microbiota communication
Current Opinion in Toxicology, Zhang, Limin, Nichols, Robert G., Patterson, Andrew D., 2017

Lipid emulsion added to a liquid high-carbohydrate diet and voluntary running exercise reduce lipogenesis and ameliorate early-stage hepatic steatosis in mice
Journal of Nutrition, Huang, Kuan Hsun, Hao, Lei, Smith, Philip B., Rogers, Connie J., Patterson, Andrew D., Ross, A. Catharine, 2017

Omics Approaches to Probe Microbiota and Drug Metabolism Interactions
Chemical Research in Toxicology, Nichols, Robert G., Hume, Nicole E., Smith, Philip B., Peters, Jeffrey M., Patterson, Andrew D., 2016

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
Gastroenterology, Gonzalez, Frank J., Jiang, Changtao, Patterson, Andrew D., 2016

NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research
Current Pharmacology Reports, Zhang, Limin, Hatzakis, Emmanuel, Patterson, Andrew D., 2016

Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice
Scientific Reports, Murray, Iain A., Nichols, Robert G., Zhang, Limin, Patterson, Andrew D., Perdew, Gary H., 2016

Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism
mSystems, Zhang, Limin, Xie, Cen, Nichols, Robert G., Chan, Siu H.J., Jiang, Changtao, Hao, Ruixin, Smith, Philip B., Cai, Jingwei, Simons, Margaret N., Hatzakis, Emmanuel, Maranas, Costas D., Gonzalez, Frank J., Patterson, Andrew D., 2016

Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice
Toxicological Sciences, Zhang, Limin, Krishnan, Prasad, Ehresman, David J., Smith, Philip B., Dutta, Mainak, Bagley, Bradford D., Chang, Shu Ching, Butenhoff, John L., Patterson, Andrew D., Peters, Jeffrey M., 2016

Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis
Journal of Proteome Research, Dutta, Mainak, Anitha, Mallappa, Smith, Philip B., Chiaro, Christopher R., Maan, Meenu, Chaudhury, Koel, Patterson, Andrew David, 2016

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Journal of Immunology, Yu, Shan, Allen, Joselyn N., Dey, Adwitia, Zhang, Limin, Balandaram, Gayathri, Kennett, Mary J., Xia, Mingcan, Xiong, Na, Peters, Jeffrey Maurice, Patterson, Andrew David, Giblin, Pamela Hankey, 2016

Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer
Cancer Research, Cook, John A., Chandramouli, Gadisetti V.R., Anver, Miriam R., Sowers, Anastasia L., Thetford, Angela, Krausz, Kristopher W., Gonzalez, Frank J., Mitchell, James B., Patterson, Andrew D., 2016

Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction
Die Nahrung, Phillips, Brett E., Geletzke, Abby K., Smith, Philip B., Podany, Abigail B., Chacon, Alexander, Kelleher, Shannon L., Patterson, Andrew D., Soybel, David I., 2016

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota
Journal of Proteome Research, Cai, Jingwei, Zhang, Limin, Jones, Richard A., Correll, Jared B., Hatzakis, Emmanuel, Smith, Philip B., Gonzalez, Frank J., Patterson, Andrew D., 2016

Reversing methanogenesis to capture methane for liquid biofuel precursors
Microbial Cell Factories, Soo, Valerie W.C., McAnulty, Michael J., Tripathi, Arti, Zhu, Fayin, Zhang, Limin, Hatzakis, Emmanuel, Smith, Philip B., Agrawal, Saumya, Nazem-Bokaee, Hadi, Gopalakrishnan, Saratram, Salis, Howard M., Ferry, James G., Maranas, Costas D., Patterson, Andrew D., Wood, Thomas K., 2016

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota
J Proteome Res, Cai, J., Zhang, L., Jones, R., Correll, J., Hatzakis, E., Smith, P., Gonzalez, F., Patterson, Andrew, 2016

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Nature Communications, Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shi, Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., Gonzalez, Frank J., 2015

Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data
BMC Bioinformatics, Zhan, Xiang, Patterson, Andrew David, Ghosh, Debashis, 2015

Lack of soluble fiber drives diet-induced adiposity in mice
American Journal of Physiology, Chassaing, Benoit, Miles-Brown, Jennifer, Pellizzon, Michael, Ulman, Edward, Ricci, Matthew, Zhang, Limin, Patterson, Andrew D., Vijay-Kumar, Matam, Gewirtz, Andrew T., 2015

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
Scientific Reports, Hubbard, Troy D., Murray, Iain A., Bisson, William H., Lahoti, Tejas S., Gowda, Krishne, Amin, Shantu G., Patterson, Andrew D., Perdew, Gary H., 2015

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice
Environmental Science & Technology, Zhang, Limin, Hatzakis, Emmanuel, Nichols, Robert G., Hao, Ruixin, Correll, Jared, Smith, Philip B., Chiaro, Christopher R., Perdew, Gary H., Patterson, Andrew D., 2015

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Environmental Health Perspectives, Zhang, Limin, Nichols, Robert G., Correll, Jared, Murray, Iain A., Tanaka, Naoki, Smith, Philip B., Hubbard, Troy D., Sebastian, Aswathy, Albert, Istvan, Hatzakis, Emmanuel, Gonzalez, Frank J., Perdew, Gary H., Patterson, Andrew D., 2015

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
Biochimica et Biophysica Acta - Molecular Basis of Disease, Tanaka, Naoki, Takahashi, Shogo, Zhang, Yuan, Krausz, Kristopher W., Smith, Philip B., Patterson, Andrew D., Gonzalez, Frank J., 2015

Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity
Journal of Hepatology, Gonzalez, Frank J., Jiang, Changtao, Bisson, William H., Patterson, Andrew David, 2015

Modulation of colon cancer by nutmeg
Journal of Proteome Research, Li, Fei, Yang, Xiu Wei, Krausz, Kristopher W., Nichols, Robert G., Xu, Wei, Patterson, Andrew David, Gonzalez, Frank J., 2015

Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis
Journal of Biological Chemistry, Zhao, Hong, Chiaro, Christopher R., Zhang, Limin, Smith, Philip B., Chan, Chung Yu, Pedley, Anthony M., Pugh, Raymond J., French, Jarrod B., Patterson, Andrew D., Benkovic, Stephen J., 2015

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Journal of Clinical Investigation, Jiang, Changtao, Xie, Cen, Li, Fei, Zhang, Limin, Nichols, Robert G., Krausz, Kristopher W., Cai, Jingwei, Qi, Yunpeng, Fang, Zhong Ze, Takahashi, Shogo, Tanaka, Naoki, Desai, Dhimant, Amin, Shantu G., Albert, Istvan, Patterson, Andrew D., Gonzalez, Frank J., 2015

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice
Cell Metabolism, Singh, Vishal, Chassaing, Benoit, Zhang, Limin, San Yeoh, Beng, Xiao, Xia, Kumar, Manish, Baker, Mark T., Cai, Jingwei, Walker, Rachel, Borkowski, Kamil, Harvatine, Kevin J., Singh, Nagendra, Shearer, Gregory C., Ntambi, James M., Joe, Bina, Patterson, Andrew D., Gewirtz, Andrew T., Vijay-Kumar, Matam, 2015

Aryl hydrocarbon receptor ligands in cancer
Nature Reviews Cancer, Murray, Iain A., Patterson, Andrew D., Perdew, Gary H., 2014

Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology
Cell Metabolism, Patterson, Andrew D., Turnbaugh, Peter J., 2014

Crucial role of macrophage selenoproteins in experimental colitis
Journal of Immunology, Kaushal, Naveen, Kudva, Avinash K., Patterson, Andrew D., Chiaro, Christopher, Kennett, Mary J., Desai, Dhimant, Amin, Shantu, Carlson, Bradley A., Cantorna, Margherita T., Prabhu, K. Sandeep, 2014

Species-specific ant brain manipulation by a specialized fungal parasite
BMC Evolutionary Biology, De Bekker, Charissa, Quevillon, Lauren E., Smith, Philip B., Fleming, Kimberly R., Ghosh, Debashis, Patterson, Andrew David, Hughes, David Peter, 2014

Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer
Cancer Research, Mathé, Ewy A., Patterson, Andrew D., Haznadar, Majda, Manna, Soumen K., Krausz, Kristopher W., Bowman, Elise D., Shields, Peter G., Idle, Jeffrey R., Smith, Philip B., Anami, Katsuhiro, Kazandjian, Dickran G., Hatzakis, Emmanuel, Gonzalez, Frank J., Harris, Curtis C., 2014

Metabolomics, Belton, Belton R., Correll, Jared B., Patterson, Andrew D., 2014

Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease
Journal of Translational Medicine, Li, Heng Hong, Doiron, Kathryn, Patterson, Andrew D., Gonzalez, Frank J., Fornace, Albert J., 2013

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Nature Communications, Li, Fei, Jiang, Changtao, Krausz, Kristopher W., Li, Yunfei, Albert, Istvan, Hao, Haiping, Fabre, Kristin M., Mitchell, James B., Patterson, Andrew D., Gonzalez, Frank J., 2013

Metabolomics Reveals the Heterogeneous Secretome of Two Entomopathogenic Fungi to Ex Vivo Cultured Insect Tissues
PLoS One, de Bekker, Charissa, Smith, Philip B., Patterson, Andrew D., Hughes, David P., 2013

Metabolomics reveals that tumor xenografts induce liver dysfunction
Molecular and Cellular Proteomics, Li, Fei, Patterson, Andrew D., Krausz, Kristopher W., Jiang, Changtao, Bi, Huichang, Sowers, Anastasia L., Cook, John A., Mitchell, James B., Gonzalez, Frank J., 2013

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity
Chemical Research in Toxicology, Patterson, Andrew David, Carlson, Bradley A., Li, Fei, Bonzo, Jessica A., Yoo, Min Hyuk, Krausz, Kristopher W., Conrad, Marcus, Chen, Chi, Gonzalez, Frank J., Hatfield, Dolph L., 2013

cbiochemistry and physiology of the β class carbonic anhydrase (Cpb) from clostridium perfringens strain 13
Journal of Bacteriology, Siva Sai Kumar, R., Hendrick, William, Correll, Jared B., Patterson, Andrew David, Melville, Stephen B., Ferry, James Gregory, 2013

White Button mushrooms increase microbialdiversity and accelerate the resolution of Citrobacter rodentium infection in mice
Journal of Nutrition, Varshney, Jyotika, Ooi, Jot Hui, Jayarao, Bhushan M., Albert, Istvan, Fisher, Jenny, Smith, Rhonda L., Patterson, Andrew D., Cantorna, Margherita T., 2013

Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism
Journal of Proteome Research, Li, Fei, Pang, Xiaoyan, Krausz, Kristopher W., Jiang, Changtao, Chen, Chi, Cook, John A., Krishna, Murali C., Mitchell, James B., Gonzalez, Frank J., Patterson, Andrew David, 2013

Metabolomics
Toxicologic Pathology, Montanez, Jessica E., Peters, Jeffrey M., Correll, Jared B., Gonzalez, Frank J., Patterson, Andrew D., 2013

Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis
Cell Metabolism, Matsubara, Tsutomu, Tanaka, Naoki, Krausz, Kristopher W., Manna, Soumen K., Kang, Dong Wook, Anderson, Erik R., Luecke, Hans, Patterson, Andrew D., Shah, Yatrik M., Gonzalez, Frank J., 2012

Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier
PLoS Genetics, Menezes, Luis F., Zhou, Fang, Patterson, Andrew D., Piontek, Klaus B., Krausz, Kristopher W., Gonzalez, Frank J., Germino, Gregory G., 2012

Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics
Radiation Research, Johnson, Caroline H., Patterson, Andrew David, Krausz, Kristopher W., Kalinich, John F., Tyburski, John B., Kang, Dong Wook, Luecke, Hans, Gonzalez, Frank J., Blakely, William F., Idle, Jeffrey R., 2012

Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics
American Journal of Clinical Nutrition, Johnson, Caroline H., Slanař, Ondřej, Krausz, Kristopher W., Kang, Dong Wook, Patterson, Andrew David, Kim, Jung Hwan, Luecke, Hans, Gonzalez, Frank J., Idle, Jeffrey R., 2012

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver
Toxicological Sciences, Tanos, Rachel, Murray, Iain A., Smith, Philip B., Patterson, Andrew, Perdew, Gary H., 2012

Metabolomics reveals an essential role for peroxisome proliferator- activated receptor α in bile acid homeostasis
Journal of Lipid Research, Li, Fei, Patterson, Andrew D., Krausz, Kristopher W., Tanaka, Naoki, Gonzalez, Frank J., 2012

Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice
Journal of Biological Chemistry, Zhang, Yuanyuan, Li, Fei, Patterson, Andrew D., Wang, Yao, Krausz, Kristopher W., Neale, Geoffrey, Thomas, Sarah, Nachagari, Deepa, Vogel, Peter, Vore, Mary, Gonzalez, Frank J., Schuetz, John D., 2012

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
Hepatology, Patterson, Andrew D., Shah, Yatrik M., Matsubara, Tsutomu, Krausz, Kristopher W., Gonzalez, Frank J., 2012

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Hepatology, Tanaka, Naoki, Matsubara, Tsutomu, Krausz, Kristopher W., Patterson, Andrew D., Gonzalez, Frank J., 2012

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner
Hepatology, Tanos, Rachel, Patel, Rushang D., Murray, Iain Alexander, Smith, Philip B., Patterson, Andrew David, Perdew, Gary H., 2012

Metabolomics reveals the metabolic map of procainamide in humans and mice
Biochemical Pharmacology, Li, Fei, Patterson, Andrew D., Krausz, Kristopher W., Dick, Bernhard, Frey, Felix J., Gonzalez, Frank J., Idle, Jeffrey R., 2012

Xenobiotic metabolomics
Annual Review of Pharmacology and Toxicology, Johnson, Caroline H., Patterson, Andrew D., Idle, Jeffrey R., Gonzalez, Frank J., 2012

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling
Cancer Research, Patterson, Andrew David, Maurhofer, Olivier, Beyoǧlu, Diren, Lanz, Christian, Krausz, Kristopher W., Pabst, Thomas, Gonzalez, Frank J., Dufour, Jean François, Idle, Jeffrey R., 2011

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model
Journal of Proteome Research, Manna, Soumen K., Patterson, Andrew David, Yang, Qian, Krausz, Kristopher W., Idle, Jeffrey R., Fornace, Albert J., Gonzalez, Frank J., 2011

PPAR action in insulin resistance unraveled by metabolomics
Genome Medicine, Patterson, Andrew D., Peters, Jeffrey M., 2011

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice
Carcinogenesis, Hollander, M. Christine, Zhou, Xin, Maier, Colleen R., Patterson, Andrew D., Ding, Xinxin, Dennis, Phillip A., 2011

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus
Journal of Biological Chemistry, Patterson, Andrew D., Bonzo, Jessica A., Li, Fei, Krausz, Kristopher W., Eichler, Gabriel S., Aslam, Sadaf, Tigno, Xenia, Weinstein, John N., Hansen, Barbara C., Idle, Jeffrey R., Gonzalez, Frank J., 2011

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics
Biochemical Pharmacology, Li, Fei, Patterson, Andrew D., Höfer, Constance C., Krausz, Kristopher W., Gonzalez, Frank J., Idle, Jeffrey R., 2011

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats
Radiation Research, Johnson, Caroline H., Patterson, Andrew D., Krausz, Kristopher W., Lanz, Christian, Kang, Dong Wook, Luecke, Hans, Gonzalez, Frank J., Idle, Jeffrey R., 2011

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice
Hepatology, Matsubara, Tsutomu, Tanaka, Naoki, Patterson, Andrew D., Cho, Joo Youn, Krausz, Kristopher W., Gonzalez, Frank J., 2011