Girish Soorappa Kirimanjeswara, BVSc, MVSc, Ph.D.
- Associate Professor
Shortlidge Road
University Park, PA 16802
- Email gsk125@psu.edu
- Office 814-863-5250
Areas of Expertise
- Immunologic mechanisms of Bordetella
- Pathogenesis of Francisella tularensis
- Host-pathogen interactions
- Development of BSL-3 research programs
Education
- Postdoctoral Fellow, Albany Medical College, New York
- PhD in Pathobiology, Penn State University, Pennsylvania
- MVSc in Biotechnology, Indian Veterinary Research Institute, Izatnagar, India
- BVSc, Veterinary Sciences, Bangalore Veterinary College, Bangalore, India
Graduate Programs
- Pathobiology
- Immunology and Infectious Disease Emphasis Area, MCIBS
Centers
- Member of the Center for Infectious Disease Dynamics (CIDD).
- Member of the Center for Molecular Immunology and Infectious Disease (CMIID).
Research
The Kirimanjeswara lab is focused on characterizing the virulence factors of bacterial pathogens such as Francisella tularensis and Bordetella pertusis, with the goal of developing vaccines. They are particularly interested in factor/s that affect specific innate immune responses, promote survival and replication within a host cell, and facilitate persistence in environment. In addition, they study defense mechanisms involved in initiating innate immune responses, specific cells involved in clearing the parasites and/or facilitating the restriction of parasites, and the influence of environmental factors on the outcome of a host-parasite interactions and bacterial infections.
Publications
The role of selenoproteins in neutrophils during inflammation
Archives of Biochemistry and Biophysics, Lee, Tai Jung, Nettleford, Shaneice K., McGlynn, Allison, Carlson, Bradley A., Kirimanjeswara, Girish S., Prabhu, K. Sandeep, 2022
Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs
Nutrients, Arora, J, Patel, D, Nicol, M, Field, C, Restori, Katherine, Wang, J, Froelich, N, Katkere, B, Terwilliger, J, Weaver, V, Luley, Erin, Kelly, Kathleen, Kirimanjeswara, Girish S., Sutton, Troy, Cantorna, Margherita T., 2022
Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation
Biomacromolecules, Lawanprasert, Atip, Lawanprasert^, Atip, Simonson, Andrew W., Simonson^, Andrew, Sumner, Sarah, Nicol, McKayla, Pimcharoen, Sopida, Pimcharoen^, Sopida, Kirimanjeswara, Girish S., Medina*, Scott, 2022
Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation
Small, Lawanprasert, Atip, Pimcharoen, Sopida, Sumner, Sarah E., Watson, Connor T., Manning, Keefe B., Kirimanjeswara, Girish S., Medina, Scott H., 2022
Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity
Frontiers in Immunology, Markley, Rachel, Restori, Katherine, Katkere, Bhuvana, Sumner, Sarah, Nicol, McKayla, Tyryshkina, Anastasia, Nettleford, Shaneice, Williamson, David, Place, David, Dewan, Kalyan, Shay, Ashley, Carlson, Bradley, Girirajan, Santhosh, Prabhu, K. Sandeep, Kirimanjeswara, Girish S., 2021
Differential immune response following intranasal and intradermal infection with francisella tularensis: Implications for vaccine development
Microorganisms, Nicol, McKayla J., Williamson, David R., Place, David E., Kirimanjeswara, Girish S., 2021
Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species
Scientific Reports, Nicol, M, Brubaker, T, Honish, 2nd, B, Honish, Brian J., Simmons, A, Kazemi, A, Geissel, M, Whalen, C, Siedlecki, Christopher, Bilen, S, Bilén, Sven G., Knecht, S, Kirimanjeswara, Girish S., 2020
Influence of Dielectric Coatings on Pin-to-Rod Nanosecond-Pulsed Discharges in Phosphate-Buffered Saline
IEEE Transactions on Radiation and Plasma Medical Sciences, Brubacker, Timothy, Brubaker, Timothy, Nicol, McKayla, Kirimanjeswara, Girish Soorapp, Siedlecki, Christopher, Kazemi, Ali, Snyder, Philip, Synder, Philip, Bilen, S, Bilén, Sven, Knetch, Sean, Knecht, Sean, 2020
Role of Selenoproteins in Bacterial Pathogenesis
Biological Trace Element Research, Sumner, Sarah E., Markley, Rachel L., Kirimanjeswara, Girish S., 2019
The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages
Gut Microbes, Saha, Piu, Xiao, Xia, Yeoh, Beng San, Chen, Qiuyan, Katkere, Bhuvana, Kirimanjeswara, Girish Soorappa, Vijay-Kumar, Matam, 2019
Re: Preoperative urine culture is unnecessary in asymptomatic men prior to prostate needle biopsy
Investigative Urology, Qi, D. Z., Lehman, K., Dewan, K., Kirimanjeswara, G., Raman, J. D., 2019
Cross Sectional Study and Risk Factors Analysis of Francisella tularensis in Soil Samples in Punjab Province of Pakistan
Frontiers in cellular and infection microbiology, Muhammad, J, Rabbani, M, Shabbir, M, Muhammad, K, Ghori, M, Chaudhry, H, Ul Hassnain, Z, Hassnain, Zia Ul, Jamil, T, Abbas, T, Chaudhry, M, Haisem-Ur-Rasool, M, Ali, M, Nisar, M, Kirimanjeswara, Girish S., Jayarao, Bhushan M., 2019
A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes
mBio, Goralski, Tyler D.P., Kirimanjeswara, Girish S., Keiler, Kenneth C., 2018
Topical rectal antiseptic at time of prostate biopsy: how a resident patient safety project has evolved into institutional practice
International Urology and Nephrology, Park, Rosa, Gyorfi, Justin, Dewan, Kalyan, Kirimanjeswara, Girish, Clark, Joseph Y., Kaag, Matthew, Lehman, Kathleen, Raman, Jay, 2018
A single mechanosensitive channel protects Francisella tularensis subsp. holarctica from hypoosmotic shock and promotes survival in the aquatic environment
Applied and Environmental Microbiology, Williamson, David R., Dewan, Kalyan K., Patel, Tanmay, Wastella, Catherine M., Ning, Gang, Kirimanjeswara, Girish S., 2018
Preoperative urine culture is unnecessary in asymptomatic men prior to prostate needle biopsy
International Urology and Nephrology, Qi, D, Lehman, K, Dewan, K, Kirimanjeswara, Girish, Raman, Jay D., 2018
Development of a novel Francisella tularensis live vaccine strain expressing ovalbumin provides insight into antigen-specific CD8+ T cell responses
PLoS One, Place, David E., Williamson, David R., Yuzefpolskiy, Yevgeniy, Katkere, Bhuvana, Sarkar, Surojit, Kalia, Vandana, Kirimanjeswara, Girish S., 2017
Defective anti-polysaccharide IgG vaccine responses in IgA deficient mice
Vaccine, Furuya, Yoichi, Kirimanjeswara, Girish S., Roberts, Sean, Racine, Rachael, Wilson-Welder, Jennifer, Sanfilippo, Alan M., Salmon, Sharon L., Metzger, Dennis W., 2017
Procedural povidone iodine rectal preparation reduces bacteriuria and bacteremia following prostate needle biopsy
Canadian Journal of Urology, Allen, Jordan L., Lehman, Kathleen, Dewan, Kalyan, Kirimanjeswara, Girish, Raman, Jay D., 2017
Lipopolysacharide gene based development and optimization of diagnostics for francisella tularensis
Journal of Animal and Plant Sciences, Muhammad, J., Rabbani, M., Muhammad, K., Wasim, M., Dewan, K., Anjum, A. A., Sheikh, A. A., Ahmad, A., Akhtar, F., Nisar, M., Jayarao, B. M., Kirimanjeswara, G. S., 2017
Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication
Antimicrobial Agents and Chemotherapy, Goralski, Tyler D.P., Dewan, Kalyan K., Alumasa, John N., Avanzato, Victoria, Place, David E., Markley, Rachel L., Katkere, Bhuvana, Rabadi, Seham M., Bakshi, Chandra Shekhar, Keiler, Kenneth C., Kirimanjeswara, Girish S., 2016
Selenium for the Millennium: A Whooping Trace Element
MicroTalk Podacst Series: South Texas Center for Emerging Infectious Diseases, Kirimanjeswara, Girish, 2016
Povidone iodine rectal preparation at time of prostate needle biopsy is a simple and reproducible means to reduce risk of procedural infection
Journal of Visualized Experiments, Raman, Jay, Lehman, K, Dewan, K, Kirimanjeswara, Girish, 2015
Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity
PLoS One, Place, David E., Muse, Sarah J., Kirimanjeswara, Girish S., Harvill, Eric T., 2014
Peri-procedural povidone-iodine rectal preparation reduces microorganism counts and infectious complications following ultrasound-guided needle biopsy of the prostate
World Journal of Urology, Gyorfi, J, Otteni, C, Brown, K, Patel, A, Lehman, K, Phillips, B, Dewan, K, Kirimanjeswara, Girish, Raman, Jay D., 2014
Increased susceptibility of IgA-deficient mice to pulmonary francisella tularensis live vaccine strain infection
Infection and Immunity, Furuya, Yoichi, Kirimanjeswara, Girish S., Roberts, Sean, Metzger, Dennis W., 2013
Differing effects of interleukin-10 on cutaneous and pulmonary francisella tularensis live vaccine strain infection
Infection and Immunity, Metzger, Dennis W., Salmon, Sharon L., Kirimanjeswara, Girish, 2013
