Mary J. Kennett, DVM, Ph.D., Diplomate ACLAM

Mary J. Kennett, DVM, Ph.D., Diplomate ACLAM

  • Professor Emeritus
  • Director, Animal Resource Program
101 Centralized Biological Lab
University Park, PA 16802

Areas of Expertise

  • comparative medicine
  • animal models
  • infectious disease and biocontainment
  • rodent pathology
  • animal behavior
  • laboratory animal resource management
  • veterinary medicine

Education

  • Residency Training, Comparative Medicine, University of Missouri-Columbia
  • PhD, Pathobiology, University of Missouri-Columbia
  • MS, Biology, Walla Walla College
  • DVM, Washington State University
  • BS, Veterinary Science, Washington State University

Graduate Programs

Research

My primary research interest is the pathogenesis of infectious disease; most specifically, virulence factors involved in initial colonization of the host and mucosal immune responses. Current efforts are directed toward pathology, and the identification and characterization of virulence factors of Bordetella bronchiseptica , and B. pertussis. We are studying the host immune response to Bordetella infections in transgenic and immunocompromised mice in order to better understand the pathogenesis of respiratory infections and the specific immune responses that are effective in clearance of bacteria from the upper and lower respiratory tract.

In addition, my interests include laboratory animal resource management, comparative medicine, animal behavior and well being, and the preventative and clinical veterinary care of research animals.

Publications

Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling.
Metabolites, Allen, J, Dey, A, Cai, Jingjing, Zhang, J, Tian, Y, Kennett, Mary, Ma, Yanyuan, Liang, T, Patterson, Andrew, Hankey, Pamela, 2020

Effects of Human Electro-Muscular Incapacitation (HEMI) Devices on Cardiovascular Changes in Anesthetized Swine as Measured by Transesophageal Echocardiography (TEE)
Journal of Forensic Sciences, Werner, Jacob Robert, Murray, W. Bosseau, Kennett, Mary J., Jenkins, Jr., David Marion, Liszka, Edward, Hughes, Edward L., 2019

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer
Cell, Singh, Vishal, Yeoh, Beng San, Chassaing, Benoit, Xiao, Xia, Saha, Piu, Aguilera Olvera, Rodrigo, Lapek, John D., Zhang, Limin, Wang, Wei-bei, Hao, Sijie, Flythe, Michael D., Gonzalez, David J., Cani, Patrice D., Conejo-Garcia, Jose R., Xiong, Na, Kennett, Mary J., Joe, Bina, Patterson, Andrew David, Gewirtz, Andrew T., Vijay-Kumar, Matam, 2018

Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model
Journal of Proteome Research, Allen, Joselyn, Zhang, Jingtao, Quickel, Michael D., Kennett, Mary J., Patterson, Andrew David, Giblin, Pamela Hankey, 2018

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis
Blood, Liao, Chang, Hardison, Ross Cameron, Kennett, Mary J., Carlson, Bradley A., Paulson, Robert, Prabhu, Kumble Sandeep, 2018

Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics
Journal of Nutritional Biochemistry, Bora, Stephanie A., Kennett, Mary J., Smith, Philip B., Patterson, Andrew David, Cantorna, Margherita Teresa-Anna, 2018

The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23
Frontiers in immunology, Bora, Stephanie A., Kennett, Mary J., Smith, Philip B., Patterson, Andrew D., Cantorna, Margherita T., 2018

Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice
Food and Chemical Toxicology, James, Karma D., Kennett, Mary J., Lambert, Joshua D., 2018

Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells
Frontiers in immunology, Snyder, Lindsay, McDaniel, Kaitlin, Tian, Yuan, Wei, Cheng-Hsin, Kennett, Mary, Patterson, Andrew, Ross, A Catharine, None, Cantorna, Margherita, 2018

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner
Journal of Functional Foods, Hubbard, Troy D., Murray, Iain Alexander, Nichols, Robert G., Cassel, Kaitlyn, Podolsky, Michael, Kuzu, Guray, Tian, Yuan, Smith, Philip B., Kennett, Mary J., Patterson, Andrew David, Perdew, Gary H., 2017

Perinatal bisphenol a exposure induces chronic inflammation in rabbit offspring via modulation of gut bacteria and their metabolites
mSystems, Reddivari, Lavanya, Veeramachaneni, D. N.Rao, Walters, William A., Lozupone, Catherine, Palmer, Jennifer, Hewage, M. Kurundu, Bhatnagar, Rohil, Amir, Amnon, Kennett, Mary J., Knight, Rob, Vanamalae, Jairam K.P., 2017

Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors
Inflammatory bowel diseases, Saha, Piu, Chassaing, Benoit, Yeoh, Beng San, Viennois, Emilie, Xiao, Xia, Kennett, Mary J., Singh, Vishal, Vijay-Kumar, Matam, 2017

Bioactive growth hormone in older men and women
Growth Hormone and IGF Research, Kraemer, William J., Kennett, Mary J., Mastro, Andrea M., McCarter, Roger J., Rogers, Connie J., DuPont, William H., Flanagan, Shawn D., Turbitt, William J., Fragala, Maren S., Post, Emily M., Hymer, Wesley C., 2017

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Journal of Immunology, Yu, Shan, Allen, Joselyn N., Dey, Adwitia, Zhang, Limin, Balandaram, Gayathri, Kennett, Mary J., Xia, Mingcan, Xiong, Na, Peters, Jeffrey Maurice, Patterson, Andrew David, Giblin, Pamela Hankey, 2016

Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation
American Journal of Pathology, Yeoh, Beng San, Aguilera Olvera, Rodrigo, Singh, Vishal, Xiao, Xia, Kennett, Mary J., Joe, Bina, Lambert, Joshua D., Vijay-Kumar, Matam, 2016

Inhibition of interleukin-10 signaling induces microbiota-dependent chronic colitis in Apolipoprotein E deficient mice
Inflammatory bowel diseases, Singh, Vishal, Kumar, Manish, San Yeoh, Beng, Xiao, Xia, Saha, Piu, Kennett, Mary J., Kumar, Matam Vijay, 2016

Growth in egg yolk enhances salmonella enteritidis colonization and virulence in a mouse model of human colitis
PloS one, Moreau, Matthew R., Wijetunge, Dona Saumya S., Bailey, Megan L., Gongati, Sudharsan R., Goodfield, Laura L., Hewage, Eranda Mangala K.Kurundu, Kennett, Mary J., Fedorchuk, Christine, Ivanov, Yury V., Linder, Jessica E., Jayarao, Bhushan M., Kariyawasam, Subhashinie, 2016

Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells
American Journal of Physiology - Gastrointestinal and Liver Physiology, Yeoh, Beng San, Saha, Piu, Singh, Vishal, Xiao, Xia, Ying, Yun, Vanamala, Jairam K., Kennett, Mary J., Harvatine, Kevin J., Joe, Bina, Vijay-Kumar, Matam, 2016

Type six secretion system of bordetella bronchiseptica and adaptive immune components limit intracellular survival during infection
PloS one, Bendor, Liron, Weyrich, Laura S., Linz, Bodo, Rolin, Olivier Y., Taylor, Dawn L., Goodfield, Laura L., Smallridge, William E., Kennett, Mary J., Harvill, Eric Thomas, 2015

Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia
Cancer Prevention Research, Finch, Emily R., Kudva, Avinash K., Quickel, Michael D., Goodfield, Laura L., Kennett, Mary J., Whelan, Jay, Paulson, Robert F., Sandeep Prabhu, K., 2015

Vitamin A-deficient hosts become nonsymptomatic reservoirs of Escherichia coli-like enteric infections
Infection and Immunity, McDaniel, Kaitlin L., Restori, Katherine H., Dodds, Jeffery, Kennett, Mary J., Ross, A. Catharine, Cantornaa, Margherita T., 2015

Selenium suppresses leukemia through the action of endogenous eicosanoids
Cancer Research, Gandhi, Ujjawal H., Kaushal, Naveen, Hegde, Shailaja, Finch, Emily R., Kudva, Avinash K., Kennett, Mary J., Jordan, Craig T., Paulson, Robert F., Prabhu, K. Sandeep, 2014

The Effects of Continuous Application of the TASER X26 Waveform on Sus scrofa
Journal of Forensic Sciences, Jenkins, David M., Murray, W. Bosseau, Kennett, Mary J., Hughes, Edward L., Werner, Jacob R., 2013

Immunization with pneumococcal polysaccharide serotype 3 and lipopolysaccharide modulates lung and liver inflammation during a virulent Streptococcus pneumoniae infection in mice
Clinical and Vaccine Immunology, Restori, Katherine H., Kennett, Mary J., Ross, A. Catharine, 2013

(-)-epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice
Obesity, Grove, Kimberly A., Sae-Tan, Sudathip, Kennett, Mary J., Lambert, Joshua D., 2012

Comparison of the agar block and Lieber-DeCarli diets to study chronic alcohol consumption in an aging model of Fischer 344 female rats.
Journal of pharmacological and toxicological methods, Sharda, D, Miller-Lee, J, Kanski, G, Hunter, James, Lang, Charles, Kennett, Mary, Korzick, Donna, 2012

Human electromuscular incapacitation devices characterization
Journal of Strength and Conditioning Research, Werner, Jacob Robert, Jenkins, Jr., David Marion, Murray, W. Bosseau, Hughes, Edward L., Bienus, David A., Kennett, Mary J., 2012

Δ 12-prostaglandin J 3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Blood, Hegde, Shailaja, Kaushal, Naveen, Ravindra, Kodihalli C., Chiaro, Christopher, Hafer, Kelsey T., Gandhi, Ujjawal H., Thompson, Jerry T., Vanden Heuvel, John Patrick, Kennett, Mary J., Giblin, Pamela Hankey, Paulson, Robert, Prabhu, Kumble Sandeep, 2011

Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese
Journal of applied physiology, Thomas, Gwendolyn A., Kraemer, William J., Kennett, Mary J., Comstock, Brett A., Maresh, Carl M., Denegar, Craig R., Volek, Jeff S., Hymer, Wesley C., 2011

(-)-Epigallocatechin-3-gallate increases the expression of genes related to fat oxidation in the skeletal muscle of high fat-fed mice
Food and Function, Sae-Tan, Sudathip, Grove, Kimberly A., Kennett, Mary J., Lambert, Joshua D., 2011

Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection-or vaccination-induced immunity against bordetella pertussis
Infection and Immunity, Zhang, Xuqing, Hester, Sara E., Kennett, Mary J., Karanikas, Alexia T., Bendor, Liron, Place, David E., Harvill, Eric T., 2011

IACUC issues related to animal models of aging
ILAR Journal, Heiderstadt, Kathleen M., Kennett, Mary J., 2011

Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progression
Carcinogenesis, Markell, Lauren Mordasky, Pérez-Lorenzo, Rolando, Masiuk, Katelyn E., Kennett, Mary J., Glick, Adam B., 2010

Chemoprevention of chemically induced skin tumorigenesis by ligand activation of peroxisome proliferator-activated receptor-β/δ and inhibition of cyclooxygenase 2
Molecular cancer therapeutics, Zhu, Bokai, Bai, Robert, Kennett, Mary J., Kang, Boo Hyon, Gonzalez, Frank J., Peters, Jeffrey M., 2010

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
Journal of Experimental Medicine, Li, Pingxin, Li, Ming, Lindberg, Michael R., Kennett, Mary J., Xiong, Na, Wang, Yanming, 2010

Developing an engineered antimicrobial/prophylactic system using electrically activated bactericidal metals
Journal of Materials Science: Materials in Medicine, Fuller, Thomas A., Wysk, Richard A., Charumani, Charumani, Kennett, Mary J., Sebastiennelli, Wayne J., Abrahams, Rachel, Shirwaiker, Rohan A., Voigt, Robert Carl, Royer, Patricia, 2010

IL-10 induction by Bordetella parapertussis limits a protective IFN-γ response
Journal of Immunology, Wolfe, Daniel N., Karanikas, Alexia T., Hester, Sara E., Kennett, Mary J., Harvill, Eric T., 2010

Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice
Food and Chemical Toxicology, Lambert, Joshua D., Kennett, Mary J., Sang, Shengmin, Reuhl, Kenneth R., Ju, Jihyeung, Yang, Chung S., 2010