Girish Soorappa Kirimanjeswara, BVSc, MVSc, Ph.D.

Girish Soorappa Kirimanjeswara, BVSc, MVSc, Ph.D.

  • Associate Professor
W205 Millennium Science Complex
University Park, PA 16802

Areas of Expertise

  • Immunologic mechanisms of Bordetella
  • Pathogenesis of Francisella tularensis
  • Host-pathogen interactions
  • Development of BSL-3 research programs

Education

  • Postdoctoral Fellow, Albany Medical College, New York
  • PhD in Pathobiology, Penn State University, Pennsylvania
  • MVSc in Biotechnology, Indian Veterinary Research Institute, Izatnagar, India
  • BVSc, Veterinary Sciences, Bangalore Veterinary College, Bangalore, India

Graduate Programs

  • Pathobiology
  • Immunology and Infectious Disease Emphasis Area, MCIBS

Centers

Research

The Kirimanjeswara lab is focused on characterizing the virulence factors of bacterial pathogens such as Francisella tularensis and Bordetella pertusis, with the goal of developing vaccines. They are particularly interested in factor/s that affect specific innate immune responses, promote survival and replication within a host cell, and facilitate persistence in environment. In addition, they study defense mechanisms involved in initiating innate immune responses, specific cells involved in clearing the parasites and/or facilitating the restriction of parasites, and the influence of environmental factors on the outcome of a host-parasite interactions and bacterial infections. 

Publications

Differential immune response following intranasal and intradermal infection with francisella tularensis
Microorganisms, Nicol, McKayla J., Williamson, David R., Place, David E., Kirimanjeswara, Girish S., 2021

Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species
Scientific Reports, Nicol, McKayla K.J., Brubaker, Timothy R., Honish, Brian J., Simmons, Alyssa N., Kazemi, Ali, Geissel, Madison A., Whalen, Connor T., Siedlecki, Christopher A., Bilén, Sven G., Knecht, Sean D., Kirimanjeswara, Girish S., 2020

Role of selenoproteins in bacterial pathogenesis
Biological Trace Element Research, Sumner, Sarah E., Markley, Rachel L., Kirimanjeswara, Girish S., 2019

The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages
Gut Microbes, Saha, Piu, Xiao, Xia, Yeoh, Beng San, Chen, Qiuyan, Katkere, Bhuvana, Kirimanjeswara, Girish Soorappa, Vijay-Kumar, Matam, 2019

Re
Investigative Urology, Qi, D. Z., Lehman, K., Dewan, K., Kirimanjeswara, G., Raman, J. D., 2019

Cross Sectional Study and Risk Factors Analysis of Francisella tularensis in Soil Samples in Punjab Province of Pakistan
Frontiers in cellular and infection microbiology, Muhammad, Javed, Rabbani, Masood, Shabbir, Muhammad Zubair, Muhammad, Khushi, Ghori, Muhammad Taslim, Chaudhry, Haroon Rashid, Hassnain, Zia Ul, Jamil, Tariq, Abbas, Tariq, Chaudhry, Muhammad Hamid, Haisem-Ur-Rasool, Muhammad, Ali, Muhammad Asad, Nisar, Muhammad, Kirimanjeswara, Girish S., Jayarao, Bhushan M., 2019

A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes
mBio, Goralski, Tyler D.P., Kirimanjeswara, Girish S., Keiler, Kenneth C., 2018

Topical rectal antiseptic at time of prostate biopsy: how a resident patient safety project has evolved into institutional practice
International Urology and Nephrology, Park, Rosa, Gyorfi, Justin, Dewan, Kalyan, Kirimanjeswara, Girish, Clark, Joseph Y., Kaag, Matthew G., Lehman, Kathleen, Raman, Jay D., 2018

A single mechanosensitive channel protects Francisella tularensis subsp. holarctica from hypoosmotic shock and promotes survival in the aquatic environment
Applied and Environmental Microbiology, Williamson, David R., Dewan, Kalyan K., Patel, Tanmay, Wastella, Catherine M., Ning, Gang, Kirimanjeswara, Girish S., 2018

Preoperative urine culture is unnecessary in asymptomatic men prior to prostate needle biopsy
International Urology and Nephrology, Qi, David Z., Lehman, Kathleen, Dewan, Kalyan, Kirimanjeswara, Girish, Raman, Jay D., 2018

Development of a novel Francisella tularensis live vaccine strain expressing ovalbumin provides insight into antigen-specific CD8+ T cell responses
PLoS One, Place, David E., Williamson, David R., Yuzefpolskiy, Yevgeniy, Katkere, Bhuvana, Sarkar, Surojit, Kalia, Vandana, Kirimanjeswara, Girish S., 2017

Defective anti-polysaccharide IgG vaccine responses in IgA deficient mice
Vaccine, Furuya, Yoichi, Kirimanjeswara, Girish S., Roberts, Sean, Racine, Rachael, Wilson-Welder, Jennifer, Sanfilippo, Alan M., Salmon, Sharon L., Metzger, Dennis W., 2017

Procedural povidone iodine rectal preparation reduces bacteriuria and bacteremia following prostate needle biopsy
Canadian Journal of Urology, Allen, Jordan L., Lehman, Kathleen, Dewan, Kalyan, Kirimanjeswara, Girish, Raman, Jay D., 2017

Lipopolysacharide gene based development and optimization of diagnostics for francisella tularensis
Journal of Animal and Plant Sciences, Muhammad, J., Rabbani, M., Muhammad, K., Wasim, M., Dewan, K., Anjum, A. A., Sheikh, A. A., Ahmad, A., Akhtar, F., Nisar, M., Jayarao, B. M., Kirimanjeswara, G. S., 2017

Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication
Antimicrobial Agents and Chemotherapy, Goralski, Tyler D.P., Dewan, Kalyan K., Alumasa, John N., Avanzato, Victoria, Place, David E., Markley, Rachel L., Katkere, Bhuvana, Rabadi, Seham M., Bakshi, Chandra Shekhar, Keiler, Kenneth C., Kirimanjeswara, Girish S., 2016

Povidone iodine rectal preparation at time of prostate needle biopsy is a simple and reproducible means to reduce risk of procedural infection
Journal of Visualized Experiments, Raman, Jay D., Lehman, Kathleen K., Dewan, Kalyan, Kirimanjeswara, Girish, 2015

Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity
PLoS One, Place, David E., Muse, Sarah J., Kirimanjeswara, Girish S., Harvill, Eric T., 2014

Peri-procedural povidone-iodine rectal preparation reduces microorganism counts and infectious complications following ultrasound-guided needle biopsy of the prostate
World Journal of Urology, Gyorfi, Justin R., Otteni, Christopher, Brown, Kevin, Patel, Amar, Lehman, Kathleen, Phillips, Brett E., Dewan, Kalyan, Kirimanjeswara, Girish, Raman, Jay D., 2014

Increased susceptibility of IgA-deficient mice to pulmonary francisella tularensis live vaccine strain infection
Infection and Immunity, Furuya, Yoichi, Kirimanjeswara, Girish S., Roberts, Sean, Metzger, Dennis W., 2013

Differing effects of interleukin-10 on cutaneous and pulmonary francisella tularensis live vaccine strain infection
Infection and Immunity, Metzger, Dennis W., Salmon, Sharon L., Kirimanjeswara, Girish, 2013

Intranasal administration of an inactivated Yersinia pestis vaccine with interleukin-12 generates protective immunity against pneumonic plague
Clinical and Diagnostic Laboratory Immunology, Kumar, Devender, Kirimanjeswara, Girish, Metzger, Dennis W., 2011

Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia
Vaccine, Hickey, Anthony J., Hazlett, Karsten R.O., Kirimanjeswara, Girish S., Metzger, Dennis W., 2011