Jeffrey M. Peters, PhD
- Distinguished Professor of Molecular Toxicology & Carcinogenesis
- Deputy Director, The Penn State Cancer Institute
University Park, PA 16802
- Email jmp21@psu.edu
- Office 814-863-1387
Areas of Expertise
- Molecular toxicology and carcinogenesis
- Nuclear receptors
- Peroxisome proliferator-activated receptors
- Cancer
- Lipid metabolism
Websites
Education
- Postdoctoral fellowship, National Cancer Institute, Bethesda, MD
- Postdoctoral fellowship, Institute of Toxicology and Environmental Health, University of California, Davis, CA
- PhD, Nutrition Science, University of California, Davis, CA
- BS, Dietetics, University of California, Davis, CA
Graduate Programs
- Molecular Cellular Integrative Biosciences (MCIBS)
- Biochemistry, Microbiology and Molecular Biology
- Pathobiology
Research
Our laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology and carcinogenesis. PPARs are members of the nuclear receptor superfamily and are critical modulators of environmental and dietary stimulii. For example fatty acids and metabolic derivatives of fatty acids derived primarily from dietary sources are known ligands that can activate PPARs. Moreover, environmental chemicals can also activate PPARs, such as perfluorinated chemicals and phthalate monesters that are currently a major health concern. Acting as regulatory transcription factors, the PPARs modulate gene expression of target genes containing peroxisome proliferator responsive elements in response to ligand activation. Numerous genes that modulate lipid metabolism are regulated by PPARα, PPARβ/δ and PPARγ ligands/activators, and are clinically relevant for a number of diseases including diabetes, obesity, atherosclerosis and cancer. In addition to transcriptional regulation, PPARs can also epigenetically regulate transcription by interacting with other proteins including NF-κB. Our laboratory uses “knockout", transgenic mouse models, and high affinity agonists and antagonists to delineate the roles of PPARs, with a particular interest in epithelial and liver cancer. Through our studies, we are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. We are particularly interested in delineating how natural compounds found in dietary constituents can activate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy. Our studies will likely lead to the identification of specific macronutrients that will effectively activate PPARs so that dietary formulations of agricultural products can be developed that will improve human and animal health and prevent serious diseases.
Publications
Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice
Metabolites, Zhu, Xiaoyang, Liu, Qing, Patterson, Andrew D., Sharma, Arun K., Amin, Shantu G., Cohen, Samuel M., Gonzalez, Frank J., Peters, Jeffrey M., 2023
2021-2022 Toxicological Sciences paper of the year
Toxicological Sciences, Guo, Lei, Peters, Jeffrey, 2023
Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells
Archives of Biochemistry and Biophysics, Hirao-Suzuki, Masayo, Takayuki, Koga, Takiguchi, Masufumi, Peters, Jeffrey M., Takeda, Shuso, 2022
The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice
Toxicology, Su, S, Billy, Laura, Chang, Sue, Gonzalez, Frank, Patterson, Andrew D., Peters, Jeffrey, 2022
Targeting peroxisome proliferator-activated receptor-β/δ (pparβ/δ) for the treatment or prevention of alcoholic liver disease
Biological and Pharmaceutical Bulletin, Koga, Takayuki, Peters, Jeffrey M., 2021
Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics
Annual Review of Analytical Chemistry, Collins, Stephanie, Koo, Imhoi, Peters, Jeffrey, Smith, Philip B., Patterson, Andrew D., 2021
Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice
Toxicological Sciences, Foreman, Jennifer E., Koga, Takayuki, Kosyk, Oksana, Kang, Boo Hyon, Zhu, Xiaoyang, Cohen, Samuel M., Billy, Laura J., Sharma, Arun K., Amin, Shantu, Gonzalez, Frank J., Rusyn, Ivan, Peters, Jeffrey M., 2021
Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice
Toxicological Sciences, Foreman, Jennifer E., Koga, Takayuki, Kosyk, Oksana, Kang, Boo Hyon, Zhu, Xiaoyang, Cohen, Samuel M., Billy, Laura J., Sharma, Arun K., Amin, Shantu, Gonzalez, Frank J., Rusyn, Ivan, Peters, Jeffrey M., 2021
Moving forward with ToxSci
Toxicological Sciences, Peters, Jeffrey M., 2020
Change is Good: What is New for ToxSci?
Toxicological Sciences, Peters, Jeffrey M., 2020
Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice
Toxicology, Zhang, Limin, Rimal, Bipin, Nichols, Robert, Tian, Yuan, Smith, Philip B., Hatzakis, Emmanuel, Chang, Shu-Ching, Butenhoff, John, Peters, Jeffrey, Patterson, Andrew D., 2020
Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer
Molecular Carcinogenesis, Peters, Jeffrey M., Kim, Dae J., Bility, Moses T., Borland, Michael G., Zhu, Bokai, Gonzalez, Frank J., 2019
Continuing a Legacy: Adapting to Ensure the Bright Future of ToxSci
Toxicological Sciences, Peters, Jeffrey M., 2019
Interplay Between the Host, the Human Microbiome, and Drug Metabolism
Human Genomics, Nichols, Robert, Peters, Jeffrey, Patterson, Andrew D., 2019
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis
npj Precision Oncology, Peters, Jeffrey, Walter, Vonn, Patterson, Andrew David, Gonzalez, Frank, 2019
The Evolution of Carcinogenesis
Toxicological Sciences, Peters, Jeffrey M., Gonzalez, Frank J., 2018
Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells
Toxicology, Borland, Michael, Kehres, Ellen, Lee, C, Wagner, Ashley, Shannon, Brooke, Albrecht, Prajakta, Zhu, Bokai, Gonzalez, Frank, Peters, Jeffrey, 2018
Lipid metabolism and lipophagy in cancer
Biochemical and Biophysical Research Communications, Maan, Meenu, Peters, Jeffrey, Dutta, Mainak, Patterson, Andrew D., 2018
Molecular Regulation of Carcinogenesis: Friend and Foe
Toxicological Sciences, Patterson, Andrew D., Gonzalez, Frank, Perdew, Gary, Peters, Jeffrey, 2018
The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions
Archiv fur Toxikologie, Corton, J. Christopher, Peters, Jeffrey M., Klaunig, James E., 2018
Perfluorooctane sulfonate-induced hepatic steatosis in male sprague dawley rats is not attenuated by dietary choline supplementation
Toxicological Sciences, Bagley, Bradford D., Chang, Shu Ching, Ehresman, David J., Eveland, Alan, Zitzow, Jeremiah D., Parker, George A., Peters, Jeffrey M., Wallace, Kendall B., Butenhoff, John L., 2017
Four-week dietary supplementation with 10- and/or 15-fold basal choline caused decreased body weight in Sprague Dawley rats
Toxicology and Industrial Health, Bagley, Bradford D., Chang, Shu Ching, Ehresman, David J., Eveland, Alan, Parker, George A., Peters, Jeffrey M., Butenhoff, John L., 2017
PPARβ/δ and PPARγ inhibit melanoma tumorigenicity by modulating inflammation and apoptosis
Toxicological Sciences, Borland, Michael G., Yao, Pei Li, Kehres, Ellen M., Lee, Christina, Pritzlaff, Amanda M., Ola, Elizabeth, Wagner, Ashley L., Shannon, Brooke E., Albrecht, Prajakta P., Zhu, Bokai, Kang, Boo Hyon, Robertson, Gavin P., Gonzalez, Frank J., Peters, Jeffrey M., 2017
Flipping a citrate switch on liver cancer cells
Journal of Biological Chemistry, Peters, Jeffrey M., 2017
Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation
Molecular Carcinogenesis, Yao, Pei Li, Chen, Liping, Dobrzański, Tomasz P., Zhu, Bokai, Kang, Boo Hyon, Müller, Rolf, Gonzalez, Frank J., Peters, Jeffrey M., 2017
Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation
Journal of Visualized Experiments, Allen, Joselyn N., Dey, Adwitia, Nissly, Ruth, Fraser, James, Yu, Shan, Balandaram, Gayathri, Peters, Jeffrey M., Hankey-Giblin, Pamela A., 2017
Peroxisome proliferator-activated receptor-β/δ modulates mast cell phenotype
Immunology, Yao, Pei Li, Morales, Jose L., Gonzalez, Frank J., Peters, Jeffrey M., 2017
अलगाव, विशेषता, और मोटापे से संबंधित सूजन से प्रभावित ऊतकों से मैक्रोफेज की शुद्धि, Allen, Joselyn, Dey, Adwitia, Nissly, Ruth, Fraser, James, Yu, Shan, Balandaram, Gayathri, Peters, Jeffrey, Hankey-Giblin, Pamela, 2017
비만 관련 염증에 의해 영향을받는 조직에서 분리, 특성, 및대 식세포의 정제, Allen, Joselyn, Dey, Adwitia, Nissly, Ruth, Fraser, James, Yu, Shan, Balandaram, Gayathri, Peters, Jeffrey, Hankey-Giblin, Pamela, 2017
From the Editor’s Desk, Editor’s Highlights, Campen, Matthew, Flaws, Jodi, Johanson, Gunnar, Peters, Jeffrey, 2017
Omics Approaches to Probe Microbiota and Drug Metabolism Interactions
Chemical Research in Toxicology, Nichols, Robert G., Hume, Nicole E., Smith, Philip B., Peters, Jeffrey M., Patterson, Andrew D., 2016
Regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-β/δ modulation of SP1 promoter occupancy
Journal of Biological Chemistry, Koga, Takayuki, Yao, Pei Li, Goudarzi, Maryam, Murray, Iain A., Balandaram, Gayathri, Gonzalez, Frank J., Perdew, Gary H., Fornace, Albert J., Peters, Jeffrey M., 2016
Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice
Toxicological Sciences, Zhang, Limin, Krishnan, Prasad, Ehresman, David J., Smith, Philip B., Dutta, Mainak, Bagley, Bradford D., Chang, Shu Ching, Butenhoff, John L., Patterson, Andrew D., Peters, Jeffrey M., 2016
Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice
Toxicology, Balandaram, Gayathri, Kramer, Lance R., Kang, Boo Hyon, Murray, Iain A., Perdew, Gary H., Gonzalez, Frank J., Peters, Jeffrey M., 2016
The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Journal of Immunology, Yu, Shan, Allen, Joselyn N., Dey, Adwitia, Zhang, Limin, Balandaram, Gayathri, Kennett, Mary J., Xia, Mingcan, Xiong, Na, Peters, Jeffrey M., Patterson, Andrew, Hankey-Giblin, Pamela A., 2016
PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration
Aging, Choudhary, Mayur, Ding, Jin dong, Qi, Xiaoping, Boulton, Michael E., Yao, Pei Li, Peters, Jeffrey M., Malek, Goldis, 2016
Ron receptor tyrosine kinase plays a protective role in diet induced obesity and associated steatohepatitis, Allen, Joselyn, Zhang, Limin, Yu, Shan, Balandaram, Gayathri, Peters, Jeffrey, Patterson, A, Hankey, P, 2016
Examining role of peroxisome proliferator-activated receptor-?/? (PPAR?/?) in colon cancer
Presented at the Society of Toxicology Annual Meeting, Wang, X., Zhu, B., Gonzalez, F., Peters, Jeffrey, 2016
Ligand activation of PPAR?/? inhibits EMT in a human colon cancer cell line
Presented at the Society of Toxicology Annual Meeting, Consevage, K., Pramanik, K., Gonzalez, F., Peters, Jeffrey, 2016
A Nuclear Messenger Links Cannabinoid-1 (CB1) Signalling to Fatty Liver
Journal of Hepatology, Azar, Sandra, Drori, A, Knani, I, Udi, S, Hadar, R, Vemuri, KV, Makriyannis, A, Peters, JM, Tam, J, 2016
Peroxisome proliferator-activated receptor-?/? (PPAR?/?)-dependent inhibition of UVB-induced skin carcinogenesis: targeting p53 mutant cells
Presented at the Society of Toxicology Annual Meeting, Ralph, D., Pramanik, K., Gonzalez, F., Peters, Jeffrey, 2016
Establishing the Role of PPARβ/δ in Carcinogenesis
Trends in Endocrinology and Metabolism, Peters, Jeffrey M., Gonzalez, Frank J., Müller, Rolf, 2015
Peroxisome proliferator-activated receptor-D (PPARD) coordinates mouse spermatogenesis by modulating extracellular signal-regulated kinase (ERK)-dependent signaling
Journal of Biological Chemistry, Yao, Pei Li, Chen, Li Ping, Hess, Rex A., Müller, Rolf, Gonzalez, Frank J., Peters, Jeffrey M., 2015
M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression
Cell Reports, Park, Jonghanne, Lee, Sang Eun, Hur, Jin, Hong, Eun Byeol, Choi, Jae Il, Yang, Ji Min, Kim, Ju Young, Kim, Young Chan, Cho, Hyun Jai, Peters, Jeffrey M., Ryoo, Seung Bum, Kim, Young Tae, Kim, Hyo Soo, 2015
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms
Oncotarget, Yao, Pei Li, Chen, Li Ping, Dobrzanski, Tomasz P., Phillips, Dylan A., Zhu, Bokai, Kang, Boo Hyon, Gonzalez, Frank J., Peters, Jeffrey M., 2015
Ligand activation of peroxisome proliferator-activated receptor-?/? (PPAR?/?) inhibits UVB-induced skin cancer
Presented at the Society of Toxicology Annual Meeting, Krishnan, P., Pramanik, K., Gonzalez, F., Peters, Jeffrey, 2015
Ligand activation of PPAR?/? attenuates inflammation in both primary and KC13-2 Kupffer cells
Presented at the Society of Toxicology Annual Meeting, Balandaram, G., Gonzalez, F., Peters, Jeffrey, 2015
Peroxisome proliferator-activated receptor-?/? (PPAR?/?) inhibits tumorigenesis by interfering with RAR?-mediated MMP2 activation and inducing cell differentiation in human testicular embryonal carcinoma cells
Presented at the Society of Toxicology Annual Meeting, Yao, P., Chen, L., Phillips, D., Zhu, B., Gonzalez, F., Peters, Jeffrey, 2015
PPAR?/? and PPAR? modulate UV-induced apoptosis and cytokine secretion in a human melanoma cell line
Presented at the Society of Toxicology Annual Meeting, Wagner, A., Gonzalez, F., Peters, Jeffrey, Borland, M., 2015
Targeting the peroxisome proliferator-activated receptor (PPAR): Implications for dry and wet age-related macular degeneration
Presented at the Association for Research in Vision and Ophthalmology Annual Meeting, Choudary, M., Johnson, L., Forrest, D., Qi, X., Boulton, M., Peters, Jeffrey, Malek, G., 2015
Hardware off-load memory garbage collection acceleration, Allen, Joseph, Matsa, Moshe, Maze, David, Peters, Jeffrey, 2015
Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention
Current Pharmacology Reports, Peters, Jeffrey, Yao, P, Gonzalez, F, 2015
Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid
Toxicology, Yao, Pei Li, Ehresman, David J., Rae, Jessica M.Caverly, Chang, Shu Ching, Frame, Steven R., Butenhoff, John L., Kennedy, Gerald L., Peters, Jeffrey M., 2014
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling
Oncogene, Zhu, B., Ferry, C. H., Blazanin, N., Bility, M. T., Khozoie, C., Kang, B. H., Glick, A. B., Gonzalez, F. J., Peters, J. M., 2014
Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity
Molecular Cancer Therapeutics, Yao, Pei Li, Morales, Jose L., Zhu, Bokai, Kang, Boo Hyon, Gonzalez, Frank J., Peters, Jeffrey M., 2014
Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis
Journal of Pharmacology and Experimental Therapeutics, Lahoti, Tejas S., Hughes, Jarod M., Kusnadi, Ann, John, Kaarthik, Zhu, Bokai, Murray, Iain A., Gowda, Krishne, Peters, Jeffrey M., Amin, Shantu G., Perdew, Gary H., 2014
Targeting estrogen receptor-β for the prevention of nonmelanoma skin cancer
Cancer Prevention Research, Yao, Pei Li, Gonzalez, Frank J., Peters, Jeffrey M., 2014
The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
Journal of Biological Chemistry, Zhu, Bokai, Ferry, Christina H., Markell, Lauren K., Blazanin, Nicholas, Glick, Adam B., Gonzalez, Frank J., Peters, Jeffrey M., 2014
Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes
Carcinogenesis, Borland, Michael G., Krishnan, Prasad, Lee, Christina, Albrecht, Prajakta P., Shan, Weiwei, Bility, Moses T., Marcus, Craig B., Lin, Jyh M., Amin, Shantu, Gonzalez, Frank J., Perdew, Gary H., Peters, Jeffrey M., 2014
Peroxisome Proliferator-activated Receptor-b/d (pparb/d) Regulates Spermatogenesis By Altering Cell-cycle Regulators In Mice
Andrology, Yao, Pei-li, Chen, Liping, Gonzalez, Frank, Peters, Jeffrey, 2014
Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study
Critical Reviews in Toxicology, Corton, J. Christopher, Cunningham, Michael L., Hummer, B. Timothy, Lau, Christopher, Meek, Bette, Peters, Jeffrey M., Popp, James A., Rhomberg, Lorenz, Seed, Jennifer, Klaunig, James E., 2014
Compromised adaptive upregulation of mitochondrial metabolism and accumulation of hepatic lipids associate with alcoholic liver damage in Ppar?–/– mice
Presented at the Society of Toxicology Annual Meeting, Li, H.-H., Tyburski, J., Mak, T., Peters, Jeffrey, Florance, Jr., A., 2014
Ethanol-induced hepatic expression of cytochrome P450 (Cyp) 2b10 is dependent on PPAR?/?
Presented at the Society of Toxicology Annual Meeting, Koga, T., Balandaram, G., Goudarzi, M., Fornace, A., Gonzalez, F., Peters, Jeffrey, 2014
Investigation of the role of peroxisome proliferator-activated receptor-?/? (PPAR?/?) in hepatitis C transgenic mice
Presented at the European Association for the Study of the Liver, Balandaram, G., Kramer, L., Gonzalez, F., Peters, Jeffrey, 2014
Ligand activation of peroxisome proliferator-activated receptor-?/? (PPAR?/?) attenuates liver tumorigenesis in HBV transgenic mice
Presented at the Society of Toxicology Annual Meeting, Balandaram, G., Kramer, L., Kang, B., Gonzlaez, F., Peters, Jeffrey, 2014
Ligand activation of peroxisome proliferator-activated receptor-?/? (PPAR?/?) inhibits TGF?1-induced epithelial-mesenchymal transition (EMT) in a human lung cancer cell line
Presented at the Society of Toxicology Annual Meeting, Pramanik, K., Pidathala, A., Zhu, B., Gonzlaez, F., Peters, Jeffrey, 2014
Ligand activation of PPAR?/? inhibits invasion and formation of three dimensional spheroids of the LNCaP prostate cancer cell line
Presented at the Society of Toxicology Annual Meeting, Krishnan, P., Peters, Jeffrey, 2014
Peroxisome proliferator-activated receptor-?/? (PPAR?/?) inhibits cell proliferation and MMP-2-mediated tumorigenesis in human testicular embryonal carcinoma cells
Presented at the Society of Toxicology Annual Meeting, Yao, P., Chen, L., Zhu, B., Gonzlaez, F., Peters, Jeffrey, 2014
Divergent inositol-requiring enzyme 1 rnase activities dictate the senescence response of mouse keratinocytes to oncogenic RAS and are linked to tumor progression, Blazanin, N, John, C, Zhu, B, Peters, Jeffrey, Glick, A, 2014
PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity
Toxicology, Goudarzi, Maryam, Koga, Takayuki, Khozoie, Combiz, Mac, Tytus D., Kang, Boo Hyon, Fornace, Albert J., Peters, Jeffrey M., 2013
Cholestasis induces reversible accumulation of periplakin in mouse liver
BMC Gastroenterology, Ito, Shinji, Satoh, Junko, Matsubara, Tsutomu, Shah, Yatrik M., Ahn, Sung hoon, Anderson, Cherie R., Shan, Weiwei, Peters, Jeffrey M., Gonzalez, Frank J., 2013
A species difference in the peroxisome proliferator-activated receptor α-dependent response to the developmental effects of perfluorooctanoic acid
Toxicological Sciences, Albrecht, Prajakta P., Torsell, Nicole E., Krishnan, Prasad, Ehresman, David J., Frame, Steven R., Chang, Shu Ching, Butenhoff, John L., Kennedy, Gerald L., Gonzalez, Frank J., Peters, Jeffrey M., 2013
THE ROLE OF CHOLINE DEPLETION IN PERFLUOROOCTANESULFONATE-INDUCED HEPATIC STEATOSIS
The FASEB Journal, Krishnan, Prasad, Patterson, A, Ehresman, David, Smith, P, Scavello, Margaretha, Chang, Shu-Ching, Butenhoff, John, Peters, Jeffrey, 2013
Metabolomics: An essential tool to understand the function of peroxisome proliferator-activated receptor alpha
Toxicologic Pathology, Montanez, J., Peters, Jeffrey M., Correll, J., Gonzalez, Frank J., Patterson, Andrew D., 2013
Inhibition of clonogenicity and xenograft tumor growth by activation and/or over-expression of peroxisome proliferator-activated receptor-$β$/$δ$ (PPAR$β$/$δ$)., Yao, Pei-Li, Borland, Michael, Krishnan, Prasad, Zhu, Bokai, Gonzalez, Frank, Peters, Jeffrey, 2013
Effect of ligand activation of PPAR?/? in Kupffer cells
Presented at the Society of Toxicology Annual Meeting, Balandaram, G., Gonzalez, F., Peters, Jeffrey, 2013
Hepatocarcinogenesis induced by a potent, high affinity human PPAR? agonist is diminished in PPAR?-humanized mice
Presented at the Society of Toxicology Annual Meeting, Foreman, J., Koga, T., Kosyk, O., Kramer, L., Gonzalez, F., Rusyn, I., Peters, Jeffrey, 2013
