Mary J. Kennett, DVM, Ph.D., Diplomate ACLAM

Mary J. Kennett, DVM, Ph.D., Diplomate ACLAM

  • Professor Emeritus
  • Director, Animal Resource Program
101 Centralized Biological Lab
University Park, PA 16802

Areas of Expertise

  • comparative medicine
  • animal models
  • infectious disease and biocontainment
  • rodent pathology
  • animal behavior
  • laboratory animal resource management
  • veterinary medicine

Education

  • Residency Training, Comparative Medicine, University of Missouri-Columbia
  • PhD, Pathobiology, University of Missouri-Columbia
  • MS, Biology, Walla Walla College
  • DVM, Washington State University
  • BS, Veterinary Science, Washington State University

Graduate Programs

Research

My primary research interest is the pathogenesis of infectious disease; most specifically, virulence factors involved in initial colonization of the host and mucosal immune responses. Current efforts are directed toward pathology, and the identification and characterization of virulence factors of Bordetella bronchiseptica , and B. pertussis. We are studying the host immune response to Bordetella infections in transgenic and immunocompromised mice in order to better understand the pathogenesis of respiratory infections and the specific immune responses that are effective in clearance of bacteria from the upper and lower respiratory tract.

In addition, my interests include laboratory animal resource management, comparative medicine, animal behavior and well being, and the preventative and clinical veterinary care of research animals.

Publications

Effects of Human Electro-Muscular Incapacitation (HEMI) Devices on Cardiovascular Changes in Anesthetized Swine as Measured by Transesophageal Echocardiography (TEE)
Journal of Forensic Sciences, Werner, Jacob R., Murray, W. Bosseau, Kennett, Mary J., Jenkins, David M., Liszka, Edward, Hughes, Edward L., 2019

Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype
Proceedings of the National Academy of Sciences of the United States of America, Kerr, Peter J., Cattadori, Isabella M., Liu, June, Sim, Derek G., Dodds, Jeff W., Brooks, Jason W., Kennett, Mary J., Holmes, Edward C., Read, Andrew F., 2017

Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors
Inflammatory Bowel Diseases, Saha, Piu, Chassaing, Benoit, Yeoh, Beng San, Viennois, Emilie, Xiao, Xia, Kennett, Mary J., Singh, Vishal, Vijay-Kumar, Matam, 2017

Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan
Growth Hormone and IGF Research, Kraemer, William J., Kennett, Mary J., Mastro, Andrea M., McCarter, Roger J., Rogers, Connie J., DuPont, William H., Flanagan, Shawn D., Turbitt, William J., Fragala, Maren S., Post, Emily M., Hymer, Wesley C., 2017

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Journal of Immunology, Yu, Shan, Allen, Joselyn N., Dey, Adwitia, Zhang, Limin, Balandaram, Gayathri, Kennett, Mary J., Xia, Mingcan, Xiong, Na, Peters, Jeffrey M., Patterson, Andrew, Hankey-Giblin, Pamela A., 2016

Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation
American Journal of Pathology, Yeoh, Beng San, Aguilera Olvera, Rodrigo, Singh, Vishal, Xiao, Xia, Kennett, Mary J., Joe, Bina, Lambert, Joshua D., Vijay-Kumar, Matam, 2016

Inhibition of interleukin-10 signaling induces microbiota-dependent chronic colitis in Apolipoprotein E deficient mice
Inflammatory Bowel Diseases, Singh, Vishal, Kumar, Manish, San Yeoh, Beng, Xiao, Xia, Saha, Piu, Kennett, Mary J., Vijay-Kumar, Matam, 2016

Growth in egg yolk enhances salmonella enteritidis colonization and virulence in a mouse model of human colitis
PLoS One, Moreau, Matthew R., Wijetunge, Dona Saumya S., Bailey, Megan L., Gongati, Sudharsan R., Goodfield, Laura L., Hewage, Eranda Mangala K.Kurundu, Kennett, Mary J., Fedorchuk, Christine, Ivanov, Yury V., Linder, Jessica E., Jayarao, Bhushan M., Kariyawasam, Subhashinie, 2016

Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells
American Journal of Physiology, Yeoh, Beng San, Saha, Piu, Singh, Vishal, Xiao, Xia, Ying, Yun, Vanamala, Jairam K., Kennett, Mary J., Harvatine, Kevin J., Joe, Bina, Vijay-Kumar, Matam, 2016

Type six secretion system of bordetella bronchiseptica and adaptive immune components limit intracellular survival during infection
PLoS One, Bendor, Liron, Weyrich, Laura S., Linz, Bodo, Rolin, Olivier Y., Taylor, Dawn L., Goodfield, Laura L., Smallridge, William E., Kennett, Mary J., Harvill, Eric T., 2015

Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia
Cancer Prevention Research, Finch, Emily R., Kudva, Avinash K., Quickel, Michael D., Goodfield, Laura L., Kennett, Mary J., Whelan, Jay, Paulson, Robert F., Sandeep Prabhu, K., 2015

Vitamin A-deficient hosts become nonsymptomatic reservoirs of Escherichia coli-like enteric infections
Infection and Immunity, McDaniel, Kaitlin L., Restori, Katherine H., Dodds, Jeffery W., Kennett, Mary J., Ross, A. Catharine, Cantornaa, Margherita T., 2015

Crucial role of macrophage selenoproteins in experimental colitis
Journal of Immunology, Kaushal, Naveen, Kudva, Avinash K., Patterson, Andrew D., Chiaro, Christopher, Kennett, Mary J., Desai, Dhimant, Amin, Shantu, Carlson, Bradley A., Cantorna, Margherita T., Prabhu, K. Sandeep, 2014

Selenium suppresses leukemia through the action of endogenous eicosanoids
Cancer Research, Gandhi, Ujjawal H., Kaushal, Naveen, Hegde, Shailaja, Finch, Emily R., Kudva, Avinash K., Kennett, Mary J., Jordan, Craig T., Paulson, Robert F., Prabhu, K. Sandeep, 2014

Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin
PLoS One, Kudva, Avinash K., Kaushal, Naveen, Mohinta, Sonia, Kennett, Mary J., August, Avery, Paulson, Robert F., Prabhu, K. Sandeep, 2013

The Effects of Continuous Application of the TASER X26 Waveform on Sus scrofa
Journal of Forensic Sciences, Jenkins, David M., Murray, W. Bosseau, Kennett, Mary J., Hughes, Edward L., Werner, Jacob R., 2013

(-)-epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice
Obesity, Grove, Kimberly A., Sae-Tan, Sudathip, Kennett, Mary J., Lambert, Joshua D., 2012

Comparison of the agar block and Lieber-DeCarli diets to study chronic alcohol consumption in an aging model of Fischer 344 female rats.
Journal of Pharmacological and Toxicological Methods, Sharda, Daniel R., Miller-Lee, Jennifer L., Kanski, Gregory M., Hunter, J. Craig, Lang, Charles H., Kennett, Mary J., Korzick, Donna H., 2012

A type VI secretion system encoding locus is required for bordetella bronchiseptica immunomodulation and persistence in vivo
PLoS One, Weyrich, Laura S., Rolin, Olivier Y., Muse, Sarah J., Park, Jihye, Spidale, Nicholas, Kennett, Mary J., Hester, Sara E., Chen, Chun, Dudley, Edward G., Harvill, Eric T., 2012

Human electromuscular incapacitation devices characterization
Journal of Strength and Conditioning Research, Werner, Jacob R., Jenkins, David M., Murray, W. Bosseau, Hughes, Edward L., Bienus, David A., Kennett, Mary J., 2012

Δ 12-prostaglandin J 3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Blood, Hegde, Shailaja, Kaushal, Naveen, Ravindra, Kodihalli C., Chiaro, Christopher, Hafer, Kelsey T., Gandhi, Ujjawal H., Thompson, Jerry T., Van Den Heuvel, John P., Kennett, Mary J., Hankey, Pamela, Paulson, Robert F., Prabhu, K. Sandeep, 2011

Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese
Journal of Applied Physiology, Thomas, Gwendolyn A., Kraemer, William J., Kennett, Mary J., Comstock, Brett A., Maresh, Carl M., Denegar, Craig R., Volek, Jeff S., Hymer, Wesley C., 2011

(-)-Epigallocatechin-3-gallate increases the expression of genes related to fat oxidation in the skeletal muscle of high fat-fed mice
Food and Function, Sae-Tan, Sudathip, Grove, Kimberly A., Kennett, Mary J., Lambert, Joshua D., 2011

IACUC issues related to animal models of aging
ILAR Journal, Heiderstadt, Kathleen M., Kennett, Mary J., 2011

Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection-or vaccination-induced immunity against bordetella pertussis
Infection and Immunity, Zhang, Xuqing, Hester, Sara E., Kennett, Mary J., Karanikas, Alexia T., Bendor, Liron, Place, David E., Harvill, Eric T., 2011