Huaguang Lu, DVM, MS, MPVM

Huaguang Lu, DVM, MS, MPVM

  • Clinical Professor
  • Avian Virologist
  • Section Head, Avian Virology
Animal Diagnostic Lab (ADL), Avian Virology
Wiley Lane

University Park, PA 16802

Areas of Expertise

  • Avian Virology- Isolation/Identification of Various Avian Viruses
  • Animal Models for Pathogenicity and Vaccine-Challenge Studies
  • Avian Influenza Virus Monoclonal Antibodies & Assays Development
  • Avian Reovirus Genotyping and Full Genomic Characterizations
  • NGS-Next Generation Sequencing in Diagnostic Virology
  • Molecular & Monoclonal-based Virology Assays Development
  • Biosensor and Nanotechnology Assays in Virus Detection

Education

  • MS, Comparative Pathol­ogy, School of Veterinary Medicine, University of California, Davis, CA, 1987
  • MPVM, Preventive Veterinary Medicine, School of Veterinary Medicine, University of California, Davis, CA, 1986
  • DVM, Department of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning Province, China, 1982

Current Diagnostic Activities

  • Providing supervision for daily operation of the avian virology section at Wiley laboratory
  • Training laboratory staff and new personnel on diagnostic virology techniques
  • Conducting isolation of various avian viruses in embryonating chicken eggs and cell  cultures, and virus detection and identification by FA/IFA, AGID, HA/HI tests, various immunoassays, molecular and monoclonal antibody-based assays, and other diagnostic tests
  • Coordinating Pennsylvania avian influenza surveillance program and conducting real-time RT-PCR for detecting AIV, H5 and H7 subtypes, paramyxovirus type 1 (PMV-1/NDV), and variant NDV
  • Providing case coordination for submissions of avian virology cases
  • Developing new diagnostic tests and SOPs
  • Manager of Wiley biocontainment facility to support diagnostic research and disease investigations

Publications

A rapid and label-free platform for virus capture and identification from clinical samples.
Proceedings of the National Academy of Sciences of the United States of America, Yeh, Yin-Ting, Gulino, K, Zhang, Yu, Sabestien, A, Chou, T, Zhou, B, Lin, Zhenwu, Albert, Istvan, Lu, Huaguang, Swaminathan, V, Ghedin, E, Terrones Maldonado, Mauricio, 2020

Smartphone-Based Point-of-Care Microfluidic Platform Fabricated with a ZnO Nanorod Template for Colorimetric Virus Detection
ACS Sensors, Xia, Yiqiu, Chen, Yizhu, Tang, Yeming, Cheng, Gong, Yu, Xu, He, Hongzhang, Cao, Guohong, Lu, Huaguang, Liu, Zhiwen, Zheng, Si Yang, 2019

A Nanostructured Microfluidic Immunoassay Platform for Highly Sensitive Infectious Pathogen Detection
Small, Yu, Xu, Xia, Yiqiu, Tang, Yi, Zhang, Wen Long, Yeh, Yin Ting, Lu, Huaguang, Zheng, Si Yang, 2017

A nanowell-based QCM aptasensor for rapid and sensitive detection of avian influenza virus
Sensors and Actuators, B: Chemical, Wang, Ronghui, Wang, Lijun, Callaway, Zachary T., Lu, Huaguang, Huang, Tony Jun, Li, Yanbin, 2017

Label-Free Virus Capture and Release by a Microfluidic Device Integrated with Porous Silicon Nanowire Forest
Small, Xia, Yiqiu, Tang, Yi, Yu, Xu, Wan, Yuan, Chen, Yizhu, Lu, Huaguang, Zheng, Si Yang, 2017

Rapid detection of avian influenza virus H5N1 in chicken tracheal samples using an impedance aptasensor with gold nanoparticles for signal amplification
Journal of Virological Methods, Karash, Sardar, Wang, Ronghui, Kelso, Lisa, Lu, Huaguang, Huang, Tony Jun, Li, Yanbin, 2016

Detection and characterization of two co-infection variant strains of avian orthoreovirus (ARV) in young layer chickens using next-generation sequencing (NGS)
Scientific reports, Tang, Yi, Lin, Lin, Sebastian, Aswathy, Lu, Huaguang, 2016

Whole genome alignment based one-step real-time RT-PCR for universal detection of avian orthoreoviruses of chicken, pheasant and turkey origins
Infection, Genetics and Evolution, Tang, Yi, Lu, Huaguang, 2016

Genomic characterization of a novel avian arthritis orthoreovirus variant by next-generation sequencing
Archives of Virology, Tang, Yi, Lu, Huaguang, 2015

Isolation and molecular characterization of newly emerging avian reovirus variants and novel strains in Pennsylvania, USA, 2011-2014
Scientific reports, Lu, Huaguang, Tang, Yi, Dunn, Patricia A., Wallner-Pendleton, Eva A., Lin, Lin, Knoll, Eric A., 2015

An impedance aptasensor with microfluidic chips for specific detection of H5N1 avian influenza virus
Sensors (Switzerland), Lum, Jacob, Wang, Ronghui, Hargis, Billy, Tung, Steve, Bottje, Walter, Lu, Huaguang, Li, Yanbin, 2015

Genomic characterization of a turkey reovirus field strain by Next-Generation Sequencing
Infection, Genetics and Evolution, Tang, Yi, Lu, Huaguang, Sebastian, Aswathy, Yeh, Yin-Ting, Praul, Craig A., Albert, Istvan, Zheng, Siyang, 2015

Genomic characterization of a broiler reovirus field strain detected in Pennsylvania
Infection, Genetics and Evolution, Tang, Yi, Lu, Huaguang, 2015

Successful establishment and global dispersal of genotype VI avian paramyxovirus serotype 1 after cross species transmission
Infection, Genetics and Evolution, Chong, Yee Ling, Lam, Tommy Tsan Yuk, Kim, Oekyung, Lu, Huaguang, Dunn, Patty, Poss, Mary, 2013

Selection and characterization of DNA aptamers for use in detection of avian influenza virus H5N1
Journal of Virological Methods, Wang, Ronghui, Zhao, Jingjing, Jiang, Tieshan, Kwon, Young M., Lu, Huaguang, Jiao, Peirong, Liao, Ming, Li, Yanbin, 2013

New outbreaks of H5N1 highly pathogenic avian influenza in domestic poultry and wild birds in Cambodia in 2011
Avian diseases, Theary, Ren, San, Sorn, Davun, Holl, Allal, Lotfi, Lu, Huaguang, 2012

Fingerprinting of poultry isolates of Enterococcus cecorum using three molecular typing methods
Journal of Veterinary Diagnostic Investigation, Wijetunge, Dona Saumya, Dunn, Patricia, Wallner-Pendleton, Eva A., Lintner, Valerie, Lu, Huaguang, Kariyawasam, Subhashinie, 2012

Rapid detection of avian influenza H5N1 virus using impedance measurement of immuno-reaction coupled with RBC amplification
Biosensors and Bioelectronics, Lum, Jacob, Wang, Ronghui, Lassiter, Kentu, Srinivasan, Balaji, Abi-Ghanem, Daad, Berghman, Luc, Hargis, Billy, Tung, Steve, Lu, Huaguang, Li, Yanbin, 2012

A SPR aptasensor for detection of avian influenza virus H5N1
Sensors (Switzerland), Bai, Hua, Wang, Ronghui, Hargis, Billy, Lu, Huaguang, Li, Yanbin, 2012

Evaluation study of a portable impedance biosensor for detection of avian influenza virus
Journal of Virological Methods, Wang, Ronghui, Lin, Jianhan, Lassiter, Kentu, Srinivasan, Balaji, Lin, Lin, Lu, Huaguang, Tung, Steve, Hargis, Billy, Bottje, Walter, Berghman, Luc, Li, Yanbin, 2011

A nanobeads amplified QCM immunosensor for the detection of avian influenza virus H5N1
Biosensors and Bioelectronics, Li, Dujuan, Wang, Jianping, Wang, Ronghui, Li, Yanbin, Abi-Ghanem, Daad, Berghman, Luc, Hargis, Billy, Lu, Huaguang, 2011

Epidemic outbreaks, diagnostics, and control measures of the H5N1 highly pathogenic avian influenza in the Kingdom of Saudi Arabia, 2007-08
Avian diseases, Lu, Huaguang, Ismail, Mahmoud Moussa, Khan, Owais Ahmed, Al Hammad, Yousef, Rhman, Salah Shaban Abdel, Al-Blowi, Mohamed Hamad, 2010

Isolation and identification of highly pathogenic avian influenza virus subtype H5N1 in peafowl (Pavo cristatus)
Avian diseases, Ismail, Mahmoud Moussa, Khan, Owais Ahmed, Cattoli, Giovanni, Lu, Huaguang, 2010