Troy Sutton, PhD

Troy Sutton, PhD

  • Assistant Professor of Veterinary and Biomedical Sciences
University Park, PA 16802

Areas of Expertise

  • Animal models of influenza
  • Airborne transmission of influenza viruses
  • Evolution of pandemic influenza viruses
  • Highly pathogenic avian influenza
  • Development of live-attenuated influenza vaccine platforms
  • High containment BSL3+ research

Publications

Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans
mBio, Sutton, Troy C., Lamirande, Elaine W., Patel, Devanshi R., Johnson, Katherine E.E., Czako, Rita, Ghedin, Elodie, Lee, Raphael T.C., Maurer-Stroh, Sebastian, Subbarao, Kanta, 2022

Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene
Journal of Virology, Mo, Jong Suk, Abente, Eugenio J., Perez, Matias Cardenas, Sutton, Troy C., Cowan, Brianna, Ferreri, Lucas M., Geiger, Ginger, Gauger, Phillip C., Perez, Daniel R., Vincent Baker, Amy L., Rajao, Daniela S., 2022

Changes in the Hemagglutinin and Internal Gene Segments Were Needed for Human Seasonal H3 Influenza A Virus to Efficiently Infect and Replicate in Swine
Pathogens, Rajao, Daniela S., Abente, Eugenio J., Powell, Joshua D., Bolton, Marcus J., Gauger, Phillip C., Arruda, Bailey, Anderson, Tavis K., Sutton, Troy C., Perez, Daniel R., Vincent Baker, Amy L., 2022

Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 Pandemic
mSphere, Derr, T. Hans, James, Melissa A., Kuny, Chad V., Patel, Devanshi R., Kandel, Prem P., Field, Cassandra, Beckman, Matthew D., Hockett, Kevin L., Bates, Mark A., Sutton, Troy C., Szpara, Moriah L., 2022

Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs
Nutrients, Arora, Juhi, Patel, Devanshi R., Nicol, McKayla J., Field, Cassandra J., Restori, Katherine H., Wang, Jinpeng, Froelich, Nicole E., Katkere, Bhuvana, Terwilliger, Josey A., Weaver, Veronika, Luley, Erin, Kelly, Kathleen, Kirimanjeswara, Girish S., Sutton, Troy C., Cantorna, Margherita T., 2022

Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise
mBio, Belser, Jessica A., Lau, Eric H.Y., Barclay, Wendy, Barr, Ian G., Chen, Hualan, Fouchier, Ron A.M., Hatta, Masato, Herfst, Sander, Kawaoka, Yoshihiro, Lakdawala, Seema S., Yi Yang Lee, Leo, Neumann, Gabriele, Peiris, Malik, Perez, Daniel R., Russell, Charles, Subbarao, Kanta, Sutton, Troy C., Webby, Richard J., Yang, Huanliang, Yen, Hui Ling, 2022

Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters
Emerging Microbes and Infections, Field, C. J., Heinly, T. A., Patel, D. R., Sim, D. G., Luley, E., Gupta, S. L., Vanderford, T. H., Wrammert, J., Sutton, T. C., 2022

Transmission and protection against reinfection in the ferret model with the SARS-CoV-2 USA-WA1/2020 reference isolate
Journal of Virology, Patel, Devanshi, Field, Cassandra, Septer, Kayla, Sim, Derek G., Jones, Matthew J., Heinly, Talia A., Vanderford, Thomas, McGraw, Elizabeth A., Sutton, Troy C., 2021

Development of a swine RNA polymerase I driven Influenza reverse genetics system for the rescue of type A and B Influenza viruses
Journal of Virological Methods, Seibert, Brittany, Angel, Matthew, Caceres, C. Joaquin, Sutton, Troy, Kumar, Ayush, Ferreri, Lucas, Cardenas-Garcia, Stivalis, Geiger, Ginger, Rajao, Daniela, Perez, Daniel R., 2021

A Global Cross-laboratory Exercise to Improve Standardization of Ferret Transmission Studies, Besler, Jessica, Yen, Hui-Ling, Septer, Kayla, Sim, D, Sutton, Troy, 2021

Anti-N1 antibodies induced by intramuscular vaccination do not block airborne transmission of pandemic H1N1 influenza A in ferrets, Septer, Kayla, Sim, D, Patel, Devanshi, Field, Cassandra, Heinly, Talia, Sutton, Troy, 2021

Anti-N1 antibodies induced by intramuscular vaccination do not block airborne transmission of pandemic H1N1 influenza A in ferrets, Septer, Kayla, Patel, Devanshi, Sutton, Troy, 2020

Sequential Airborne Transmission of Influenza Viruses in Ferrets: A Potential Strategy to Evaluate Vaccine Efficacy, Sutton, Troy, Czako, Rita, Lamirande, Elaine, Joseph, Renuka, Subbarao, Kanta, 2018

Homologous and heterologous protection against influenza B virus following live attenuated influenza virus (LAIV) immunization.
Journal of Immunology, Santos, J, Finch, C, Sutton, Troy, Obadan, A, Aguirre, I, Wan, Z, Lopez, D, Gieger, G, Gonzalez, A, Ferreri, L, Perez, D, 2018

H5N2 vaccine viruses on Russian and US live attenuated influenza virus backbones demonstrate similar infectivity, immunogenicity and protection in ferrets
Vaccine, Czakó, Rita, Vogel, Leatrice, Sutton, Troy, Matsuoka, Yumiko, Krammer, Florian, Chen, Zhongying, Jin, Hong, Subbarao, Kanta, 2018

Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines
npj Vaccines, Sutton, Troy C., Chakraborty, Saborni, Mallajosyula, Vamsee V.A., Lamirande, Elaine W., Ganti, Ketaki, Bock, Kevin W., Moore, Ian N., Varadarajan, Raghavan, Subbarao, Kanta, 2017

In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice
Journal of Virology, Sutton, Troy C., Lamirande, Elaine W., Bock, Kevin W., Moore, Ian N., Koudstaal, Wouter, Rehman, Muniza, Weverling, Gerrit Jan, Goudsmit, Jaap, Subbarao, Kanta, 2017

Evaluation of the biological properties and cross-reactive antibody response to h10 influenza viruses in ferrets
Journal of Virology, Sutton, Troy C., Lamirande, Elaine W., Czako, Rita, Subbarao, Kanta, 2017

Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody
PLoS Pathogens, Houser, Katherine V., Broadbent, Andrew J., Gretebeck, Lisa, Vogel, Leatrice, Lamirande, Elaine W., Sutton, Troy, Bock, Kevin W., Minai, Mahnaz, Orandle, Marlene, Moore, Ian N., Subbarao, Kanta, 2017

Seasonal, Pandemic, and Emerging Influenza Viruses Transmit with Similar Efficiency Over Sequential Rounds of Airborne Contact in Ferrets, Sutton, Troy, Czako, Rita, Lamirande, Elaine, Joseph, Renuka, Subbarao, Kanta, 2017

Development of an alternative modified live influenza B virus vaccine
Journal of Virology, Santos, Jefferson J.S., Finch, Courtney, Sutton, Troy, Obadan, Adebimpe, Aguirre, Isabel, Wan, Zhimin, Lopez, Diego, Geiger, Ginger, Gonzalez-Reiche, Ana Silvia, Ferreri, Lucas, Perez, Daniel R., 2017

Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice
Journal of General Virology, Kuah, Li Fang, Tang, Lay Hoon, Sutton, Troy, Lim, Jie Hui, Sin, Wan Ling, Lamirande, Elaine, Subbarao, Kanta, Lau, Yuk Fai, 2017

Evaluation of replication and cross-reactive antibody response of twenty H10 influenza viruses in ferrets, Sutton, Troy, Lamirande, Elaine, Subbarao, Kanta, 2016

Bacterially expressed influenza group 2 hemagglutinin stem-immunogen vaccines protect mice from lethal challenge, Sutton, Troy, Mallajosyula, V, Lamirande, Elaine, Varadarajan, Raghavan, Subbarao, Kanta, 2016

Prophylaxis with broadly neutralizing monoclonal antibodies CR6261 and CR9114 protects mice against lethal H2 influenza virus challenge., Sutton, Troy, Lamirande, E, Rehman, M, Weverling, G, Goudsmit, J, Subbarao, Kanta, 2015

Novel reassortant human-like H3N2 and H3N1 influenza A viruses detected in pigs are virulent and antigenically distinct from swine viruses endemic to the United States
Journal of Virology, Rajão, Daniela S., Gauger, Phillip C., Anderson, Tavis K., Lewis, Nicola S., Abente, Eugenio J., Killian, Mary Lea, Perez, Daniel R., Sutton, Troy C., Zhang, Jianqiang, Vincent, Amy L., 2015

Genome rearrangement of influenza virus for anti-viral drug screening
Virus Research, Sutton, Troy C., Obadan, Adebimpe, Lavigne, Johanna, Chen, Hongjun, Li, Weizhong, Perez, Daniel R., 2014

Airborne transmission of highly pathogenic H7N1 in ferrets., Sutton, Troy, Finch, C, Shao, H, Angel, M, Chen, H, Capau, I, Cattoli, G, Monne, I, Perez, Daniel, 2014

All-in-one bacmids: An efficient reverse genetics strategy for influenza a virus vaccines
Journal of Virology, Chen, Hongjun, Angel, Matthew, Li, Weizhong, Finch, Courtney, Gonzalez, Ana Silvia, Sutton, Troy, Santos, Jefferson, Perez, Daniel R., 2014

Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I
Journal of Virology, Li, Weizhong, Chen, Hongjun, Sutton, Troy, Obadan, Adebimpe, Perez, Daniel R., 2014

Alternative reassortment events leading to transmissible h9n1 influenza viruses in the ferret model
Journal of Virology, Kimble, Brian J., Angel, Matthew, Wan, Hongquan, Sutton, Troy C., Finch, Courtney, Perez, Daniel R., 2014

Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets
Journal of Virology, Sutton, Troy C., Finch, Courtney, Shao, Hongxia, Angel, Matthew, Chen, Hongjun, Capua, Ilaria, Cattoli, Giovanni, Monne, Isabella, Pereza, Daniel R., 2014

MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies
Nature Biotechnology, Langlois, Ryan A., Albrecht, Randy A., Kimble, Brian, Sutton, Troy, Shapiro, Jillian S., Finch, Courtney, Angel, Matthew, Chua, Mark A., Gonzalez-Reiche, Ana Silvia, Xu, Kemin, Perez, Daniel, García-Sastre, Adolfo, Tenoever, Benjamin R., 2013

Molecular risk mitigation of gain-of-function studies with influenza studies., Langlois, R, Albrecht, R, Kimble, B, Sutton, Troy, Shapiro, J, Finch, C, Angel, M, Chua, M, Gonzalez-Reiche, A, Xu, K, Perez, D, García-Sastre, A, tenOever, B, 2013

Airborne transmission of highly pathogenic H7N1 in ferrets., Sutton, Troy, Finch, C, Shao, H, Angel, M, Chen, H, Capau, I, Cattoli, G, Monne, I, Perez, Daniel, 2013

Influenza viruses with rearranged genomes as live-attenuated vaccines
Journal of Virology, Pena, Lindomar, Sutton, Troy, Chockalingam, Ashok, Kumar, Sachin, Angel, Matthew, Shao, Hongxia, Chen, Hongjun, Li, Weizhong, Perez, Daniel R., 2013

Receptor Characterization and Susceptibility of Cotton Rats to Avian and 2009 Pandemic Influenza Virus Strains
Journal of Virology, Blanco, Jorge C.G., Pletneva, Lioubov M., Wan, Hongquan, Araya, Yonas, Angel, Matthew, Oue, Raymonde O., Sutton, Troy C., Perez, Daniel R., 2013