Joshua Kellogg

Joshua Kellogg

  • Assistant Professor
325 Huck Life Sciences Building
University Park, PA 16802

Areas of Expertise

  • Metabolomics
  • Natural Product Chemistry
  • Bioinformatics
  • Antimicrobial Drug Discovery
  • Ethnobotany and Indigenous Knowledge
  • Plant-associated Microbiomes
  • Botanical Dietary Supplements
  • Toxicology

The Kellogg Lab promotes a transdisciplinary approach to research, integrating analytical metabolomics, chemical biology, natural products chemistry, molecular biology, and ethnobotany to characterize bioactive natural products (metabolites) that interface with therapeutic targets to modulate human, plant, and animal health. We pursue ethnobotanical collaborations to discover new plant chemistry, and study botanical and environmental microbiomes and fungi for antimicrobial metabolites. Our lab uses a concerted approach, combining field screening, analytical metabolomics and bioinformatics with advanced analytical techniques, multi-platform chromatographic separations, isolation of lead compounds, and detailed structural and biological analysis to characterize active constituents as well as elucidate the mechanistic pathways of action. We also work to develop new bioanalytical and computational tools to expand the analytical capabilities of metabolomic analyses in chemistry, infectious disease biology, and ecology. Lead projects currently underway include examination of the phyllosphere for antimicrobial compounds; volatile metabolomics to elucidate bacterial-fungal interactions in the soil environment; and gut homeostasis and microbiome metabolism of dietary plants.

Publications

Quantification for non-targeted LC/MS screening without standard substances
Scientific reports, Liigand, Jaanus, Wang, Tingting, Kellogg, Joshua, Smedsgaard, Jørn, Cech, Nadja, Kruve, Anneli, 2020

The Chemistry of Kratom [ Mitragyna speciosa]
Journal of Natural Products, Flores-Bocanegra, Laura, Raja, Huzefa A., Graf, Tyler N., Augustinović, Mario, Wallace, E. Diane, Hematian, Shabnam, Kellogg, Joshua J., Todd, Daniel A., Cech, Nadja B., Oberlies, Nicholas H., 2020

Identification of adulteration in botanical samples with untargeted metabolomics
Analytical and Bioanalytical Chemistry, Wallace, E. Diane, Todd, Daniel A., Harnly, James M., Cech, Nadja B., Kellogg, Joshua J., 2020

Metabolomics, an essential tool in exploring and harnessing microbial chemical ecology
Phytobiomes Journal, Kellogg, Joshua, Kang, Seogchan, 2020

Chemical evaluation of the effects of storage conditions on the botanical goldenseal using marker-based and metabolomics approaches
Yale Journal of Biology and Medicine, Khin, Manead, Cech, Nadja B., Kellogg, Joshua J., Caesar, Lindsay K., 2020

Composite score analysis for unsupervised comparison and network visualization of metabolomics data
Analytica Chimica Acta, Kellogg, Joshua J., Kvalheim, Olav M., Cech, Nadja B., 2020

Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures
Journal of Natural Products, Caesar, Lindsay K., Kellogg, Joshua J., Kvalheim, Olav M., Cech, Nadja B., 2019

A random subset implementation of weighted quantile sum (WQSRS) regression for analysis of high-dimensional mixtures
Communications in Statistics: Simulation and Computation, Curtin, Paul, Kellogg, Joshua, Cech, Nadja, Gennings, Chris, 2019

Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics
Food and Chemical Toxicology, Wallace, Emily D., Oberlies, Nicholas H., Cech, Nadja B., Kellogg, Joshua J., 2018

Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei
Planta Medica, Caesar, Lindsay K., Kellogg, Joshua J., Kvalheim, Olav M., Cech, Richard A., Cech, Nadja B., 2018

Identification of intestinal UDP-Glucuronosyltransferase inhibitors in green tea (Camellia sinensis) using a biochemometric approach
Drug Metabolism and Disposition, Tian, Dan Dan, Kellogg, Joshua J., Okut, Neşe, Oberlies, Nicholas H., Cech, Nadja B., Shen, Danny D., McCune, Jeannine S., Paine, Mary F., 2018

Biochemometrics to Identify Synergists and Additives from Botanical Medicines
Journal of Natural Products, Britton, Emily R., Kellogg, Joshua J., Kvalheim, Olav M., Cech, Nadja B., 2018

Conventional and accelerated-solvent extractions of green tea (camellia sinensis) for metabolomics-based chemometrics
Journal of Pharmaceutical and Biomedical Analysis, Kellogg, Joshua J., Wallace, Emily D., Graf, Tyler N., Oberlies, Nicholas H., Cech, Nadja B., 2017

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations
Journal of Natural Products, Kellogg, Joshua J., Graf, Tyler N., Paine, Mary F., McCune, Jeannine S., Kvalheim, Olav M., Oberlies, Nicholas H., Cech, Nadja B., 2017

Antimicrobial fungal endophytes from the botanical medicine goldenseal (Hydrastis canadensis)
Phytochemistry Letters, Egan, Joseph M., Kaur, Amninder, Raja, Huzefa A., Kellogg, Joshua J., Oberlies, Nicholas H., Cech, Nadja B., 2016

Biochemometrics for Natural Products Research
Journal of Natural Products, Kellogg, Joshua J., Todd, Daniel A., Egan, Joseph M., Raja, Huzefa A., Oberlies, Nicholas H., Kvalheim, Olav M., Cech, Nadja B., 2016

Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes
Journal of Functional Foods, Kellogg, Joshua, Esposito, Debora, Grace, Mary H., Komarnytsky, Slavko, Lila, Mary Ann, 2015

Phlorotannins from alaskan seaweed inhibit carbolytic enzyme activity
Marine Drugs, Kellogg, Joshua, Grace, Mary H., Lila, Mary Ann, 2014

Chemical and in vitro assessment of Alaskan coastal vegetation antioxidant capacity
Journal of agricultural and food chemistry, Kellogg, Joshua, Lila, Mary Ann, 2013

Prospects for commercialisation of an Alaska native wild resource as a commodity crop
Journal of Entrepreneurship, Kellogg, Joshua, Higgs, Clyde, Lila, Mary Ann, 2011