Pamela A. Hankey Giblin, Ph.D.

Pamela A. Hankey Giblin, Ph.D.

  • Professor of Immunology
  • Immunology and Infectious Disease Undergraduate Advisor
105 Henning Building
University Park, PA 16802

Areas of Expertise

  • Regulation of innate immunity, hematopoiesis and cellular transformation by receptor tyrosine kinases.

Education

  • B.S., Nutrition Science, The Pennsylvania State University
  • Ph.D., Genetics, The George Washington University
  • Postdoctoral training, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto University

Graduate Programs

Teaching Areas

Molecular immunology, signalling, macrophage biology

Research

My laboratory studies the role of receptor tyrosine kinases in normal physiology and disease progression and the downstream signals that mediate these responses in vitro and in vivo. More specifically, we study the murine Stk receptor tyrosine kinase and its function in macrophage regulation and inflammation and in leukemic development. We have also taken advantages of differences in the Stk receptor and its human homologue, Ron, to further understand mechanisms of regulation of receptor tyrosine kinases.

Publications

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Science's STKE : signal transduction knowledge environment, Bennett, Laura F., Liao, Chang, Quickel, Michael D., Yeoh, Beng San, Vijay-Kumar, Matam, Hankey-Giblin, Pamela, Prabhu, K. Sandeep, Paulson, Robert F., 2019

Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8+ T-cell activation
Frontiers in Immunology, Wang, Zhengqi, Vaughan, Tamisha Y., Zhu, Wandi, Chen, Yuhong, Fu, Guoping, Medrzycki, Magdalena, Nishio, Hikaru, Bunting, Silvia T., Hankey-Giblin, Pamela A., Nusrat, Asma, Parkos, Charles A., Wang, Demin, Wen, Renren, Bunting, Kevin D., 2019

Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model
Journal of Proteome Research, Allen, Joselyn, Zhang, Jingtao, Quickel, Michael D., Kennett, Mary, Patterson, Andrew D., Hankey-Giblin, Pamela A., 2018

Insights into macrophage heterogeneity and cytokine-induced neuroinflammation in major depressive disorder
Pharmaceuticals, Dey, Adwitia, Giblin, Pamela A.Hankey, 2018

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Frontiers in Immunology, Dey, Adwitia, Allen, Joselyn N., Fraser, James W., Snyder, Lindsay M., Tian, Yuan, Zhang, Limin, Paulson, Robert F., Patterson, Andrew, Cantorna, Margherita T., Hankey-Giblin, Pamela A., 2018

Reduced competitive repopulation capacity of multipotential hematopoietic stem cells in the bone marrow of friend virus-infected Fv2-resistant mice
In Vivo, Epperly, Michael W., Zhang, Xichen, Fisher, Renee, Hou, Wen, Franicola, Darcy, Shields, Donna, Quickel, Michael, Hankey-Giblin, Pamela, Wang, Hong, Greenberger, Joel S., 2017

Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation
Journal of Visualized Experiments, Allen, Joselyn N., Dey, Adwitia, Nissly, Ruth, Fraser, James, Yu, Shan, Balandaram, Gayathri, Peters, Jeffrey M., Hankey-Giblin, Pamela A., 2017

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Journal of Immunology, Yu, Shan, Allen, Joselyn N., Dey, Adwitia, Zhang, Limin, Balandaram, Gayathri, Kennett, Mary J., Xia, Mingcan, Xiong, Na, Peters, Jeffrey M., Patterson, Andrew, Hankey-Giblin, Pamela A., 2016

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
PLoS Genetics, Feaga, Heather A., Quickel, Michael D., Hankey-Giblin, Pamela A., Keiler, Kenneth C., 2016

Ontogeny and polarization of macrophages in inflammation
Frontiers in Immunology, Dey, Adwitia, Allen, Joselyn, Hankey-Giblin, Pamela A., 2015

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
Cell Communication and Signaling, Wang, Xin, Yennawar, Neela, Hankey, Pamela A., 2014

The ron receptor tyrosine kinase: a key regulator of inflammation and cancer progression.
Critical Reviews in Immunology, Wang, Xin, Giblin, Pamela Hankey, 2013

Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.
Toxicology and Applied Pharmacology, Gardner, Carol R., Hankey, Pamela, Mishin, Vladimir, Francis, Mary, Yu, Shan, Laskin, Jeffrey D., Laskin, Debra L., 2012

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53
Stem Cells, Hegde, Shailaja, Hankey, Pamela, Paulson, Robert F., 2012

Δ 12-prostaglandin J 3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Blood, Hegde, Shailaja, Kaushal, Naveen, Ravindra, Kodihalli C., Chiaro, Christopher, Hafer, Kelsey T., Gandhi, Ujjawal H., Thompson, Jerry T., Van Den Heuvel, John P., Kennett, Mary J., Hankey, Pamela, Paulson, Robert F., Prabhu, K. Sandeep, 2011

Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase
Journal of Immunology, Sharda, Daniel R., Yu, Shan, Ray, Manujendra, Squadrito, Mario Leonardo, De Palma, Michele, Wynn, Thomas A., Morris, Sidney M., Hankey, Pamela A., 2011

Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats
American Journal of Physiology, Hegde, Narasimha V., Unger, Erica L., Jensen, Gordon L., Hankey, Pamela A., Paulson, Robert F., 2011