Joshua Kellogg

Joshua Kellogg

  • Assistant Professor
325 Huck Life Sciences Building
University Park, PA 16802

Areas of Expertise

  • Metabolomics
  • Natural Product Chemistry
  • Bioinformatics
  • Antimicrobial Drug Discovery
  • Ethnobotany and Indigenous Knowledge
  • Plant-associated Microbiomes
  • Botanical Dietary Supplements
  • Toxicology

The Kellogg Lab promotes a transdisciplinary approach to research, integrating analytical metabolomics, chemical biology, natural products chemistry, molecular biology, and ethnobotany to characterize bioactive natural products (metabolites) that interface with therapeutic targets to modulate human, plant, and animal health. We pursue ethnobotanical collaborations to discover new plant chemistry, and study botanical and environmental microbiomes and fungi for antimicrobial metabolites. Our lab uses a concerted approach, combining field screening, analytical metabolomics and bioinformatics with advanced analytical techniques, multi-platform chromatographic separations, isolation of lead compounds, and detailed structural and biological analysis to characterize active constituents as well as elucidate the mechanistic pathways of action. We also work to develop new bioanalytical and computational tools to expand the analytical capabilities of metabolomic analyses in chemistry, infectious disease biology, and ecology. Lead projects currently underway include examination of the phyllosphere for antimicrobial compounds; volatile metabolomics to elucidate bacterial-fungal interactions in the soil environment; and gut homeostasis and microbiome metabolism of dietary plants.


Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools
Food and Chemical Toxicology, Waidyanatha, Suramya, Collins, Bradley J., Cristy, Tim, Embry, Michelle, Gafner, Stefan, Johnson, Holly, Kellogg, Josh, Krzykwa, Julie, Li, Siheng, Mitchell, Constance A., Mutlu, Esra, Pickett, Sarah, You, Hong, Van Breemen, Richard, Baker, Timothy R., 2024

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)
Molecules, Gao, Ying, Swiggart, Ethan, Wolkiewicz, Kaela, Liyanapathiranage, Prabha, Baysal-Gurel, Fulya, Avin, Farhat A., Lopez, Eleanor F.P., Jordan, Rebecca T., Kellogg, Joshua, Burkhart, Eric P., 2024

A methoxylated flavone from Artemisia afra kills Mycobacterium tuberculosis
BioRXiv, Kellogg, Josh, Alonso, Maria, Jordan, R, Xiao, Junpei, Cafiero, Juan, Bush, Trevor, Towler, Melissa, Weathers, Pamela, Shell, Scarlet, 2023

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)
Journal of Functional Foods, Chen, Xiaoling, Patterson, Andrew D., Perdew, Gary H., Murray, Iain A., Kellogg, Joshua J., 2023

Interaction Metabolomics to Discover Synergists in Natural Product Mixtures
Journal of Natural Products, Vidar, Warren S., Baumeister, Tim U.H., Caesar, Lindsay K., Kellogg, Joshua J., Todd, Daniel A., Linington, Roger G., M. Kvalheim, Olav, Cech, Nadja B., 2023

Secondary Terpenes in Cannabis sativa L.: Synthesis and Synergy
Biomedicines, Chacon, Francisco, Raup-Konsavage, Wesley M., Vrana, Kent E., Kellogg, Joshua, 2022

Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials
Frontiers in Nutrition, Abraham, Evelyn J., Kellogg, Joshua J., 2021

Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail
Clinical Pharmacology and Therapeutics, Nguyen, James T., Tian, Dan Dan, Tanna, Rakshit S., Hadi, Deena L., Bansal, Sumit, Calamia, Justina C., Arian, Christopher M., Shireman, Laura M., Molnár, Bálint, Horváth, Miklós, Kellogg, Joshua J., Layton, Matthew E., White, John R., Cech, Nadja B., Boyce, Richard D., Unadkat, Jashvant D., Thummel, Kenneth E., Paine, Mary F., 2021

Interlaboratory Comparison of Untargeted Mass Spectrometry Data Uncovers Underlying Causes for Variability
Journal of Natural Products, Clark, Trevor N., Houriet, Joëlle, Vidar, Warren S., Kellogg, Joshua J., Todd, Daniel A., Cech, Nadja B., Linington, Roger G., 2021

Quantification for non-targeted LC/MS screening without standard substances
Scientific Reports, Liigand, Jaanus, Wang, Tingting, Kellogg, Joshua, Smedsgaard, Jørn, Cech, Nadja, Kruve, Anneli, 2020

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
Scientific Reports, Todd, D. A., Kellogg, J. J., Wallace, E. D., Khin, M., Flores-Bocanegra, L., Tanna, R. S., McIntosh, S., Raja, H. A., Graf, T. N., Hemby, S. E., Paine, M. F., Oberlies, N. H., Cech, N. B., 2020

Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail
Clinical Pharmacology & Therapeutics, Nguyen, James, Tian, Dan-Dan, Tanna, Rakshit, Hadi, Deena, Bansal, Sumit, Calamia, Justina, Arian, Christopher, Shireman, None, Molnar, Balint, Horvath, Miklos, Kellogg, Josh, Layton, Matthew, White, John, Cech, Nadja, Boyce, Richard, Unadkat, Jashvant, Thummel, Kenneth, Paine, Mary, 2020

The Chemistry of Kratom [ Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids
Journal of Natural Products, Flores-Bocanegra, Laura, Raja, Huzefa A., Graf, Tyler N., Augustinović, Mario, Wallace, E. Diane, Hematian, Shabnam, Kellogg, Joshua J., Todd, Daniel A., Cech, Nadja B., Oberlies, Nicholas H., 2020

Identification of adulteration in botanical samples with untargeted metabolomics
Fresenius Zeitschrift fur Analytische Chemie, Wallace, E. Diane, Todd, Daniel A., Harnly, James M., Cech, Nadja B., Kellogg, Joshua J., 2020

Chemical evaluation of the effects of storage conditions on the botanical goldenseal using marker-based and metabolomics approaches
Yale Journal of Biology and Medicine, Khin, Manead, Cech, Nadja B., Kellogg, Joshua J., Caesar, Lindsay K., 2020

Composite score analysis for unsupervised comparison and network visualization of metabolomics data
Analytica Chimica Acta, Kellogg, Joshua J., Kvalheim, Olav M., Cech, Nadja B., 2020

Metabolomics, an essential tool in exploring and harnessing microbial chemical ecology
Phytobiomes Journal, Kellogg, Joshua, Kang, Seogchan, 2020

Selection and characterization of botanical natural products for research studies: A NaPDI center recommended approach
Natural Product Reports, Kellogg, Joshua J., Paine, Mary F., McCune, Jeannine S., Oberlies, Nicholas H., Cech, Nadja B., 2019

Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures
Journal of Natural Products, Caesar, Lindsay K., Kellogg, Joshua J., Kvalheim, Olav M., Cech, Nadja B., 2019

A random subset implementation of weighted quantile sum (WQSRS) regression for analysis of high-dimensional mixtures
Communications in Statistics Part B: Simulation and Computation, Curtin, Paul, Kellogg, Joshua, Cech, Nadja, Gennings, Chris, 2019

Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics
Food and Chemical Toxicology, Wallace, Emily D., Oberlies, Nicholas H., Cech, Nadja B., Kellogg, Joshua J., 2018

Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei
Planta Medica, Caesar, Lindsay K., Kellogg, Joshua J., Kvalheim, Olav M., Cech, Richard A., Cech, Nadja B., 2018

Identification of intestinal UDP-Glucuronosyltransferase inhibitors in green tea (Camellia sinensis) using a biochemometric approach: Application to raloxifene as a test drug via in vitro to in vivo extrapolation
Drug Metabolism and Disposition, Tian, Dan Dan, Kellogg, Joshua J., Okut, Neşe, Oberlies, Nicholas H., Cech, Nadja B., Shen, Danny D., McCune, Jeannine S., Paine, Mary F., 2018

Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)
Journal of Natural Products, Britton, Emily R., Kellogg, Joshua J., Kvalheim, Olav M., Cech, Nadja B., 2018

Conventional and accelerated-solvent extractions of green tea (camellia sinensis) for metabolomics-based chemometrics
Journal of Pharmaceutical and Biomedical Analysis, Kellogg, Joshua J., Wallace, Emily D., Graf, Tyler N., Oberlies, Nicholas H., Cech, Nadja B., 2017

The Americas, Kellogg, Joshua, Schmidt, B, Graf, B, Jofré‐Jimenez, C, Aguayo‐Cumplido, H, Calfio, C, Rojo, None, Cubillos‐Roble, K, Troncoso‐Fonseca, A, Delatorre‐Herrera, J, 2017

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study
Journal of Natural Products, Kellogg, Joshua J., Graf, Tyler N., Paine, Mary F., McCune, Jeannine S., Kvalheim, Olav M., Oberlies, Nicholas H., Cech, Nadja B., 2017

Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon
Phytochemistry Reviews, Kellogg, Joshua J., Raja, Huzefa A., 2017

Antimicrobial fungal endophytes from the botanical medicine goldenseal (Hydrastis canadensis)
Phytochemistry Letters, Egan, Joseph M., Kaur, Amninder, Raja, Huzefa A., Kellogg, Joshua J., Oberlies, Nicholas H., Cech, Nadja B., 2016

Engaging American Indian/Alaska Native (AI/AN) Students with Participatory Bioexploration Assays
NACTA Journal, Kellogg, Joshua, Croom, Dan, Plundrich, Nathalie, Taylor, Rebecca, Graf, Brittany, Raskin, Ilya, Lila, Mary Ann, 2016

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds
Journal of Natural Products, Kellogg, Joshua J., Todd, Daniel A., Egan, Joseph M., Raja, Huzefa A., Oberlies, Nicholas H., Kvalheim, Olav M., Cech, Nadja B., 2016

Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes
Journal of Functional Foods, Kellogg, Joshua, Esposito, Debora, Grace, Mary H., Komarnytsky, Slavko, Lila, Mary Ann, 2015

Phlorotannins from alaskan seaweed inhibit carbolytic enzyme activity
Marine Drugs, Kellogg, Joshua, Grace, Mary H., Lila, Mary Ann, 2014

Stressed for success: How the berry's wild origins result in multifaceted health protections, Lila, M. A., Kellogg, J., Grace, M. H., Yousef, G. G., Kraft, T. B., Rogers, R. B., 2014