Robert F. Paulson, Ph.D.

Robert F. Paulson, Ph.D.

  • Professor of Veterinary and Biomedical Sciences
108B Research Building A (Temporary Office until New AVBS building is completed)
University Park, PA 16802

Areas of Expertise

  • Hematology
  • Erythropoiesis
  • Anemia Research
  • Leukemia

Education

  • Postdoctoral training, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
  • PhD, Biochemistry, University of California, San Francisco, CA
  • BA, Biochemistry, Northwestern University, Evanston, IL

Graduate Programs

  • Molecular Cellular Integrative Biosciences (MCIBS)
  • Integrative and Biomedical Physiology 

Research

Mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress.

Work in the Paulson lab focuses on the mechanisms that regulate tissue regeneration. Throughout adult life, tissues become damaged and must be repaired or regenerated to maintain homeostasis. We focus on the maintenance of erythrocytes or red blood cells. Steady state erythropoiesis generates new erythrocytes at a constant rate of about 2.5 x 106/second. Despite this enormous capacity, there are times when this process cannot produce enough erythrocytes. For example, infection inhibits the ability of the bone marrow to generate erythrocytes. Similarly, in response to anemia the bone marrow production of erythrocytes is not sufficient to maintain normal blood levels. At these times stress erythropoiesis rapidly produces large numbers of erythrocytes to maintain homeostasis until the bone marrow can resume production. This process is a stem cell mediated process as hematopoietic stem cells directly generate stress erythroid progenitors. Furthermore, the signals that regulate this process are distinct from steady state erythropoiesis and are more associated with embryonic development than hematopoiesis suggesting that stress erythropoiesis is similar to other tissue regeneration processes.

      

Publications

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Diwakar, Bastihalli T., Yoast, Ryan, Nettleford, Shaneice, Qian, Fenghua, Lee, Tai Jung, Berry, Svanjita, Huffnagle, Ian, Rossi, Randall M., Trebak, Mohamed, Paulson, Robert F., Prabhu, K. Sandeep, 2019

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Science signaling, Bennett, Laura F., Liao, Chang, Quickel, Michael D., Yeoh, Beng San, Vijay-Kumar, Matam, Hankey-Giblin, Pamela, Prabhu, K. Sandeep, Paulson, Robert F., 2019

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche
Blood Advances, Hao, Siyang, Xiang, Jie, Wu, Dai Chen, Fraser, James W., Ruan, Baiye, Cai, Jingwei, Patterson, Andrew D., Lai, Zhi Chun, Paulson, Robert F., 2019

Downregulation of CD73 associates with T cell exhaustion in AML patients
Journal of Hematology and Oncology, Kong, Yaxian, Jia, Bei, Zhao, Chenchen, Claxton, David, Sharma, Arati, Annageldiyev, Charyguly, Fotos, Joseph, Zeng, Hui, Paulson, Robert, Prabhu, Kumble Sandeep, Zheng, Hong, 2019

Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration
Experimental Hematology, Hao, Siyang, Matsui, Yurika, Lai, Zhi Chun, Paulson, Robert F., 2019

Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth
DNA and Cell Biology, Matsui, Yurika, Zhang, Yifan, Paulson, Robert F., Lai, Zhi Chun, 2019

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia
Blood, Liao, Chang, Sandeep Prabhu, K., Paulson, Robert F., 2018

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis
Cell Discovery, Rothberg, Janet L.Manias, Maganti, Harinad B., Jrade, Hani, Porter, Christopher J., Palidwor, Gareth A., Cafariello, Christopher, Battaion, Hannah L., Khan, Safwat T., Perkins, Theodore J., Paulson, Robert F., Ito, Caryn Y., Stanford, William L., 2018

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis
Blood, Liao, Chang, Hardison, Ross Cameron, Kennett, Mary J., Carlson, Bradley A., Paulson, Robert, Prabhu, Kumble Sandeep, 2018

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Frontiers in immunology, Dey, Adwitia, Allen, Joselyn N., Fraser, James W., Snyder, Lindsay M., Tian, Yuan, Zhang, Limin, Paulson, Robert F., Patterson, Andrew, Cantorna, Margherita T., Hankey-Giblin, Pamela A., 2018

The intricate role of selenium and selenoproteins in erythropoiesis
Free Radical Biology and Medicine, Liao, Chang, Carlson, Bradley A., Paulson, Robert F., Prabhu, K. Sandeep, 2018

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia
Developmental Cell, Hewitt, Kyle J., Katsumura, Koichi R., Matson, Daniel R., Devadas, Prithvia, Tanimura, Nobuyuki, Hebert, Alexander S., Coon, Joshua J., Kim, Jin Soo, Dewey, Colin N., Keles, Sunduz, Hao, Siyang, Paulson, Robert F., Bresnick, Emery H., 2017

Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia
Blood, Finch, Emily R., Tukaramrao, Diwakar B., Goodfield, Laura L., Quickel, Michael D., Paulson, Robert F., Prabhu, K. Sandeep, 2017

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models
Cancer Translational Medicine, Hengst, Jeremy, Dick, Taryn E., Sharma, Arati, Doi, Kenichiro, Hegde, Shailaja, Tan, Su Fern, Geffert, Laura, Fox, Todd E., Sharma, Arun K., Desai, Dhimant, Amin, Shantu, Kester, Mark, Loughran, Thomas P., Paulson, Robert, Claxton, David, Wang, Hong-Gang, Yun, Jong, 2017

The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium.
Advances in cancer research, Diwakar, B, Korwar, A, Paulson, Robert, Prabhu, Kumble, 2017

Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia
Cancer Prevention Research, Finch, Emily R., Kudva, Avinash K., Quickel, Michael D., Goodfield, Laura L., Kennett, Mary J., Whelan, Jay, Paulson, Robert F., Sandeep Prabhu, K., 2015

In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors
Blood, Xiang, Jie, Wu, Dai Chen, Chen, Yuanting, Paulson, Robert F., 2015

Selenium suppresses leukemia through the action of endogenous eicosanoids
Cancer Research, Gandhi, Ujjawal H., Kaushal, Naveen, Hegde, Shailaja, Finch, Emily R., Kudva, Avinash K., Kennett, Mary J., Jordan, Craig T., Paulson, Robert F., Prabhu, K. Sandeep, 2014

Targeting a new regulator of erythropoiesis to alleviate anemia.
Nature medicine, Paulson, Robert, 2014

Enu Mutagenesis Identifies a Novel Platelet Phenotype in a Loss-Of-Function Jak2 Allele
PloS one, Anderson, Nicole M., Javadi, Mojib, Berndl, Elizabeth, Berberovic, Zorana, Bailey, Monica L., Huang, Kai, Flenniken, Ann M., Osborne, Lucy R., Adamson, S. Lee, Rossant, Janet, Carter-Su, Christin, Wang, Chen, McNagny, Kelly M., Paulson, Robert F., Minden, Mark D., Stanford, William L., Barber, Dwayne L., 2013

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53
STEM CELLS, Hegde, Shailaja, Giblin, Pamela Hankey, Paulson, Robert, 2012

Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.
Experimental hematology, Anderson, N, Berberovic, Z, Berndl, E, Bailey, Moya, Flenniken, A, Osborne, L, Adamson, S, Rossant, J, Wang, Chao-Yang, Minden, M, McNagny, K, Paulson, Robert, Barber, D, Stanford, W, 2012

Δ 12-prostaglandin J 3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Blood, Hegde, Shailaja, Kaushal, Naveen, Ravindra, Kodihalli C., Chiaro, Christopher, Hafer, Kelsey T., Gandhi, Ujjawal H., Thompson, Jerry T., Vanden Heuvel, John Patrick, Kennett, Mary J., Giblin, Pamela Hankey, Paulson, Robert, Prabhu, Kumble Sandeep, 2011

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
Cell, Trompouki, Eirini, Bowman, Teresa V., Lawton, Lee N., Fan, Zi Peng, Wu, Dai Chen, Dibiase, Anthony, Martin, Corey S., Cech, Jennifer N., Sessa, Anna K., Leblanc, Jocelyn L., Li, Pulin, Durand, Ellen M., Mosimann, Christian, Heffner, Garrett C., Daley, George Q., Paulson, Robert F., Young, Richard A., Zon, Leonard I., 2011

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D 2 synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ
Journal of Biological Chemistry, Gandhi, Ujjawal H., Kaushal, Naveen, Ravindra, Kodihalli C., Hegde, Shailaja, Nelson, Shakira M., Narayan, Vivek, Vunta, Hema, Paulson, Robert F., Prabhu, K. Sandeep, 2011

Stress erythropoiesis
Current Opinion in Hematology, Paulson, Robert, Shi, Lei, Wu, Dai Chen, 2011

The regulation of erythropoiesis by selenium in mice
Antioxidants and Redox Signaling, Kaushal, Naveen, Hegde, Shailaja, Lumadue, Jeanne Ann, Paulson, Robert, Prabhu, Kumble Sandeep, 2011

Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats
American Journal of Physiology - Gastrointestinal and Liver Physiology, Hegde, Narasimha V., Unger, Erica L., Jensen, Gordon L., Hankey, Pamela A., Paulson, Robert F., 2011

A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.
Experimental hematology, Hughes, M, Anderson, Nancy, Maltby, S, Wong, J, Berberovic, Z, Birkenmeier, C, Haddon, D, Garcha, K, Flenniken, A, Osborne, L, Adamson, S, Rossant, J, Peters, L, Minden, M, Paulson, Robert, Wang, Chao-Yang, Barber, D, McNagny, K, Stanford, W, 2011

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors
Journal of Clinical Investigation, Harandi, Omid F., Hedge, Shailaja, Wu, Dai Chen, Mckeone, Daniel, Paulson, Robert F., 2010

Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia
PLoS One, Wu, Dai Chen, Paulson, Robert, 2010

Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk
Journal of virology, He, Shihan, Ni, Shuang, Hegde, Shailaja, Wang, Xin, Sharda, Daniel R., August, Avery, Paulson, Robert F., Hankey, Pamela A., 2010