Jessica A. Grembi, PhD

  • Assistant Professor of Pharmacology
306B Huck Life Sciences Building
University Park, PA 16802

Areas of Expertise

  • Gut microbiome
  • Childhood undernutrition
  • Small intestine microbial ecology
  • Environmental enteropathy
  • Global health

Education

  • PhD, Environmental Engineering, Stanford University
  • MS, Environmental Engineering, Penn State University
  • BS, Environmental Engineering, United States Military Academy at West Point

Publications

Pathways through which water, sanitation, hygiene, and nutrition interventions reduce antibiotic use in young children: a mediation analysis of a cluster-randomized trial.
eClinicalMedicine, Nguyen, A, Heitmann, G, Mertens, A, Ashraf, S, Rahman, M, Ali, S, Rahman, M, Arnold, B, Grembi, Jessica, Lin, A, Ercumen, A, Benjamin-Chung, J, 2025

Treatment heterogeneity of water, sanitation, hygiene, and nutrition interventions on child growth by environmental enteric dysfunction and pathogen status for young children in Bangladesh.
PLoS neglected tropical diseases, Butzin-Dozier, Z, Ji, Yunwen, Coyle, J, Malenica, I, Rogawski McQuade, E, Grembi, Jessica, Platts-Mills, J, Houpt, E, Graham, J, Ali, Shahjahan, Rahman, Md. Ziaur, Alauddin, M, Famida, S, Akther, S, Hossen, M, Mutsuddi, P, Shoab, A, Rahman, Mahbubur, Islam, Md. Ohedul, Miah, R, Taniuchi, M, Liu, Jie, Alauddin, S, Stewart, C, Luby, S, Colford, Jr, J, Hubbard, A, Mertens, A, Lin, Audrie, 2025

Water, sanitation, handwashing, and nutritional interventions can reduce child antibiotic use: evidence from Bangladesh and Kenya.
Nature Communications, Ercumen, A, Mertens, A, Butzin-Dozier, Z, Jung, D, Ali, Shahjahan, Achando, B, Rao, G, Hemlock, C, Pickering, A, Stewart, C, Tan, Sophia, Grembi, Jessica, Benjamin-Chung, J, Wolfe, M, Ho, G, Rahman, Md. Ziaur, Arnold, C, Dentz, H, Njenga, S, Meerkerk, T, Chen, B, Nadimpalli, M, Islam, Md. Ohedul, Hubbard, A, Null, C, Unicomb, L, Rahman, Mahbubur, Colford, Jr, J, Luby, S, Arnold, Benjamin, Lin, Audrie, 2025

Associations between weather extremes and faecal contamination along pathogen transmission pathways in rural Bangladeshi households: a prospective observational study.
The Lancet Planetary Health, Niven, C, Islam, Mahfuza, Nguyen, A, Grembi, Jessica, Mertens, A, Pickering, A, Kwong, L, Alam, M, Sen, D, Islam, S, Rahman, Mahbubur, Unicomb, L, Hubbard, A, Luby, S, Colford, Jr, J, Arnold, Benjamin, Benjamin-Chung, J, Ercumen, A, 2025

Influence of hydrometeorological risk factors on child diarrhea and enteropathogens in rural Bangladesh.
PLoS Neglected Tropical Diseases, Grembi, Jessica, Nguyen, A, Riviere, M, Heitmann, G, Patil, A, Athni, T, Djajadi, S, Ercumen, A, Lin, A, Crider, Y, Mertens, A, Karim, M, Islam, M, Miah, R, Famida, S, Hossen, M, Mutsuddi, P, Ali, S, Rahman, M, Hussain, Z, Shoab, A, Haque, R, Rahman, M, Unicomb, L, Luby, S, Arnold, B, Bennett, A, Benjamin-Chung, J, 2024

Influence of Temperature and Precipitation on the Effectiveness of Water, Sanitation, and Handwashing Interventions against Childhood Diarrheal Disease in Rural Bangladesh: A Reanalysis of the WASH Benefits Bangladesh Trial.
Environmental Health Perspectives, Nguyen, A, Grembi, Jessica, Riviere, M, Barratt Heitmann, G, Hutson, W, Athni, T, Patil, A, Ercumen, A, Lin, Audrie, Crider, Y, Mertens, A, Unicomb, L, Rahman, Mahbubur, Luby, S, Arnold, Benjamin, Benjamin-Chung, J, 2024

Is detection of enteropathogens and human or animal faecal markers in the environment associated with subsequent child enteric infections and growth: an individual participant data meta-analysis.
The Lancet Global Health, Mertens, A, Arnold, Benjamin, Benjamin-Chung, J, Boehm, A, Brown, J, Capone, D, Clasen, T, Fuhrmeister, E, Grembi, Jessica, Holcomb, D, Knee, J, Kwong, L, Lin, Audrie, Luby, S, Nala, R, Nelson, K, Njenga, S, Null, C, Pickering, A, Rahman, Mahbubur, Reese, H, Steinbaum, L, Stewart, J, Thilakaratne, R, Cumming, O, Colford, Jr, J, Ercumen, A, 2024

Human metabolome variation along the upper intestinal tract.
Nature Metabolism, Folz, J, Culver, R, Morales, J, Grembi, Jessica, Triadafilopoulos, G, Relman, D, Huang, K, Shalon, D, Fiehn, O, 2023

High-throughput low-cost nl-qPCR for enteropathogen detection: A proof-of-concept among hospitalized patients in Bangladesh.
PLoS One, Flaherty, K, Grembi, Jessica, Ramachandran, V, Haque, F, Khatun, S, Rahman, Mahmudu, Maples, S, Becker, T, Spormann, A, Schoolnik, G, Hryckowian, A, Nelson, Eric, 2021

Author Correction: Gut microbiota plasticity is correlated with sustained weight loss on a low-carb or low-fat dietary intervention (Scientific Reports, (2020), 10, 1, (1405), 10.1038/s41598-020-58000-y)
Scientific Reports, Grembi, Jessica A., Nguyen, Lan H., Haggerty, Thomas D., Gardner, Christopher D., Holmes, Susan P., Parsonnet, Julie, 2020

Gold Standard Cholera Diagnostics Are Tarnished by Lytic Bacteriophage and Antibiotics.
Journal of Clinical Microbiology, Nelson, Eric, Grembi, Jessica, Chao, D, Andrews, J, Alexandrova, L, Rodriguez, P, Ramachandran, V, Sayeed, M, Wamala, J, Debes, A, Sack, D, Hryckowian, A, Haque, F, Khatun, S, Rahman, M, Chien, A, Spormann, A, Schoolnik, G, 2020

High-Throughput Multiparallel Enteropathogen Detection via Nano-Liter qPCR.
Frontiers in cellular and infection microbiology, Grembi, Jessica, Mayer-Blackwell, K, Luby, S, Spormann, A, 2020

Shared bacterial communities between soil, stored drinking water, and hands in rural Bangladeshi households.
Water research X, Fuhrmeister, E, Ercumen, A, Grembi, Jessica, Islam, Mahfuza, Pickering, A, Nelson, Kara, 2020

Gut microbiota plasticity is correlated with sustained weight loss on a low-carb or low-fat dietary intervention.
Scientific reports, Grembi, Jessica, Nguyen, L, Haggerty, T, Gardner, C, Holmes, S, Parsonnet, J, 2020

Identification of Widespread Antibiotic Exposure in Patients With Cholera Correlates With Clinically Relevant Microbiota Changes.
Journal of Infectious Diseases, Alexandrova, L, Haque, F, Rodriguez, P, Marrazzo, A, Grembi, Jessica, Ramachandran, V, Hryckowian, A, Adams, C, Siddique MSA, None, Khan, A, Qadri, F, Andrews, J, Rahman, Mahmudur, Spormann, A, Schoolnik, G, Chien, A, Nelson, Eric, 2019