Mary J. Kennett, DVM, Ph.D., Diplomate ACLAM

Professor Emeritus
Director, Animal Resource Program

101 Centralized Biological Lab
University Park, PA 16802

Email mjk26@psu.edu
Office 814-865-1495

Areas of Expertise

comparative medicine
animal models
infectious disease and biocontainment
rodent pathology
animal behavior
laboratory animal resource management
veterinary medicine

Education

Residency Training, Comparative Medicine, University of Missouri-Columbia
PhD, Pathobiology, University of Missouri-Columbia
MS, Biology, Walla Walla College
DVM, Washington State University
BS, Veterinary Science, Washington State University

Graduate Programs

Pathobiology
Molecular Cellular Integrative Biosciences (MCIBS)

Research

My primary research interest is the pathogenesis of infectious disease; most specifically, virulence factors involved in initial colonization of the host and mucosal immune responses. Current efforts are directed toward pathology, and the identification and characterization of virulence factors of Bordetella bronchiseptica , and B. pertussis. We are studying the host immune response to Bordetella infections in transgenic and immunocompromised mice in order to better understand the pathogenesis of respiratory infections and the specific immune responses that are effective in clearance of bacteria from the upper and lower respiratory tract.

In addition, my interests include laboratory animal resource management, comparative medicine, animal behavior and well being, and the preventative and clinical veterinary care of research animals.

Publications

Effects of Human Electro-Muscular Incapacitation (HEMI) Devices on Cardiovascular Changes in Anesthetized Swine as Measured by Transesophageal Echocardiography (TEE)
Journal of Forensic Sciences, Werner, Jacob R., Murray, W. Bosseau, Kennett, Mary J., Jenkins, David M., Liszka, Edward, Hughes, Edward L., 2019

Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype
Proceedings of the National Academy of Sciences of the United States of America, Kerr, P, Cattadori, Isabella M., Liu, J, Sim, Derek G., Dodds, Jeff W., Brooks, Jason W., Kennett, Mary J., Holmes, Edward C., Read, Andrew F., 2017

Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors
Inflammatory Bowel Diseases, Saha, Piu, Chassaing, Benoit, Yeoh, Beng San, Viennois, Emilie, Xiao, Xia, Kennett, Mary J., Singh, Vishal, Vijay-Kumar, Matam, 2017

Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan
Growth Hormone and IGF Research, Kraemer, William J., Kennett, Mary J., Mastro, Andrea M., McCarter, Roger J., Rogers, Connie J., DuPont, William H., Flanagan, Shawn D., Turbitt, William J., Fragala, Maren S., Post, Emily M., Hymer, Wesley C., 2017

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Journal of Immunology, Yu, Shan, Allen, Joselyn N., Dey, Adwitia, Zhang, Limin, Balandaram, Gayathri, Kennett, Mary J., Xia, Mingcan, Xiong, Na, Peters, Jeffrey M., Patterson, Andrew, Hankey-Giblin, Pamela A., 2016

Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation
American Journal of Pathology, Yeoh, Beng San, Aguilera Olvera, Rodrigo, Singh, Vishal, Xiao, Xia, Kennett, Mary J., Joe, Bina, Lambert, Joshua D., Vijay-Kumar, Matam, 2016

Inhibition of interleukin-10 signaling induces microbiota-dependent chronic colitis in Apolipoprotein E deficient mice
Inflammatory Bowel Diseases, Singh, Vishal, Kumar, Manish, San Yeoh, Beng, Xiao, Xia, Saha, Piu, Kennett, Mary J., Vijay-Kumar, Matam, 2016

Growth in egg yolk enhances salmonella enteritidis colonization and virulence in a mouse model of human colitis
PLoS One, Moreau, M, Wijetunge, D, Bailey, M, Gongati, S, Goodfield, L, Hewage, E, Kennett, M, Fedorchuk, C, Ivanov, Y, Linder, J, Jayarao, Bhushan, Kariyawasam, S, 2016

Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells
American Journal of Physiology, Yeoh, Beng San, Saha, Piu, Singh, Vishal, Xiao, Xia, Ying, Yun, Vanamala, Jairam K., Kennett, Mary J., Harvatine, Kevin J., Joe, Bina, Vijay-Kumar, Matam, 2016

Type six secretion system of bordetella bronchiseptica and adaptive immune components limit intracellular survival during infection
PLoS One, Bendor, Liron, Weyrich, Laura S., Linz, Bodo, Rolin, Olivier Y., Taylor, Dawn L., Goodfield, Laura L., Smallridge, William E., Kennett, Mary J., Harvill, Eric T., 2015

Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia
Cancer Prevention Research, Finch, Emily R., Kudva, Avinash K., Quickel, Michael D., Goodfield, Laura L., Kennett, Mary J., Whelan, Jay, Paulson, Robert F., Sandeep Prabhu, K., 2015

Vitamin A-deficient hosts become nonsymptomatic reservoirs of Escherichia coli-like enteric infections
Infection and Immunity, McDaniel, K, Restori, Katherine, Dodds, Jeffery W., Kennett, M, Ross, A. Catharine, Cantornaa, Margherita T., Cantorna, M, 2015

Crucial role of macrophage selenoproteins in experimental colitis
Journal of Immunology, Kaushal, Naveen, Kudva, Avinash K., Patterson, Andrew D., Chiaro, Christopher, Kennett, Mary J., Desai, Dhimant, Amin, Shantu, Carlson, Bradley A., Cantorna, Margherita T., Prabhu, K. Sandeep, 2014

Selenium suppresses leukemia through the action of endogenous eicosanoids
Cancer Research, Gandhi, Ujjawal H., Kaushal, Naveen, Hegde, Shailaja, Finch, Emily R., Kudva, Avinash K., Kennett, Mary J., Jordan, Craig T., Paulson, Robert F., Prabhu, K. Sandeep, 2014

Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: Δ¹²-prostaglandin J₃
PLoS One, Kudva, Avinash K., Kaushal, Naveen, Mohinta, Sonia, Kennett, Mary J., August, Avery, Paulson, Robert F., Prabhu, K. Sandeep, 2013

The Effects of Continuous Application of the TASER X26 Waveform on Sus scrofa
Journal of Forensic Sciences, Jenkins, David M., Murray, W. Bosseau, Kennett, Mary J., Hughes, Edward L., Werner, Jacob R., 2013

Immunization with pneumococcal polysaccharide serotype 3 and lipopolysaccharide modulates lung and liver inflammation during a virulent Streptococcus pneumoniae infection in mice
Clinical and Diagnostic Laboratory Immunology, Restori, Katherine, Kennett, M, Ross, A. Catharine, 2013