Ruth Nissly

Ruth Nissly

  • Assistant Research Professor
Office: W-242A Millennium Science Complex
Lab: W-214 Millennium Science Complex

University Park, PA 16802

Dr. Nissly's research centers on understanding factors that enhance or limit viral infections that target mucosal surfaces. This research aims to identify potential therapeutic targets, guide approaches to prophylaxis, and inform early warning systems that flag emerging concerning strains. The viral subjects of her research include pathogens impacting both humans and animals including coronaviruses and influenza viruses.

Dr. Nissly's work also includes development of novel diagnostic assays that contribute to the Animal Diagnostic Laboratory.


The Susceptibility of Chickens to Zika Virus: A Comprehensive Study on Age-Dependent Infection Dynamics and Host Responses
Viruses, Nissly, Ruth H., Lim, Levina, Keller, Margo R., Bird, Ian M., Bhushan, Gitanjali, Misra, Sougat, Chothe, Shubhada K., Sill, Miranda C., Kumar, Nagaram Vinod, Sivakumar, A. V.N., Naik, B. Rambabu, Jayarao, Bhushan M., Kuchipudi, Suresh V., 2024

Impact of an autophagy-inducing peptide on immunogenicity and protection efficacy of an adenovirus-vectored SARS-CoV-2 vaccine
Molecular Therapy Methods and Clinical Development, Sayedahmed, Ekramy E., Araújo, Marcelo Valdemir, Silva-Pereira, Taiana Tainá, Chothe, Shubhada K., Elkashif, Ahmed, Alhashimi, Marwa, Wang, Wen Chien, Santos, Andrea P., Nair, Meera Surendran, Gontu, Abhinay, Nissly, Ruth, Francisco de Souza Filho, Antônio, Tavares, Mariana Silva, Ayupe, Marina Caçador, Salgado, Caio Loureiro, Donizetti de Oliveira Candido, Érika, Leal Oliveira, Danielle Bruna, Durigon, Edison Luiz, Heinemann, Marcos Bryan, Morais da Fonseca, Denise, Jagannath, Chinnaswamy, Sá Guimarães, Ana Marcia, Kuchipudi, Suresh V., Mittal, Suresh K., 2023

Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance
VirusDisease, Panner Selvam, Manesh Kumar, Kanagaraj, Vijayrani, Kathaperumal, Kumanan, Nissly, Ruth H., Daly, Janet M., Kuchipudi, Suresh V., 2023

Inactivation of HCoV-NL63 and SARS-CoV-2 in aqueous solution by 254 nm UV-C
Journal of Photochemistry and Photobiology B: Biology, Li, Lily X., Nissly, Ruth H., Swaminathan, Anand, Bird, Ian M., Boyle, Nina R., Nair, Meera Surendran, Greenawalt, Denver I., Gontu, Abhinay, Cavener, Victoria S., Sornberger, Ty, Freihaut, James D., Kuchipudi, Suresh V., Bahnfleth, William P., 2023

SARS-CoV-2 Prevalence and Variant Surveillance among Cats in Pittsburgh, Pennsylvania, USA
Viruses, Ramasamy, Santhamani, Gontu, Abhinay, Neerukonda, Sabarinath, Ruggiero, Diana, Morrow, Becky, Gupta, Sheweta, Amirthalingam, Saranya, Hardham, John M., Lizer, Joshua T., Yon, Michele, Nissly, Ruth H., Jakka, Padmaja, Chothe, Shubhada K., LaBella, Lindsey C., Tewari, Deepanker, Nair, Meera Surendran, Kuchipudi, Suresh Varma, 2023

Complete Genome Sequence of a Bovine Coronavirus Isolated from a Goat in Pennsylvania, USA
Genome Announcements, Chothe, Shubhada, Byukusenge, Maurice, Sekhwal, Manoj, Li, L, LaBella, Lindsey, Jakka, Padmaja, Palchak, Kay, Barry, Rhiannon, Yon, Michele, Nissly, Ruth H., Kelly, Kathleen, Jayarao, Bhushan M., Nair, Meera, Kuchipudi, Suresh Varma, 2023

Little Brown Bats (Myotis lucifugus) Support the Binding of SARS-CoV-2 Spike and Are Likely Susceptible to SARS-CoV-2 Infection
Viruses, Chothe, Shubhada K., Jakka, Padmaja, Boorla, Veda Sheersh, Ramasamy, Santhamani, Gontu, Abhinay, Nissly, Ruth H., Brown, Justin, Turner, Gregory, Sewall, Brent J., Reeder, Dee Ann M., Field, Kenneth A., Engiles, Julie B., Amirthalingam, Saranya, Ravichandran, Abirami, LaBella, Lindsey, Nair, Meera Surendran, Maranas, Costas D., Kuchipudi, Suresh V., 2023

Optimized conditions for Listeria, Salmonella and Escherichia whole genome sequencing using the Illumina iSeq100 platform with point-and-click bioinformatic analysis
PLoS One, Narvaez, Sonsiray Alvarez, Shen, Zhenyu, Yan, Lifang, Stenger, Brianna L.S., Goodman, Laura B., Lim, Ailam, Nissly, Ruth H., Nair, Meera Surendran, Zhang, Shuping, Sanchez, Susan, 2022

Mitigating the Impact of Emerging Animal Infectious Disease Threats: First Emerging Animal Infectious Diseases Conference (EAIDC) Report
Viruses, Kuchipudi, Suresh V., Behring, Deanna, Nissly, Ruth, Chothe, Shubhada K., Gontu, Abhinay, Ravichandran, Abirami, Butler, Ty, 2022

Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer
Proceedings of the National Academy of Sciences of the United States of America, Kuchipudi, Suresh V., Surendran-Nair, Meera, Ruden, R, Yon, M, Nissly, R, Vandegrift, Kurt J., Nelli, R, Li, Lingling, Jayarao, Bhushan, Maranas, Costas D., Levine, N, Willgert, K, Conlan, Andrew J.K., Conlan AJK, None, Olsen, R, Davis, J, Musser, J, Hudson, Peter John, Kapur, Vivek, 2022

SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City
Viruses, Vandegrift, Kurt, Yon, Michele, Surendran Nair, Meera, None, Surendran Nair, M, Gontu, Abhinay, Ramasamy, Santhamani, Amirthalingam, Saranya, Neerukonda, Sabarinath, Nissly, Ruth, Chothe, Shubhada, Jakka, Padmaja, LaBella, Lindsey, Levine, Nicole, Rodriguez, Sophie, Chen, C, Sheersh Boorla, Veda, None, Sheersh Boorla, V, Stuber, Tod, Boulanger, Jason, Kotschwar, Nathan, Aucoin, Sarah, Simon, Richard, Toal, Katrina, Olsen, Randall, Davis, J, Bold, Dashzeveg, Gaudreault, Natasha, Dinali Perera, Krishani, None, Dinali Perera, K, Kim, Yunjeong, Chang, Kyeong-Ok, Maranas, Costas, Richt, Juergen, Musser, James, Hudson, P, Kapur, Vivek, Kuchipudi, Suresh V., 2022

Development and Validation of Indirect Enzyme-Linked Immunosorbent Assays for Detecting Antibodies to SARS-CoV-2 in Cattle, Swine, and Chicken
Viruses, Vandegrift, Kurt, Gontu, Abhinay, Marlin, Erika, Ramasamy, Santhamani, Neerukonda, Sabarinath, Anil, Gayatri, Morgan, Jasmine, Quraishi, Meysoon, Chen, C, Boorla, Veda, Nissly, Ruth, Jakka, Padmaja, Chothe, Shubhada, Ravichandran, Abirami, Kodali, Nishitha, Amirthalingam, Saranya, LaBella, Lindsey, Kelly, Kathleen, Natesan, Pazhanivel, Minns, Allen, Rossi, Randall, Werner, Jacob R., Hovingh, Ernest, Lindner, Scott E., Tewari, Deepanker, Kapur, Vivek, Vandegrift, K, Maranas, Costas, Nair, Meera, Surendran Nair, M, Kuchipudi, Suresh V., Kuchipudi, Suresh, V, None, 2022

Transmission history of SARS-CoV-2 in humans and white-tailed deer
Scientific Reports, Willgert, Katriina, Didelot, X, Surendran-Nair, Meera, Kuchipudi, Suresh V., Ruden, R, Yon, M, Nissly, R, Vandegrift, Kurt J., Nelli, R, Li, L, Jayarao, Bhushan M., Levine, N, Olsen, R, Davis, J, Musser, J, Hudson, P, Kapur, Vivek, Conlan AJK, None, Conlan, Andrew J.K., 2022

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice
Science advances, Mabrouk, Moustafa T., Chiem, Kevin, Rujas, Edurne, Huang, Wei Chiao, Jahagirdar, Dushyant, Quinn, Breandan, Nair, Meera Surendran, Nissly, Ruth H., Cavener, Victoria S., Boyle, Nina R., Sornberger, Ty A., Kuchipudi, Suresh V., Ortega, Joaquin, Julien, Jean Philippe, Martinez-Sobrido, Luis, Lovell, Jonathan, 2021

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2
Proceedings of the National Academy of Sciences of the United States of America, Chen, Chen, Boorla, Veda Sheersh, Banerjee, Deepro, Chowdhury, Ratul, Cavener, Victoria S., Nissly, Ruth H., Gontu, Abhinay, Boyle, Nina R., Vandegrift, Kurt, Nair, Meera Surendran, Kuchipudi, Suresh V., Maranas, Costas D., 2021

Monoclonal antibodies to s and n sars-cov-2 proteins as probes to assess structural and antigenic properties of coronaviruses
Viruses, Kumar, R, Christensen, Neil D., Kaddis Maldonado, R, Bewley, Maria C., Ostman, A, Sudol, M, Chen, E, Buchkovich, N, Gontu, A, Surendran Nair, Meera, Nissly, R, Minns, A, Kapur, Vivek, Rossi, R, Kuchipudi, Suresh V., Lindner, Scott E., Parent, Leslie J., Flanagan, John M., Buchkovich, Nicholas J., 2021

A Novel Real-Time PCR Assay for the Rapid Detection of Virulent Streptococcus equi Subspecies zooepidemicus—An Emerging Pathogen of Swine
Frontiers in Veterinary Science, Kuchipudi, Suresh V., Surendran Nair, Meera, Yon, Michele, Gontu, Abhinay, Nissly, Ruth H., Barry, Rhiannon, Greenawalt, Denver, Pierre, Traci, Li, Lingling, Thirumalapura, Nagaraja, Tewari, Deepanker, Jayarao, Bhushan, 2021

Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health
Asian Pacific Journal of Tropical Medicine, Shabbir, Muhammad Zubair, Nissly, Ruth Helmus, Ahad, Abdul, Rabbani, Masood, Lim, Levina, Chothe, Shubhada K., Subbiah, Murugan, Sebastian, Aswathy, Albert, Istvan, Ul-Rahman, Aziz, Jayarao, Bhushan M., Kuchipudi, Suresh V., 2021

A Highly Sensitive and Specific Probe-Based Real-Time PCR for the Detection of Avibacterium paragallinarum in Clinical Samples From Poultry
Frontiers in Veterinary Science, Kuchipudi, Suresh, V, None, Kuchipudi, Suresh V., Yon, Michele, Nair, Meera, Surendran Nair, Meera, Byukusenge, Maurice, Barry, Rhiannon, Nissly, R, Williams, Jen, Pierre, Traci, Mathews, Tammy, Walner-Pendleton, Eva, Dunn, P, Barnhart, Denise, Loughrey, Sean, Davison, Sherrill, Kelly, Dona, Tewari, Deepanker, Jayarao, Bhushan M., 2021

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Communications Biology, Gontu, Abhinay, Srinivasan, Sreenidhi, Salazar, Eric, Nair, Meera Surendran, Nissly, Ruth, Greenawalt, Denver, Bird, Ian, Herzog, Catherine, Ferrari, Matthew J., Poojary, Indira, others, None, Katani, Robab, Lindner, Scott E., Minns, Allen M., Rossi, Randall, Christensen, Paul A., Castillo, Brian, Chen, Jian, Eagar, Todd N., Yi, Xin, Zhao, Picheng, Leveque, Christopher, Olsen, Randall J., Bernard, David W., Gollihar, Jimmy, Kuchipudi, Suresh V., Musser, James M., Kapur, Vivek, 2021

SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination
Advanced Materials, Huang, Wei Chiao, Zhou, Shiqi, He, Xuedan, Chiem, Kevin, Mabrouk, Moustafa T., Nissly, Ruth H., Bird, Ian M., Strauss, Mike, Sambhara, Suryaprakash, Ortega, Joaquin, Wohlfert, Elizabeth A., Martinez-Sobrido, Luis, Kuchipudi, Suresh V., Davidson, Bruce A., Lovell, Jonathan F., 2020

NLRC5 Serves as a Pro-viral Factor During Influenza Virus Infection in Chicken Macrophages
Frontiers in cellular and infection microbiology, Chothe, S, Nissly, R, Lim, L, Bhushan, G, Bird, I, Radzio-Basu, Jessica, Jayarao, Bhushan, Kuchipudi, Suresh V., 2020

Iminosugars With Endoplasmic Reticulum α-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro
Frontiers in Microbiology, Bhushan, Gitanjali, Lim, Levina, Bird, Ian, Chothe, Shubhada K., Nissly, Ruth H., Kuchipudi, Suresh V., 2020

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Journal of Clinical Investigation, Salazar, Eric, Kuchipudi, Suresh, Cattadori, Isabella, Christensen, Paul, Eagar, Todd, Yi, Xin, Zhao, Picheng, Jin, Zhicheng, Long, S., Olsen, Randall, Chen, Jian, Castillo, Brian, Leveque, Christopher, Towers, Dalton, Lavinder, Jason, Gollihar, Jimmy, Cardona, Jose, Ippolito, Gregory, Nissly, Ruth, Bird, Ian, Greenawalt, Denver, Rossi, Randall, Gontu, Abhinay, Srinivasan, Sreenidhi, Poojary, Indira, Cattadori, I, Hudson, Peter J., Josleyn, Nicole, Prugar, Laura, Huie, Kathleen, Herbert, Andrew, Bernard, David, Dye, John, Kapur, Vivek, Musser, James, 2020

Draft genome sequences of two virulent Streptococcus equi subsp. zooepidemicus swine isolates from Pennsylvania
Genome Announcements, Surendran Nair, M, Nair, Meera Surendran, Byukusenge, Maurice, Li, Lingling, Nissly, R, Cavener, V, Yon, Michele, Barry, Rhiannon, Natesan, Pazhanivel, Thirumalapura, Nagaraja, Tewari, Deepanker, Jayarao, Bhushan M., Kuchipudi, Suresh V., Kuchipudi, Suresh, V, None, 2020

Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD
Virology, Nissly, Ruth, Zaman, Noriza, Ibrahim, Puteri Ainaa S., None, Ibrahim, Puteri Ainaa S., Ibrahim PAS, None, McDaniel, Kaitlin, Lim, Levina, Kiser, Jennifer, Bird, Ian, Chothe, Shubhada, Bhushan, Gitanjali, Vandegrift, Kurt, Neibergs, Holly, Kuchipudi, Suresh, V, None, Kuchipudi, Suresh V., 2020

Complete Genome Sequences of Seven Avibacterium paragallinarum Isolates from Poultry Farms in Pennsylvania, USA
Genome Announcements, Byukusenge, Maurice, Nissly, Ruth, Li, Lingling, Pierre, Traci, Mathews, Tammy, Wallner-Pendleton, Eva, Dunn, Patricia, Barnhart, Denise, Loughrey, Sean, Davison, Sherrill, Kelly, Donna, Tewari, Deepanker, Tewari, BDeepanker, Jayarao, Bhushan M., Kuchipudi, Suresh V., Kuchipudi, Suresh, V, None, 2020

A probe-based real-time PCR assay for the detection of Neospora caninum in clinical samples from cattle
Veterinary Parasitology, Barry, R, Nissly, R, Feria, W, Thirumalapura, N, Tewari, D, Jayarao, Bhushan, Kuchipudi, Suresh V., 2019

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells
Emerging Microbes and Infections, Pujhari, Sujit, Brustolin, Marco, Macias, Vanessa M., Nissly, Ruth H., Nomura, Masashi, Kuchipudi, Suresh V., Rasgon, Jason, 2019

Acoustofluidic Fluorescence Activated Cell Sorter
Analytical Chemistry, Nawaz, Ahmad Ahsan, Chen, Yuchao, Nama, Nitesh, Nissly, Ruth Helmus, Ren, Liqiang, Ozcelik, Adem, Wang, Lin, McCoy, J. Philip, Levine, Stewart J., Huang, Tony Jun, 2015

Immunological Analyses of Whole Blood via “Microfluidic Drifting” Based Flow Cytometric Chip
Annals of Biomedical Engineering, Nawaz, Ahmad Ahsan, Nissly, Ruth Helmus, Li, Peng, Chen, Yuchao, Guo, Feng, Li, Sixing, Shariff, Yasir M., Qureshi, Arooj Nawaz, Wang, Lin, Huang, Tony Jun, 2014

Differential analysis of lysed whole blood via "Microfluidic drifting" based flow cytometry chip, Nawaz, Ahmad Ahsan, Nissly, Ruth Helmus, Li, Peng, Shariff, Yasir M., Wang, Lin, Huang, Tony Jun, 2014