Girish Soorappa Kirimanjeswara, BVSc, MVSc, Ph.D.

Girish Soorappa Kirimanjeswara, BVSc, MVSc, Ph.D.

  • Associate Professor
207 AVBS Building
Shortlidge Road

University Park, PA 16802

Areas of Expertise

  • Immunologic mechanisms of Bordetella
  • Pathogenesis of Francisella tularensis
  • Host-pathogen interactions
  • Development of BSL-3 research programs


  • Postdoctoral Fellow, Albany Medical College, New York
  • PhD in Pathobiology, Penn State University, Pennsylvania
  • MVSc in Biotechnology, Indian Veterinary Research Institute, Izatnagar, India
  • BVSc, Veterinary Sciences, Bangalore Veterinary College, Bangalore, India

Graduate Programs

  • Pathobiology
  • Immunology and Infectious Disease Emphasis Area, MCIBS



The Kirimanjeswara lab is focused on characterizing the virulence factors of bacterial pathogens such as Francisella tularensis and Bordetella pertusis, with the goal of developing vaccines. They are particularly interested in factor/s that affect specific innate immune responses, promote survival and replication within a host cell, and facilitate persistence in environment. In addition, they study defense mechanisms involved in initiating innate immune responses, specific cells involved in clearing the parasites and/or facilitating the restriction of parasites, and the influence of environmental factors on the outcome of a host-parasite interactions and bacterial infections. 


Cold Atmospheric Plasma Medicine: Applications, Challenges, and Opportunities for Predictive Control
Plasma, Nicol, McKayla, Kazemi, Ali, Nicol, Mckayla, Kazemi, Ali, Bilén, Sven G., Kirimanjeswara, Girish S., Bilén, S, Knecht, Sean D., Kirimanjeswara, G, 2024

DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 mice
Frontiers in Immunology, Persson, Gry, Restori, Katherine H., Emdrup, Julie Hincheli, Schussek, Sophie, Klausen, Michael Schantz, Nicol, McKayla J., Katkere, Bhuvana, Rønø, Birgitte, Kirimanjeswara, Girish, Sørensen, Anders Bundgaard, 2023

The role of selenoproteins in neutrophils during inflammation
Archives of Biochemistry and Biophysics, Lee, Tai Jung, Nettleford, Shaneice K., McGlynn, Allison, Carlson, Bradley A., Kirimanjeswara, Girish S., Prabhu, K. Sandeep, 2022

Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation
Biomacromolecules, Lawanprasert, Atip, Lawanprasert^, Atip, Simonson, Andrew W., Simonson^, Andrew, Sumner, Sarah, Nicol, McKayla, Pimcharoen, Sopida, Pimcharoen^, Sopida, Kirimanjeswara, Girish S., Medina*, Scott, 2022

Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs
Nutrients, Arora, Juhi, Patel, Devanshi, Nicol, McKayla, Field, Cassandra, Restori, Katherine, Wang, Jinpeng, Froelich, Nicole, Katkere, Bhuvana, Terwilliger, Josey, Weaver, Veronika, others, None, Luley, Erin, Kelly, Kathleen, Kirimanjeswara, Girish S., Sutton, Troy, Cantorna, Margherita T., 2022

Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation
Small, Lawanprasert, Atip, Pimcharoen, Sopida, Sumner, Sarah E., Watson, Connor T., Manning, Keefe B., Kirimanjeswara, Girish S., Medina, Scott H., 2022

Differential immune response following intranasal and intradermal infection with francisella tularensis: Implications for vaccine development
Microorganisms, Nicol, McKayla J., Williamson, David R., Place, David E., Kirimanjeswara, Girish S., 2021

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity
Frontiers in Immunology, Markley, Rachel, Restori, Katherine, Katkere, Bhuvana, Sumner, Sarah, Nicol, McKayla, Tyryshkina, Anastasia, Nettleford, Shaneice, Williamson, David, Place, David, Dewan, Kalyan, Shay, Ashley, others, None, Carlson, Bradley, Girirajan, Santhosh, Prabhu, K. Sandeep, Kirimanjeswara, Girish S., 2021

Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species
Scientific Reports, Nicol, M, Brubaker, T, Honish, 2nd, B, Honish, Brian J., Simmons, A, Kazemi, A, Geissel, M, Whalen, C, Siedlecki, Christopher, Bilen, S, Bilén, Sven G., Knecht, S, Kirimanjeswara, Girish S., 2020

Influence of Dielectric Coatings on Pin-to-Rod Nanosecond-Pulsed Discharges in Phosphate-Buffered Saline
IEEE Transactions on Radiation and Plasma Medical Sciences, Brubacker, Timothy, Brubaker, Timothy, Nicol, McKayla, Kirimanjeswara, Girish Soorapp, Siedlecki, Christopher, Kazemi, Ali, Snyder, Philip, Synder, Philip, Bilen, S, Bilén, Sven, Knetch, Sean, Knecht, Sean, 2020

Role of Selenoproteins in Bacterial Pathogenesis
Biological Trace Element Research, Sumner, Sarah E., Markley, Rachel L., Kirimanjeswara, Girish S., 2019

Re: Preoperative urine culture is unnecessary in asymptomatic men prior to prostate needle biopsy
Investigative Urology, Qi, D. Z., Lehman, K., Dewan, K., Kirimanjeswara, G., Raman, J. D., 2019

The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages
Gut Microbes, Saha, P, Xiao, Xia, Yeoh, Beng, Chen, Q, Katkere, Bhuvana, Kirimanjeswara, Girish Soorappa, Vijay-Kumar, Matam, 2019

Cross Sectional Study and Risk Factors Analysis of Francisella tularensis in Soil Samples in Punjab Province of Pakistan
Frontiers in cellular and infection microbiology, Muhammad, J, Rabbani, M, Shabbir, M, Muhammad, K, Ghori, M, Chaudhry, H, Ul Hassnain, Z, Hassnain, Zia Ul, Jamil, T, Abbas, T, Chaudhry, M, Haisem-Ur-Rasool, M, Ali, M, Nisar, M, Kirimanjeswara, Girish S., Jayarao, Bhushan M., 2019

A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes
mBio, Goralski, Tyler D.P., Kirimanjeswara, Girish S., Keiler, Kenneth C., 2018

Topical rectal antiseptic at time of prostate biopsy: how a resident patient safety project has evolved into institutional practice
International Urology and Nephrology, Park, Rosa, Gyorfi, Justin, Dewan, Kalyan, Kirimanjeswara, Girish, Clark, Joseph Y., Kaag, Matthew, Lehman, Kathleen, Raman, Jay, 2018

A single mechanosensitive channel protects Francisella tularensis subsp. holarctica from hypoosmotic shock and promotes survival in the aquatic environment
Applied and Environmental Microbiology, Williamson, David R., Dewan, Kalyan K., Patel, Tanmay, Wastella, Catherine M., Ning, Gang, Kirimanjeswara, Girish S., 2018

Preoperative urine culture is unnecessary in asymptomatic men prior to prostate needle biopsy
International Urology and Nephrology, Qi, D, Lehman, K, Dewan, K, Kirimanjeswara, Girish, Raman, Jay D., 2018

Defective anti-polysaccharide IgG vaccine responses in IgA deficient mice
Vaccine, Furuya, Yoichi, Kirimanjeswara, Girish S., Roberts, Sean, Racine, Rachael, Wilson-Welder, Jennifer, Sanfilippo, Alan M., Salmon, Sharon L., Metzger, Dennis W., 2017

Procedural povidone iodine rectal preparation reduces bacteriuria and bacteremia following prostate needle biopsy
Canadian Journal of Urology, Allen, Jordan L., Lehman, Kathleen, Dewan, Kalyan, Kirimanjeswara, Girish, Raman, Jay D., 2017

Lipopolysacharide gene based development and optimization of diagnostics for francisella tularensis
Journal of Animal and Plant Sciences, Muhammad, J., Rabbani, M., Muhammad, K., Wasim, M., Dewan, K., Anjum, A. A., Sheikh, A. A., Ahmad, A., Akhtar, F., Nisar, M., Jayarao, B. M., Kirimanjeswara, G. S., 2017

Development of a novel Francisella tularensis live vaccine strain expressing ovalbumin provides insight into antigen-specific CD8+ T cell responses
PLoS One, Place, David, Williamson, D, Yuzefpolskiy, Yevgeniy, Katkere, Bhuvana, Sarkar, S, Kalia, V, Kirimanjeswara, Girish S., 2017

Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication
Antimicrobial Agents and Chemotherapy, Goralski, Tyler, Dewan, Kalyan, Alumasa, John N., Avanzato, Victoria, Place, David, Markley, Rachel, Katkere, Bhuvana, Rabadi, Seham, Bakshi, Chandra, Keiler, Kenneth C., Kirimanjeswara, Girish S., others, None, 2016

Selenium for the Millennium: A Whooping Trace Element
MicroTalk Podacst Series: South Texas Center for Emerging Infectious Diseases, Kirimanjeswara, Girish, 2016

Povidone iodine rectal preparation at time of prostate needle biopsy is a simple and reproducible means to reduce risk of procedural infection
Journal of Visualized Experiments, Raman, Jay, Lehman, K, Dewan, K, Kirimanjeswara, Girish, 2015

Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity
PLoS One, Place, David E., Muse, Sarah J., Kirimanjeswara, Girish S., Harvill, Eric T., 2014

Peri-procedural povidone-iodine rectal preparation reduces microorganism counts and infectious complications following ultrasound-guided needle biopsy of the prostate
World Journal of Urology, Gyorfi, J, Otteni, C, Brown, K, Patel, A, Lehman, K, Phillips, B, Dewan, K, Kirimanjeswara, Girish, Raman, Jay D., 2014