Robert F. Paulson, Ph.D.
- Professor of Veterinary and Biomedical Sciences
University Park, PA 16802
- Email rfp5@psu.edu
- Office 814-863-6306
Areas of Expertise
- Hematology
- Erythropoiesis
- Anemia Research
- Leukemia
Websites
Education
- Postdoctoral training, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
- PhD, Biochemistry, University of California, San Francisco, CA
- BA, Biochemistry, Northwestern University, Evanston, IL
Graduate Programs
- Molecular Cellular Integrative Biosciences (MCIBS)
- Integrative and Biomedical Physiology
Research
Mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress.
Work in the Paulson lab focuses on the mechanisms that regulate tissue regeneration. Throughout adult life, tissues become damaged and must be repaired or regenerated to maintain homeostasis. We focus on the maintenance of erythrocytes or red blood cells. Steady state erythropoiesis generates new erythrocytes at a constant rate of about 2.5 x 106/second. Despite this enormous capacity, there are times when this process cannot produce enough erythrocytes. For example, infection inhibits the ability of the bone marrow to generate erythrocytes. Similarly, in response to anemia the bone marrow production of erythrocytes is not sufficient to maintain normal blood levels. At these times stress erythropoiesis rapidly produces large numbers of erythrocytes to maintain homeostasis until the bone marrow can resume production. This process is a stem cell mediated process as hematopoietic stem cells directly generate stress erythroid progenitors. Furthermore, the signals that regulate this process are distinct from steady state erythropoiesis and are more associated with embryonic development than hematopoiesis suggesting that stress erythropoiesis is similar to other tissue regeneration processes.
Publications
A novel clinically relevant graft-versus-leukemia model in humanized mice
Journal of Leukocyte Biology, Jia, Bei, Zhao, Chenchen, Bayerl, Michael, Shike, Hiroko, Claxton, David F., Ehmann, W. Christopher, Mineishi, Shin, Schell, Todd D., Zheng, Pan, Zhang, Yi, Shultz, Leonard D., Prabhu, K. Sandeep, Paulson, Robert F., Zheng, Hong, 2021
Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization
Bioorganic and Medicinal Chemistry Letters, Hengst, Jeremy A., Hegde, Shailaja, Paulson, Robert F., Yun, Jong K., 2020
Stress erythropoiesis
Experimental Hematology, Paulson, Robert F., Hariharan, Sneha, Little, Jane A., 2020
Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation
Blood, Chen, Yuanting, Xiang, Jie, Qian, Fenghua, Diwakar, Bastihalli T., Ruan, Baiye, Hao, Siyang, Prabhu, K. Sandeep, Paulson, Robert F., 2020
Stress Erythropoiesis is a Key Inflammatory Response
Cells, Paulson, Robert F., Ruan, Baiye, Hao, Siyang, Chen, Yuanting, 2020
Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration
Experimental Hematology, Hao, Siyang, Matsui, Yurika, Lai, Zhi Chun, Paulson, Robert F., 2019
Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium
FASEB Journal, Diwakar, Bastihalli T., Yoast, Ryan, Nettleford, Shaneice, Qian, Fenghua, Lee, Tai Jung, Berry, Svanjita, Huffnagle, Ian, Rossi, Randall M., Trebak, Mohamed, Paulson, Robert F., Prabhu, K. Sandeep, 2019
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Science's STKE : signal transduction knowledge environment, Bennett, Laura F., Liao, Chang, Quickel, Michael D., Yeoh, Beng San, Vijay-Kumar, Matam, Hankey-Giblin, Pamela, Prabhu, K. Sandeep, Paulson, Robert F., 2019
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche
Blood advances, Hao, Siyang, Xiang, Jie, Wu, Dai Chen, Fraser, James W., Ruan, Baiye, Cai, Jingwei, Patterson, Andrew D., Lai, Zhi Chun, Paulson, Robert F., 2019
Downregulation of CD73 associates with T cell exhaustion in AML patients
Journal of Hematology and Oncology, Kong, Yaxian, Jia, Bei, Zhao, Chenchen, Claxton, David, Sharma, Arati, Annageldiyev, Charyguly, Fotos, Joseph, Zeng, Hui, Paulson, Robert, Prabhu, Kumble Sandeep, Zheng, Hong, 2019
Epo receptor marks the spot
Blood, Paulson, Robert F., 2019
Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth
DNA and Cell Biology, Matsui, Yurika, Zhang, Yifan, Paulson, Robert F., Lai, Zhi Chun, 2019
Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia
Blood, Liao, Chang, Sandeep Prabhu, K., Paulson, Robert F., 2018
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis
Cell Discovery, Rothberg, Janet L.Manias, Maganti, Harinad B., Jrade, Hani, Porter, Christopher J., Palidwor, Gareth A., Cafariello, Christopher, Battaion, Hannah L., Khan, Safwat T., Perkins, Theodore J., Paulson, Robert F., Ito, Caryn Y., Stanford, William L., 2018
Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis
Blood, Liao, Chang, Hardison, Ross Cameron, Kennett, Mary J., Carlson, Bradley A., Paulson, Robert, Prabhu, Kumble Sandeep, 2018
Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Frontiers in Immunology, Dey, Adwitia, Allen, Joselyn N., Fraser, James W., Snyder, Lindsay M., Tian, Yuan, Zhang, Limin, Paulson, Robert F., Patterson, Andrew, Cantorna, Margherita T., Hankey-Giblin, Pamela A., 2018
Mechanisms of erythrocyte development and regeneration
Journal of Embryology and Experimental Morphology, Bresnick, Emery H., Hewitt, Kyle J., Mehta, Charu, Keles, Sunduz, Paulson, Robert F., Johnson, Kirby D., 2018
Stress erythropoiesis model systems, Bennett, Laura F., Liao, Chang, Paulson, Robert F., 2018
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia
Developmental Cell, Hewitt, Kyle J., Katsumura, Koichi R., Matson, Daniel R., Devadas, Prithvia, Tanimura, Nobuyuki, Hebert, Alexander S., Coon, Joshua J., Kim, Jin Soo, Dewey, Colin N., Keles, Sunduz, Hao, Siyang, Paulson, Robert F., Bresnick, Emery H., 2017
Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia
Blood, Finch, Emily R., Tukaramrao, Diwakar B., Goodfield, Laura L., Quickel, Michael D., Paulson, Robert F., Prabhu, K. Sandeep, 2017
The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium, Diwakar, Bastihalli T., Korwar, Arvind M., Paulson, Robert F., Prabhu, K. Sandeep, 2017
SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models
Cancer Translational Medicine, Hengst, Jeremy, Dick, Taryn E., Sharma, Arati, Doi, Kenichiro, Hegde, Shailaja, Tan, Su Fern, Geffert, Laura, Fox, Todd E., Sharma, Arun K., Desai, Dhimant, Amin, Shantu, Kester, Mark, Loughran, Thomas P., Paulson, Robert, Claxton, David, Wang, Hong-Gang, Yun, Jong, 2017
TLR stimulation increases erythrophagocytosis and induces stress erythropoiesis
Experimental Hematology, Paulson, Robert, 2016
Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia
Cancer Prevention Research, Finch, Emily R., Kudva, Avinash K., Quickel, Michael D., Goodfield, Laura L., Kennett, Mary J., Whelan, Jay, Paulson, Robert F., Sandeep Prabhu, K., 2015
In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors
Blood, Xiang, Jie, Wu, Dai Chen, Chen, Yuanting, Paulson, Robert F., 2015
Selenium suppresses leukemia through the action of endogenous eicosanoids
Cancer Research, Gandhi, Ujjawal H., Kaushal, Naveen, Hegde, Shailaja, Finch, Emily R., Kudva, Avinash K., Kennett, Mary J., Jordan, Craig T., Paulson, Robert F., Prabhu, K. Sandeep, 2014
Targeting a new regulator of erythropoiesis to alleviate anemia
Nature Medicine, Paulson, Robert F., 2014
Polycomb-like 2 (PCL2) is required for hematopoietic development
Experimental Hematology, Paulson, Robert, 2014
Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin
PLoS One, Kudva, Avinash K., Kaushal, Naveen, Mohinta, Sonia, Kennett, Mary J., August, Avery, Paulson, Robert F., Prabhu, K. Sandeep, 2013
Enu Mutagenesis Identifies a Novel Platelet Phenotype in a Loss-Of-Function Jak2 Allele
PLoS One, Anderson, Nicole M., Javadi, Mojib, Berndl, Elizabeth, Berberovic, Zorana, Bailey, Monica L., Huang, Kai, Flenniken, Ann M., Osborne, Lucy R., Adamson, S. Lee, Rossant, Janet, Carter-Su, Christin, Wang, Chen, McNagny, Kelly M., Paulson, Robert F., Minden, Mark D., Stanford, William L., Barber, Dwayne L., 2013
Epo Dependent Signaling In Macrophages Regulates Stress Erythropoiesis
Blood, Paulson, Robert, 2013
Endogenous levels of D12-PGJ3 derived from eicosapentaenoic acid
Blood, Prabhu, K. Sandeep, Paulson, Robert F., 2012
Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53
Stem Cells, Hegde, Shailaja, Hankey, Pamela, Paulson, Robert F., 2012
Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.
Experimental Hematology, Anderson, N, Berberovic, Z, Berndl, E, Bailey, Moya, Flenniken, A, Osborne, L, Adamson, S, Rossant, J, Wang, Chao-Yang, Minden, M, McNagny, K, Paulson, Robert, Barber, D, Stanford, W, 2012
Δ 12-prostaglandin J 3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Blood, Hegde, Shailaja, Kaushal, Naveen, Ravindra, Kodihalli C., Chiaro, Christopher, Hafer, Kelsey T., Gandhi, Ujjawal H., Thompson, Jerry T., Vanden Heuvel, John Patrick, Kennett, Mary J., Giblin, Pamela Hankey, Paulson, Robert, Prabhu, Kumble Sandeep, 2011
Erythropoiesis lagging? pIgA1 steps in to assist Epo
Nature Medicine, Paulson, Robert F., 2011
Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D 2 synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ
Journal of Biological Chemistry, Gandhi, Ujjawal H., Kaushal, Naveen, Ravindra, Kodihalli C., Hegde, Shailaja, Nelson, Shakira M., Narayan, Vivek, Vunta, Hema, Paulson, Robert F., Prabhu, K. Sandeep, 2011
Stress erythropoiesis
Current Opinion in Hematology, Paulson, Robert, Shi, Lei, Wu, Dai Chen, 2011
The regulation of erythropoiesis by selenium in mice
Antioxidants and Redox Signaling, Kaushal, Naveen, Hegde, Shailaja, Lumadue, Jeanne, Paulson, Robert F., Prabhu, K. Sandeep, 2011
Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats
American Journal of Physiology, Hegde, Narasimha V., Unger, Erica L., Jensen, Gordon L., Hankey, Pamela A., Paulson, Robert F., 2011
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.
Experimental Hematology, Hughes, M, Anderson, Nancy, Maltby, S, Wong, J, Berberovic, Z, Birkenmeier, C, Haddon, D, Garcha, K, Flenniken, A, Osborne, L, Adamson, S, Rossant, J, Peters, L, Minden, M, Paulson, Robert, Wang, Chao-Yang, Barber, D, McNagny, K, Stanford, W, 2011
BMP and WNT pathway regulation of lineage specific gene programs underlie hematopoietic regeneration
Experimental Hematology, Paulson, Robert, 2011
