Suresh V Kuchipudi, BVSc & AH, MVSc, PhD, Diplomate ACVM
- Clinical Associate Professor and Section Head
- Mammalian Virology,Immunology
- and Avian Influenza
Lab: 814-863-5737
University Park, PA 16802
Areas of Expertise
- Diagnostic Virology & Serology
- Zoonotic and Emerging Viruses
- Negative strand RNA viruses
- Avian and Mammalian influenza
- Immune responses to viruses
- Viral pathogenesis
- Quantitative-omics approach to virus-host interactions
Connect with Suresh V Kuchipudi, BVSc & AH, MVSc, PhD, Diplomate ACVM
Education
- •PhD, Institute of comparative medicine, University of Glasgow, Glasgow UK,
- •Postgraduate certificate in higher education (PGCHE), University of Nottingham,UK,
- •MVSc, Tamil Nadu veterinary and Animal Sciences University, Chennai, India,
- •BVSc & AH, Acharya N.G. Ranga Agricultural University, Hyderabad, India,
Honorary positions
Adjunct Professor (March 2016-March 2019),
Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu,India
Board Certification
Graduate Programs•2014, Diplomate, American College of Veterinary Microbiologists (DACVM), Virology
Molecular Cellular and Integrative Biosciences (MCIBS)
Teaching
•MICRB 410- Principles of Immunology
• VBSC-496- Independent Studies
Research
The goal of Dr. Kuchipudi's research is to generate knowledge that can underpin the development of novel diagnostic tools and intervention therapies for endemic and emerging viral diseases of animals and humans.
Current research in the Kuchipudi lab involves a range of viruses of veterinary and zoonotic importance.
Ongoing Projects
Influenza A viruses:
•Role of Nod Like Receptors (NLRs) in virus pathogenesis
• The interplay between influenza viruses and alveolar macrophages
•Investigating the role of bats as a potential reservoir of influenza A viruses (IAVs)
Corona Viruses:
Flaviviruses:•Comparative genomics of Bovine coronaviruses (BCoVs)
•Molecular pathogenesis of Zika virus
Herpes viruses:
•Comparhttps://www.ncbi.nlm.nih.gov/nuccore/?term=kuchipudi+svative genomics of clinical and vaccine strains of Bovine Herpes Virus-1 (BHV-1)
Center for Infectious Disease Dynamics
Molecular, Cellular and Integrative Bio-sciences
Animal Diagnostics Research Faculty
Center for Research on Advanced Fiber Technologies (CRAFT)
Professional Memberships
- American Association of Veterinary Laboratory Diagnosticians (AAVLD)
- Fellowship of Higher Education academy (HEA), UK
- American College of Veterinary Microbiologists (ACVM)
- Society for General Microbiology (SGM), UK
- Veterinary Public Health Association (VPHA) UK,
- Veterinary Council of India (VCI)
- Indian Association of Veterinary Microbiologists, Immunologists and Specialists in Infectious Disease (IAVMI).
Selected Publications:
Shabbir MZ, Nissly RH, Ahad A, Rabbani M, Chothe SK, Sebastian A, Albert I, Jayarao BM, Kuchipudi SV. 2018. Complete genome sequences of three related avian avulavirus 1 isolates from poultry farmers in Pakistan. Genome Announc 6:e00361-18. https://doi.org/10.1128/genomeA.00361-18.
Shubhada K. Chothe, Aswathy Sebastian, Asha Thomas, Ruth Nissly, Maurice Byukusenge, David Wolfgang, Sunil Kumar Mor, Sagar Goyal, Istvan Albert, Bhushan Jayarao, and Suresh V. Kuchipudi*. 2018,Whole-Genome Sequences of 18 Bovine Alphaherpesvirus 1 Field Isolates from Pennsylvania and Minnesota,Genome Announc. April 2018; 6:doi:10.1128/genomeA.00294-18
Kay Palchak, Shubhada K. Chothe, Aswathy Sebastian, Ruth H. Nissly, Rhiannon Barry, Istvan Albert, Bhushan M. Jayarao, and Suresh V. Kuchipudi*, 2018, Whole-Genome Sequence of Infectious Pancreatic Necrosis Virus Isolated from Farmed Brook Trout (Salvelinus fontinalis) in Pennsylvania, Genome Announc. April 2018; 6:doi:10.1128/genomeA.00360-18
Vasudevan G, Vanamayya PR, Nagarajan S, Rajukumar K, Suba, S, Venketash G, Tosh C, Sood R, Nissly RH, and Kuchipudi SV*. 2017. Infectious dose-dependent accumulation of live highly pathogenic avian influenza H5N1 virus in chicken skeletal muscle—implications for public health. Zoonoses and Public Health. 2017;00:1–5. https://doi.org/10.1111/zph.12406
Rathnapraba Sambandham , Raja Angamuthu, Vijayarani Kanagaraj, Kumanan Kathaperumal, Shubhada K. Chothe, Ruth H. Nissly, Rhiannon M. Barry, Bhushan M. Jayarao and Suresh V. Kuchipudi*. 2017. An immuno-chromatographic lateral flow assay (LFA) for rapid on-the-farm detection of classical swine fever virus (CSFV). Archives of Virology, DOI 10.1007/s00705-017-3464-4
Shubhada K Chothe, Gitanjali Bhushan, Ruth H. Nissly, Yin-Ting Yeh, Justin Brown, Gregory Turner, Jenny Fisher, Brent J. Sewall, DeeAnn M. Reeder, Mauricio Terrones, Bhushan M Jayarao and Suresh V Kuchipudi*. 2017. Avian and human influenza virus compatible sialic acid receptors in little brown bats. Scientific reports, 7: 660 DOI:10.1038/s41598-017-00793-6
Naveen Gujjar, Shubhada K. Chothe,Shashikant Gawai,Ruth Nissly,Gitanjali Bhushan, Vijayarani Kanagaraj,Bhushan M. Jayarao,Kumanan Kathaperumal, Madhuri Subbiah, and Suresh V. Kuchipudi*.2016. Co-expression of sialic acid receptors compatible with avian and human influenza virus binding in emus (Dromaius novaehollandiae). Virology. Volume 500, January 2017, Pages 114–121, http://dx.doi.org/10.1016/j.virol.2016.10.021
Chhabra,R., Kuchipudi, S.V*., Chantrey, J and Ganapathy, K. 2016. Pathogenicity and tissue tropism of infectious bronchitis virus is associated with elevated apoptosis and innate immune responses. Virology, Volume 488, 15 January 2016, Pages 232-241
Chothe, S. K., B. M. Jayarao and S. V. Kuchipudi*. 2015. Targeting cellular and virus encoded LncRNAs: Emerging opportunities for novel anti-influenza therapies. British Journal of Virology, 2(6): 102-105.
Chang, P.,Kuchipudi, S.V#., Mellits, K.H., Sebastian, S., James, J., Liu, J., Shelton, H and Chang, K.C. 2015.Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation. Sci Rep. 2015 Dec 8;5:17999. doi: 10.1038/srep17999.
Sebastian, S., Goulding, L., Kuchipudi, S. V and Chang, K. C. 2015. Extended 2D myotube culture recapitulates postnatal fibre type plasticity.BMC Cell Biol. 2015 Sep 17;16(1):23.
Kuchipudi, S. V.* 2015. The complex role of STAT3 in viral infections. J Immunol Res. Vol. 2015, Article ID 272359, 9 pages, doi:10.1155/2015/272359.
Kuchipudi, S. V.*, Dunham S. P., and Chang, K. C. 2015. DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells. Genomics Data. Vol. 4, June 2015, Pages 60–64, doi:10.1016/j.gdata.2015.03.004,
Baquero-Perez, B., Kuchipudi, S. V., Ho, J., Sebastian, S., Puranik, A., Howard, W., Brookes, S. M., Brown, I. H., and Chang, K. C. 2015. Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection. J Virol. 89(5):2494-2506.
Kuchipudi, S. V.* and Chang, K. 2015. Skeletal muscle in influenza virus infection- a key player or a bystander? Brit J Virol. 2(2): 19-21.
Saravanan, S., Purushothaman, V., Murthy, T., K. Sukumar, P. Srinivasan, V. Gowthaman, M., Balusamy, R., Atterbury, and Kuchipudi, S. V. 2015. Molecular epidemiology of nontyphoidal Salmonella in poultry and poultry products in India: Implications for human health. Indian J Microbiol. 55(3): 319-326.
Kuchipudi, S. V.*, Tellabati, M., Sebastian, S., Londt, B. Z., Jansen, C., Vervelde, L., Brookes, S. M., Brown, I. H., Dunham, S. P., and Chang K. C. 2014. Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses. Vet Res. 45:118.
Seng, L. G., Daly, J., Chang K. C., and Kuchipudi, S. V.* 2014. High basal expression of interferon-stimulated genes in human bronchial epithelial (BEAS-2B) cells contributes to influenza A virus resistance. PLoS ONE. 9(10): e109023. doi:10.1371/journal.pone.0109023.
Roychoudhury, P., Sarma, D. K., Rajkhowa, S., and Kuchipudi, S. V.* 2014. Predominance of genotype 1.1 and emergence of genotype 2.2 classical swine fever viruses in north-eastern region of India. Transbound and Emerg Dis. Aug; 61 Suppl s1:69-77.
Arumugam, U., Vijayarani, K., Kumanan, K., Bhuvaneswari, S., Kuchipudi, S. V., and Elankumaran, S. 2014. Complete genome sequence of a velogenic Nnwcastle disease virus isolated from an apparently healthy village chicken in South India. Genome Announc. May/Jun 19;2(3).
Kuchipudi, S. V*., Tellabati, M., Nelli, R. K., White, G. A., Baquero-Perez, B., Sebastian, S., Slomka, M. J., Brookes, S. M., Brown, I. H., Dunham, S. P. and Chang, K. C. 2012. 18S rRNA is a reliable normalisation gene for real time PCR derived from influenza virus infected cells. Virol J. 9:230.
Kuchipudi, S. V., Dunham, S. P., Nelli, R. K., White, G. A., Perez, B. B., Brown, I., and Chang, K. C. 2012. Rapid death of duck cells infected with Influenza A: a mechanism for host resistance to H5N1. Immunol Cell Biol. 90:116-123.
Nelli, R. K., Dunham, S. P., Kuchipudi, S. V., White, G. A., Baquero-Perez, B., Chang, P., Ghaemmaghami, A., Brookes, S. M., Brown, I. H., and Chang, K. C. 2012. Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced pro-inflammation and infectious virus release. J Virol. 86: 9201-9210.
Baquero-Perez, B., Kuchipudi, S. V#., Nelli, R. K., and Chang, K. C. 2012. A simplified but robust method for the isolation of avian and mammalian muscle satellite cells. BMC Cell Biol. 13:16.
Alkurashi, M., Eastick, F. A., Kuchipudi, S. V., Rauch, C., Madouasse, A., Zhu, X. Q., and Elsheikha, H. M. 2011. Influence of culture medium pH on internalization, growth and phenotypic plasticity of Neospora caninum, Vet Parasitol. Vol. 177, no. 3-4, pp. 267-274.
Nelli, R. K., Kuchipudi, S. V., White, G. A., Perez, B. B., Dunham, S. P. and Chang, K. C. 2010.Comparative distribution of human and avian type sialic acid influenza receptors in the pig. BMC Vet.Res. 6:4.
Kuchipudi, S. V., Nelli, R., White, G. A., Bain, M., Chang, K. C., and Dunham, S. 2009. Differences in influenza virus receptors in chickens and ducks: Implications for interspecies transmission. J Mol Genet Med. Vol. 3, no. 1, pp. 143-151.
*Corresponding author.
# Equal contribution.