Pamela A. Hankey Giblin, Ph.D.

Pamela A. Hankey Giblin, Ph.D.

  • Professor of Immunology
  • Immunology and Infectious Disease Undergraduate Advisor
105 Henning Building
University Park, PA 16802

Areas of Expertise

  • Regulation of innate immunity, hematopoiesis and cellular transformation by receptor tyrosine kinases.

Education

  • B.S., Nutrition Science, The Pennsylvania State
  • Ph.D., Genetics, The George Washington University
  • Postdoctoral training, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto University

Graduate Programs

Teaching Areas:

Molecular immunology, signalling, macrophage biology

Research:

My laboratory studies the role of receptor tyrosine kinases in normal physiology and disease progression and the downstream signals that mediate these responses in vitro and in vivo. More specifically, we study the murine Stk receptor tyrosine kinase and its function in macrophage regulation and inflammation and in leukemic development. We have also taken advantages of differences in the Stk receptor and its human homologue, Ron, to further understand mechanisms of regulation of receptor tyrosine kinases.

Publications

Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling.
Metabolites, Allen, J, Dey, A, Cai, Jingjing, Zhang, J, Tian, Y, Kennett, Mary, Ma, Yanyuan, Liang, T, Patterson, Andrew, Hankey, Pamela, 2020

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Science signaling, Bennett, Laura F., Liao, Chang, Quickel, Michael D., Yeoh, Beng San, Vijay-Kumar, Matam, Hankey-Giblin, Pamela, Prabhu, K. Sandeep, Paulson, Robert F., 2019

Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8+ T-cell activation
Frontiers in immunology, Wang, Zhengqi, Vaughan, Tamisha Y., Zhu, Wandi, Chen, Yuhong, Fu, Guoping, Medrzycki, Magdalena, Nishio, Hikaru, Bunting, Silvia T., Hankey-Giblin, Pamela A., Nusrat, Asma, Parkos, Charles A., Wang, Demin, Wen, Renren, Bunting, Kevin D., 2019

Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model
Journal of Proteome Research, Allen, Joselyn, Zhang, Jingtao, Quickel, Michael D., Kennett, Mary J., Patterson, Andrew David, Giblin, Pamela Hankey, 2018

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Frontiers in immunology, Dey, Adwitia, Allen, Joselyn N., Fraser, James W., Snyder, Lindsay M., Tian, Yuan, Zhang, Limin, Paulson, Robert F., Patterson, Andrew, Cantorna, Margherita T., Hankey-Giblin, Pamela A., 2018

Reduced competitive repopulation capacity of multipotential hematopoietic stem cells in the bone marrow of friend virus-infected Fv2-resistant mice
In Vivo, Epperly, Michael W., Zhang, Xichen, Fisher, Renee, Hou, Wen, Franicola, Darcy, Shields, Donna, Quickel, Michael, Hankey-Giblin, Pamela, Wang, Hong, Greenberger, Joel S., 2017

Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation
Journal of Visualized Experiments, Allen, Joselyn N., Dey, Adwitia, Nissly, Ruth, Fraser, James, Yu, Shan, Balandaram, Gayathri, Peters, Jeffrey M., Hankey-Giblin, Pamela A., 2017

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Journal of Immunology, Yu, Shan, Allen, Joselyn N., Dey, Adwitia, Zhang, Limin, Balandaram, Gayathri, Kennett, Mary J., Xia, Mingcan, Xiong, Na, Peters, Jeffrey Maurice, Patterson, Andrew David, Giblin, Pamela Hankey, 2016

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
PLoS Genetics, Feaga, Heather A., Quickel, Michael D., Giblin, Pamela Hankey, Keiler, Kenneth Charles, 2016

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
Cell Communication and Signaling, Wang, Xin, Yennawar, Neela, Hankey, Pamela A., 2014

The ron receptor tyrosine kinase: a key regulator of inflammation and cancer progression.
Critical reviews in immunology, Wang, Xiaoxing, Hankey, Pamela, 2013

Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.
Toxicology and applied pharmacology, Gardner, C, Hankey, Pamela, Mishin, V, Francis, Matthew, Yu, Shaoyong, Laskin, J, Laskin, D, 2012

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53
STEM CELLS, Hegde, Shailaja, Giblin, Pamela Hankey, Paulson, Robert, 2012

Δ 12-prostaglandin J 3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Blood, Hegde, Shailaja, Kaushal, Naveen, Ravindra, Kodihalli C., Chiaro, Christopher, Hafer, Kelsey T., Gandhi, Ujjawal H., Thompson, Jerry T., Vanden Heuvel, John Patrick, Kennett, Mary J., Giblin, Pamela Hankey, Paulson, Robert, Prabhu, Kumble Sandeep, 2011

Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase
Journal of Immunology, Sharda, Daniel R., Yu, Shan, Ray, Manujendra, Squadrito, Mario Leonardo, De Palma, Michele, Wynn, Thomas A., Morris, Sidney M., Hankey, Pamela A., 2011

Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats
American Journal of Physiology - Gastrointestinal and Liver Physiology, Hegde, Narasimha V., Unger, Erica L., Jensen, Gordon L., Hankey, Pamela A., Paulson, Robert F., 2011

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein
Journal of Immunology, Ray, Manujendra, Yu, Shan, Sharda, Daniel R., Wilson, Caleph B., Liu, Qingping, Kaushal, Naveen, Prabhu, K. Sandeep, Hankey, Pamela A., 2010

Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia
Journal of Leukocyte Biology, Laskin, Debra L., Chen, Li, Hankey, Pamela A., Laskin, Jeffrey D., 2010

Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk
Journal of virology, He, Shihan, Ni, Shuang, Hegde, Shailaja, Wang, Xin, Sharda, Daniel R., August, Avery, Paulson, Robert F., Hankey, Pamela A., 2010