Troy Sutton, PhD
- Assistant Professor of Veterinary and Biomedical Sciences
- Email tcs38@psu.edu
Areas of Expertise
- Animal models of influenza
- Airborne transmission of influenza viruses
- Evolution of pandemic influenza viruses
- Highly pathogenic avian influenza
- Development of live-attenuated influenza vaccine platforms
- High containment BSL3+ research
Publications
Virology under the Microscope-a Call for Rational Discourse.
Journal of virology, Goodrum, F, Lowen, A, Lakdawala, S, Alwine, J, Casadevall, A, Imperiale, M, Atwood, W, Avgousti, D, Baines, J, Banfield, B, Banks, L, Bhaduri-McIntosh, S, Bhattacharya, D, Blanco-Melo, D, Bloom, D, Boon, A, Boulant, S, Brandt, C, Broadbent, A, Brooke, C, Cameron, C, Campos, S, Caposio, P, Chan, G, Cliffe, A, Coffin, J, Collins, K, Damania, B, Daugherty, M, Debbink, K, DeCaprio, J, Dermody, T, Dikeakos, J, DiMaio, D, Dinglasan, R, Duprex, W, Dutch, R, Elde, N, Emerman, M, Enquist, L, Fane, B, Fernandez-Sesma, A, Flenniken, M, Frappier, L, Frieman, M, Frueh, K, Gack, M, Gaglia, M, Gallagher, T, Galloway, D, García-Sastre, A, Geballe, A, Glaunsinger, B, Goff, S, Greninger, A, Hancock, M, Harris, E, Heaton, N, Heise, M, Heldwein, E, Hogue, B, Horner, S, Hutchinson, E, Hyser, J, Jackson, W, Kalejta, R, Kamil, J, Karst, S, Kirchhoff, F, Knipe, D, Kowalik, T, Lagunoff, M, Laimins, L, Langlois, R, Lauring, A, Lee, B, Leib, D, Liu, S, Longnecker, R, Lopez, C, Luftig, M, Lund, J, Manicassamy, B, McFadden, G, McIntosh, M, Mehle, A, Miller, W, Mohr, I, Moody, C, Moorman, N, Moscona, A, Mounce, B, Munger, J, Münger, K, Murphy, E, Naghavi, M, Nelson, J, Neufeldt, C, Nikolich, J, O'Connor, C, Ono, A, Orenstein, W, Ornelles, D, Ou, J, Parker, J, Parrish, C, Pekosz, A, Pellett, P, Pfeiffer, J, Plemper, R, Polyak, S, Purdy, J, Pyeon, D, Quinones-Mateu, M, Renne, R, Rice, C, Schoggins, J, Roller, R, Russell, C, Sandri-Goldin, R, Sapp, M, Schang, L, Schmid, S, Schultz-Cherry, S, Semler, B, Shenk, T, Silvestri, G, Simon, V, Smith, G, Smith, J, Spindler, K, Stanifer, M, Subbarao, K, Sundquist, W, Suthar, M, Sutton, Troy, Tai, A, Tarakanova, V, tenOever, B, Tibbetts, S, Tompkins, S, Toth, Z, van Doorslaer, K, Vignuzzi, M, Wallace, N, Walsh, D, Weekes, M, Weinberg, J, Weitzman, M, Weller, S, Whelan, S, White, E, Williams, B, Wobus, C, Wong, S, Yurochko, A, 2023
Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.
bioRxiv : the preprint server for biology, Patel, D, Moustafa, Ibrahim, Minns, A, Sims, D, Field, C, Kerr, A, Heinly, T, Luley, E, Rossi, R, Bator, C, Mostafa, I, Hafenstein, Susan, Lindner, S, Sutton, Troy, 2022
Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans
mBio, Sutton, Troy C., Lamirande, Elaine W., Patel, Devanshi R., Johnson, Katherine E.E., Czako, Rita, Ghedin, Elodie, Lee, Raphael T.C., Maurer-Stroh, Sebastian, Subbarao, Kanta, 2022
Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene
Journal of Virology, Mo, Jong Suk, Abente, Eugenio J., Perez, Matias Cardenas, Sutton, Troy C., Cowan, Brianna, Ferreri, Lucas M., Geiger, Ginger, Gauger, Phillip C., Perez, Daniel R., Vincent Baker, Amy L., Rajao, Daniela S., 2022
Changes in the Hemagglutinin and Internal Gene Segments Were Needed for Human Seasonal H3 Influenza A Virus to Efficiently Infect and Replicate in Swine
Pathogens, Rajao, Daniela S., Abente, Eugenio J., Powell, Joshua D., Bolton, Marcus J., Gauger, Phillip C., Arruda, Bailey, Anderson, Tavis K., Sutton, Troy C., Perez, Daniel R., Vincent Baker, Amy L., 2022
Defining the relationship between inoculation dose and transmission for the 2009 H1N1 and 1968 H3N2 pandemic influenza viruses, Septer, Kayla, Field, Cassandra, Patel, Devanshi, Sim, D, Sutton, Troy, 2022
Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters., Field, Cassandra, Heinly, Talia, Patel, Devanshi, Sim, D, Luley, Erin, Gupta, S, Vanderford, Thomas, Wrammert, Jens, Sutton, Troy, 2022
The role of vaccine-induced intranasal immunity on transmission of pandemic H1N1 in the ferret model., Septer, Kayla, Sim, D, Patel, Devanshi, Field, Cassandra, Heinly, Talia, Norton, Elizabeth, Sutton, Troy, 2022
Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 Pandemic
mSphere, Derr, Thomas, James, Melissa, Kuny, Chad, Patel, Devanshi, Kendell, Prem, Kandel, Prem, Field, Cassandra, Beckman, Matthew, Hockett, Kevin L., Bates, Mark, Sutton, Troy, Szpara, Moriah L., 2022
Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise
mBio, Belser, Jessica A., Lau, Eric H.Y., Barclay, Wendy, Barr, Ian G., Chen, Hualan, Fouchier, Ron A.M., Hatta, Masato, Herfst, Sander, Kawaoka, Yoshihiro, Lakdawala, Seema S., Yi Yang Lee, Leo, Neumann, Gabriele, Peiris, Malik, Perez, Daniel R., Russell, Charles, Subbarao, Kanta, Sutton, Troy C., Webby, Richard J., Yang, Huanliang, Yen, Hui Ling, 2022
Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters., Field, Cassandra, Heinly, Talia, Patel, Devanshi, Sim, D, Luley, Erin, Gupta, S, Vanderford, Thomas, Wrammert, Jens, Sutton, Troy, 2022
Intranasal vaccination with hemagglutinin or neuraminidase reduces airborne transmission of pandemic H1N1 in ferrets, Septer, Kayla, Sim, D, Patel, Devanshi, Field, Cassandra, Heinly, Talia, Sutton, Troy, 2022
Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs
Nutrients, Arora, Juhi, Patel, Devanshi, Nicol, McKayla, Field, Cassandra, Restori, Katherine, Wang, Jinpeng, Froelich, Nicole, Katkere, Bhuvana, Terwilliger, Josey, Weaver, Veronika, others, None, Luley, Erin, Kelly, Kathleen, Kirimanjeswara, Girish S., Sutton, Troy, Cantorna, Margherita T., 2022
Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters
Emerging Microbes and Infections, Field, C, Heinly, T, Patel, D, Sim, D. G., Luley, E., Gupta, S, Vanderford, T, Wrammert, J, Sutton, T. C., 2022
Transmission and protection against reinfection in the ferret model with the SARS-CoV-2 USA-WA1/2020 reference isolate
Journal of Virology, Patel, Devanshi, Field, Cassandra, Septer, Kayla, Sim, Derek G., Jones, Matthew J., Heinly, T, Vanderford, Thomas, McGraw, Elizabeth A., Sutton, Troy, 2021
Development of a swine RNA polymerase I driven Influenza reverse genetics system for the rescue of type A and B Influenza viruses
Journal of Virological Methods, Seibert, Brittany, Angel, Matthew, Caceres, C. Joaquin, Sutton, Troy, Kumar, Ayush, Ferreri, Lucas, Cardenas-Garcia, Stivalis, Geiger, Ginger, Rajao, Daniela, Perez, Daniel R., 2021
A Global Cross-laboratory Exercise to Improve Standardization of Ferret Transmission Studies, Besler, Jessica, Yen, Hui-Ling, Septer, Kayla, Sim, D, Sutton, Troy, 2021
Anti-N1 antibodies induced by intramuscular vaccination do not block airborne transmission of pandemic H1N1 influenza A in ferrets, Septer, Kayla, Sim, D, Patel, Devanshi, Field, Cassandra, Heinly, Talia, Sutton, Troy, 2021
Anti-N1 antibodies induced by intramuscular vaccination do not block airborne transmission of pandemic H1N1 influenza A in ferrets, Septer, Kayla, Patel, Devanshi, Sutton, Troy, 2020
Sequential Airborne Transmission of Influenza Viruses in Ferrets: A Potential Strategy to Evaluate Vaccine Efficacy, Sutton, Troy, Czako, Rita, Lamirande, Elaine, Joseph, Renuka, Subbarao, Kanta, 2018
The pandemic threat of emerging H5 and H7 avian influenza viruses
Viruses, Sutton, Troy C., 2018
Homologous and heterologous protection against influenza B virus following live attenuated influenza virus (LAIV) immunization.
Journal of Immunology, Santos, J, Finch, C, Sutton, Troy, Obadan, A, Aguirre, I, Wan, Z, Lopez, D, Gieger, G, Gonzalez, A, Ferreri, L, Perez, D, 2018
H5N2 vaccine viruses on Russian and US live attenuated influenza virus backbones demonstrate similar infectivity, immunogenicity and protection in ferrets
Vaccine, Czakó, Rita, Vogel, Leatrice, Sutton, Troy, Matsuoka, Yumiko, Krammer, Florian, Chen, Zhongying, Jin, Hong, Subbarao, Kanta, 2018
Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines
npj Vaccines, Sutton, Troy C., Chakraborty, Saborni, Mallajosyula, Vamsee V.A., Lamirande, Elaine W., Ganti, Ketaki, Bock, Kevin W., Moore, Ian N., Varadarajan, Raghavan, Subbarao, Kanta, 2017
In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice
Journal of Virology, Sutton, Troy C., Lamirande, Elaine W., Bock, Kevin W., Moore, Ian N., Koudstaal, Wouter, Rehman, Muniza, Weverling, Gerrit Jan, Goudsmit, Jaap, Subbarao, Kanta, 2017
Evaluation of the biological properties and cross-reactive antibody response to h10 influenza viruses in ferrets
Journal of Virology, Sutton, Troy C., Lamirande, Elaine W., Czako, Rita, Subbarao, Kanta, 2017
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody
PLoS Pathogens, Houser, Katherine V., Broadbent, Andrew J., Gretebeck, Lisa, Vogel, Leatrice, Lamirande, Elaine W., Sutton, Troy, Bock, Kevin W., Minai, Mahnaz, Orandle, Marlene, Moore, Ian N., Subbarao, Kanta, 2017
Seasonal, Pandemic, and Emerging Influenza Viruses Transmit with Similar Efficiency Over Sequential Rounds of Airborne Contact in Ferrets, Sutton, Troy, Czako, Rita, Lamirande, Elaine, Joseph, Renuka, Subbarao, Kanta, 2017
Development of an alternative modified live influenza B virus vaccine
Journal of Virology, Santos, Jefferson J.S., Finch, Courtney, Sutton, Troy, Obadan, Adebimpe, Aguirre, Isabel, Wan, Zhimin, Lopez, Diego, Geiger, Ginger, Gonzalez-Reiche, Ana Silvia, Ferreri, Lucas, Perez, Daniel R., 2017
Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice
Journal of General Virology, Kuah, Li Fang, Tang, Lay Hoon, Sutton, Troy, Lim, Jie Hui, Sin, Wan Ling, Lamirande, Elaine, Subbarao, Kanta, Lau, Yuk Fai, 2017
Evaluation of replication and cross-reactive antibody response of twenty H10 influenza viruses in ferrets, Sutton, Troy, Lamirande, Elaine, Subbarao, Kanta, 2016
Bacterially expressed influenza group 2 hemagglutinin stem-immunogen vaccines protect mice from lethal challenge, Sutton, Troy, Mallajosyula, V, Lamirande, Elaine, Varadarajan, Raghavan, Subbarao, Kanta, 2016
Prophylaxis with broadly neutralizing monoclonal antibodies CR6261 and CR9114 protects mice against lethal H2 influenza virus challenge., Sutton, Troy, Lamirande, E, Rehman, M, Weverling, G, Goudsmit, J, Subbarao, Kanta, 2015
Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus
Virology, Sutton, Troy C., Subbarao, Kanta, 2015
Novel reassortant human-like H3N2 and H3N1 influenza A viruses detected in pigs are virulent and antigenically distinct from swine viruses endemic to the United States
Journal of Virology, Rajão, D, Gauger, P, Anderson, T, Lewis, N, Abente, E, Killian, M, Perez, D, Sutton, Troy, Zhang, J, Vincent, A, 2015
Genome rearrangement of influenza virus for anti-viral drug screening
Virus Research, Sutton, Troy C., Obadan, Adebimpe, Lavigne, Johanna, Chen, Hongjun, Li, Weizhong, Perez, Daniel R., 2014
Airborne transmission of highly pathogenic H7N1 in ferrets., Sutton, Troy, Finch, C, Shao, H, Angel, M, Chen, H, Capau, I, Cattoli, G, Monne, I, Perez, Daniel, 2014
All-in-one bacmids: An efficient reverse genetics strategy for influenza a virus vaccines
Journal of Virology, Chen, Hongjun, Angel, Matthew, Li, Weizhong, Finch, Courtney, Gonzalez, Ana Silvia, Sutton, Troy, Santos, Jefferson, Perez, Daniel R., 2014
Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I
Journal of Virology, Li, Weizhong, Chen, Hongjun, Sutton, Troy, Obadan, Adebimpe, Perez, Daniel R., 2014
Alternative reassortment events leading to transmissible h9n1 influenza viruses in the ferret model
Journal of Virology, Kimble, Brian J., Angel, Matthew, Wan, Hongquan, Sutton, Troy C., Finch, Courtney, Perez, Daniel R., 2014
Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets
Journal of Virology, Sutton, Troy C., Finch, Courtney, Shao, Hongxia, Angel, Matthew, Chen, Hongjun, Capua, Ilaria, Cattoli, Giovanni, Monne, Isabella, Pereza, Daniel R., 2014
MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies
Nature Biotechnology, Langlois, Ryan A., Albrecht, Randy A., Kimble, Brian, Sutton, Troy, Shapiro, Jillian S., Finch, Courtney, Angel, Matthew, Chua, Mark A., Gonzalez-Reiche, Ana Silvia, Xu, Kemin, Perez, Daniel, García-Sastre, Adolfo, Tenoever, Benjamin R., 2013
Molecular risk mitigation of gain-of-function studies with influenza studies., Langlois, R, Albrecht, R, Kimble, B, Sutton, Troy, Shapiro, J, Finch, C, Angel, M, Chua, M, Gonzalez-Reiche, A, Xu, K, Perez, D, García-Sastre, A, tenOever, B, 2013
Airborne transmission of highly pathogenic H7N1 in ferrets., Sutton, Troy, Finch, C, Shao, H, Angel, M, Chen, H, Capau, I, Cattoli, G, Monne, I, Perez, Daniel, 2013
Influenza viruses with rearranged genomes as live-attenuated vaccines
Journal of Virology, Pena, Lindomar, Sutton, Troy, Chockalingam, Ashok, Kumar, Sachin, Angel, Matthew, Shao, Hongxia, Chen, Hongjun, Li, Weizhong, Perez, Daniel R., 2013
Receptor Characterization and Susceptibility of Cotton Rats to Avian and 2009 Pandemic Influenza Virus Strains
Journal of Virology, Blanco, Jorge C.G., Pletneva, Lioubov M., Wan, Hongquan, Araya, Yonas, Angel, Matthew, Oue, Raymonde O., Sutton, Troy C., Perez, Daniel R., 2013