K. Sandeep Prabhu, PhD
- Post-doc, Center for Molecular Toxicology, Penn State University
- PhD, Biochemistry, VMSRF-University of Mysore, India
- MSc, Biochemistry, University of Mysore, India
- BSc, Biochemistry, Yuvaraja College, University of Mysore, India
VB SC 514 (NUTRN 514) Prostaglandins and Leukotrienes (Alternate Sp semester)
The course provides an in-depth coverage of how fatty acids are metabolized in eukaryotes by various enzymatic and non-enzymatic mechanisms. The course will emphasize on the physiological roles of these fatty acid oxidation products in general health, inflammation, and reproduction along with their cellular basis of action via receptor-dependent and -independent mechanisms. (3 Credits)
VB SC 451 Immunotoxicology of Drugs and Chemicals (Coordinator: Dr. Prabhu/Co-instructor: Dr. Na Xiong) (Fa semester)
The immunotoxicology course will focus primarily on the effects of environmental chemicals, therapeutics, and recreational drugs on the immune system. Immunomodulatory mechanisms will be examined at systemic, cellular and molecular levels. Discussions will include theory, principles, and methodology and key issues in immunotoxicology. (3 Credits)
VB SC 330 Introduction to Molecular Pharmacology (Coordinator: Dr. Adam Glick/Co-instructor: Dr. Prabhu) (Sp Semester)
Molecular interactions between drugs and their tissue receptors and possible modifications of drugs to target different receptors will be discussed. Drugs used to treat infectious disease, cardiovascular disease, immune modulators, and anti-cancer drugs will be examined for their molecular interactions. Students will understand the complexities of new drug design and development from the initial stages of laboratory development to final approval for use by the Food and Drug Administration. (3 Credits)
Research projects in our laboratory focus on the following areas:
- Effect of selenium on leukemia stem cells.
- Targeting leukemia using novel lipid mediators derived from n-3 and n-6 fatty acids.
- Redox-dependent changes in the metabolome in immune cells and its relevance in disease pathogenesis.
- Effect of selenium and selenoproteins on gut inflammation with an emphasis on eicosanoid metabolism and macrophage polarization.
- Effect of host selenoproteins in helminth infection.
- Redox regulation of erythropoiesis.
- The role of selenoproteins in HIV1 transcription.
Targeting of leukemia stem cells: In collaboration with Dr. Robert Paulson
Finch ER, A.K. Kudva, M. D. Quickel, L. L. Goodfield, M. J. Kennett, J. Whelan, R. F. Paulson, and Prabhu K. S. (2015) Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia. Cancer Prev. Res. (Phila). 2015 Aug 19. pii: canprevres.0050.2015. [Epub ahead of print]
Narayan V, Kudva AK, Prabhu K. S. Reduction of tetrathionate by mammalian thioredoxin reductase. Biochemistry. 2015 Aug 25;54(33):5121-4. [Spotlight in: Chem. Res. Toxicol. Oct 2015]
Kudva AK, A. E. Shay, and Prabhu K.S (2015) Selenium and inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 309; G71-7.
Narayan V, Kodihalli RC, Liao C, Kaushal N, Carlson BA, and Prabhu K.S. Epigenetic regulation of inflammatory gene expression in macrophages by selenium. J Nutr Biochem. 2015 Feb;26(2):138-45
Kaushal, N., Kudva, A. K., Patterson, A. D., Chiaro, C., Kennett, M. J., Desai, D., Amin, S., Carlson, B. A., Cantorna, M. T., and Prabhu, K. S. Crucial role of macrophage selenoproteins in experimental colitis. J Immunol. 193(7):3683-92, 2014.
Gandhi, U. H., Kaushal, N., Hegde, S., Finch, E., Kudva, A. K., Kennett, M. J., Jordan, C. T., Paulson, R. F., and Prabhu, K. S. Role of endogenous eicosanoids in the suppression of leukemia by selenium. Cancer Res. (In Press).
Vijay Kumar, M., Prabhu, K. S., and Rogers, C. J. The Microbiome and obesity-an established risk for certain types of cancer. Cancer J. 20(3):176-80, 2014.
Kudva, A., Kaushal, N., Mohinta, S., Kennett, M. J., August, A., Paulson, R. F., and Prabhu, K. S. Stability, bioavailability, and hypersensitivity of omega-3 derived anti-leukemic D12-PGJ3. PLoS One. Dec 2:8(12), 2013.
Chen Y-C., Prabhu, K. S., and Mastro, A. Dietary selenium supplementation modifies breast tumor growth and metastasis. Int J Cancer. 133; 2054-64, 2013.
Flock, M. R., Rogers, C. J., Prabhu, K. S., and Kris-Etherton, P. M. Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. Diabetes Metab Res Rev. 29; 431-45, 2013.
Ravindra, K. C., Narayan, V., Lushington, G. H., Peterson, B. R., and Prabhu, K. S. Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ(12)-PGJ(2) through Covalent Binding to Cys(1438). Chem Res Toxicol. Feb 20; 25(2): 337-47, 2012.
Hegde, S., Kaushal, N., Ravindra, K. C., Chiaro, C., Hafer, K. T., Gandhi, U. H., Thompson, J. T., Vanden Heuvel, J. P., Kennett, M. J., Hankey, P., Paulson, R. F., Prabhu, K.S. Delta12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. Blood. Dec. 22; 118(26):6909-19, 2011.
Gandhi, U. H., Kaushal, N., Ravindra, K. C. , Hegde, S., Nelson, S. M., Narayan, V., Vunta, H., Paulson, R. F., and Prabhu, K. S. Selenoprotein-dependent Up-regulation of Hematopoietic Prostaglandin D2 Synthase in Macrophages Is Mediated through the Activation of Peroxisome Proliferator-activated Receptor (PPAR)g. J Biol Chem. 286:27471-82, 2011.
Nelson, S. M., Lei, X., and Prabhu, K. S. Selenium Levels Affect the IL-4–Induced Expression of Alternative Activation Markers in Murine Macrophages. J Nutr. Sept.; 141:1754-61, 2011.
Kaushal, N., Hegde, S., Paulson, R. F., and Prabhu, K. S. The regulation of erythropoiesis by selenium. Antiox Redox Signal. 14:1403-12, 2011.
Narayan, V., Ravindra, K. C., Chiaro, C., Carey, D., Aggarwal, B. B., Henderson, A. J., and Prabhu, K. S. Celastrol inhibits tat-dependent human immunodeficiency virus (HIV) transcription and replication. J Mol Biol. 410(5):972-83, 2011.
Chen, Y-C., Sosnoski, D., Gandhi, U. H., Novinger, L., Prabhu*, K. S., and Mastro*, A. M. Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. Carcinogenesis. 30(11):1941-8, 2009. (*Corresponding authors)
Kalantari, P., Narayan, V., Henderson, A. J., and Prabhu, K. S. 15-deoxy-PGJ2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. FASEB J. Aug.; 23(8):2366-73, 2009.
Palempalli, U. D., Gandhi, U., Kalantari, P., Vunta, H., Arner, R. J., Narayan, V., Ravindran, A., and Prabhu, K.S. Gambogic acid covalently modifies IkB-kinase-b subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kB in macrophages. Biochem J. Apr. 15; 419(2):401-409, 2009.
Kalantari, P., Narayan, V., Natarajan, S. K., Muralidhar, K., Gandhi, U. H., Vunta, H., Henderson, A. J., and Prabhu, K. S. Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein Tat-dependent transcription in human macrophages. J Biol Chem. Nov 28; 283(48):33183-90, 2008.
Vunta, H., Davis, F., Palempalli, U. D., Bhat, D., Arner, R. J., Thompson, J. T., Peterson, D. G., Reddy, C. C., and Prabhu, K. S. The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. J Biol Chem. June 22; 282(25):17964-73, 2007.
Coleman, J. D., Prabhu, K. S., Thompson, J. T., Reddy, P. S., Peters, J. M., Peterson, B. R., Reddy, C. C., Vanden Heuvel, J. P. The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Free Radic Biol Med. Apr 15; 42(8):1155-64, 2007.
Prabhu, K.S., Kudva, A. K., and Nelson, S.M. Selenium mediates a switch in macrophage polarization in "Diversity of Selenium Function in Health and Disease" Eds. R. Brigelius-Flohe and H. Sies. CRC Press; Chapter 14, pp 293-308, 2016
Kaushal, N., Narayan, V., Gandhi, U. H., Nelson, S. M., Kotha, A.K., and Prabhu, K.S. Inflammation, oxidative stress, and antioxidants. In “Chronic Inflammation: Nutritional & Therapeutic interventions." Eds. S. Roy, D. Bagchi, and S. P. Raychaudhuri. CRC Press (New York); Chapter 19, pp 259-273, 2012.
Kaushal, N., Gandhi, U. H., Nelson, S. M., Narayan, V., and Prabhu, K. S. 2011. Selenium and Inflammation. In Selenium: Its Molecular Biology and Role in Human Health 3rd Edition. Eds. D. Hatfield, M. Berry, V. N. Gladyshev, Springer Publications. Chapter 35, pp 443-456, 2012.
National Institutes of Health (NIDDK, NCI, NCCAM), American Institute of Cancer Research, Campbell Foundation, NIH CTSI- Penn State, NIH T32 (Animals models of inflammation), and College of Agricultural Sciences, Penn State Cancer Institute, Penn State University.
Svanjita Berry (Undergraduate Student)
Emily Finch, BS (Graduate Student- Immunology/Infectious Disease and CTSI Scholar)
James Frisbie, Undergrad Student (Schreyer's Honors College)
Chang Liao, MS (Graduate Student- Pathobiology)
Dr. K. Sandeep Prabhu, PhD (Principal Investigator; Professor)
Ashley Shay, BS (Graduate Student- Molecular Medicine and NIH T32 Trainee)
Jocelyn Stoudt, Undergraduate Student (Schreyer's Honors College)
Dr. Diwakar B. Tukaram, PhD (Post-doctoral Research Scholar)
Experimental Biology/ASN/ASBMB, Boston
Bioactive Lipids in Cancer, Inflammation, and Related Diseases (Eicosanoid Research Foundation)
American Institute for Cancer Research, Washington, D.C.
International Symposium on Host-Pathogen Interactions, University of Hyderabad and National Institute of Animal Biotechnology, Hyderabad, India.
International Trace Element Society's Trace Elements in Man and Animals (TEMA)-15 meeting, Orlando, FL
Experimental Biology (American Soc of Nutrition), Boston
International Symposium on Bioactive Lipids in Cancer, Inflammation, and Other Related Diseases, San Yuan, Puerto Rico (Travel award for Dr. Avinash Kudva from NIEHS/NIH; Travel Award for Emily Finch from Clinical Translational Sciences Institute, Penn State)
International Symposium on Selenium in Biology and Medicine, Berlin, Germany
Experimental Biology, San Diego, CA
AICR, Washington, D. C.
Experimental Biology, Washington, D. C.
Eicosanoid Research Foundation, Seattle, WA
Trace Element Society Meeting, TEMA-14, Enshi, China
AICR Meeting, Washington, D. C.
Experimental Biology 2010, Anaheim, CA- Shakira Nelson, Recipient of the ASBMB Graduate Travel Award
Graduate Exhibition, Penn State University
International Symposium on Selenium in Biology and Medicine- Kyoto, Japan
FASEB Summer Research Conference- Snowmass Village, Colorado
AICR Food, Nutrition, and Cancer Conference, Washington, D.C.
Experimental Biology 2009 (Recipients of the ASBMB Graduate Student Travel Awards: Ujjawal Gandhi and Vivek Narayan)
Eicosanoid Research Foundation 2009 (Cancun, Mexico)
Honors and Awards
Emily Finch- AICR Travel Award
Ashley Shay- T32 Trainee Award
Dr. Avinash Kudva- Travel Award- Eicosanoid research foundation meeting, San Yuan, PR
Dr. Naveen Kaushal- Travel Award- International Selenium Symposium, Berlin
Emily Finch, NIH Penn State-CTSI Award
Dr. Shakira Nelson, NCI Post-doctoral Research Fellowship Award
Dr. Vivek Narayan, ASBMB Travel Award
Dr. Ujjawal Gandhi, ASBMB Travel Award
Dr. Shakira Nelson, ASBMB Travel Award
Dr. Avinash Kudva, PhD (Post-doctoral Research Scholar); Current position: Research Asst. Professor; Mangalore University, India
Hunter Fraker Undergrad Student (Schreyer Honors College); Current position: MD Student, George Washington University, Washington, D.C.
Dr. Vivek Narayan, PhD (Graduate Student); Current position: Post-doctoral Scholar, MGH-Harvard Medical School and Boston Children's Hospital.
Dr. Naveen Kaushal, PhD (Post-doctoral Research Scholar); Current position: Assistant Professor, Department of Biophysics, Panjab University, Chandigarh, India.
Nicole Wilski, BS (Undergrad Student); Current position: Graduate Student; Thomas Jefferson University - Microbiology & Immunology Program
Dr. Shakira Nelson (Graduate Student- Pathobiology); Current position: CPFP Post-doctoral Fellow, NCI, Bethesda
Sara Farwell (BS Student); Current position: Graduate Student, Lehigh University
Steven Cornelius (BS Honors Student); Current position: MD Student, Penn State Hershey College of Medicine
Kayleigh McCormick (BS Honors Student); Current position: DVM Student, UPENN
Dr. Ujjawal H. Gandhi, M.B.,B.S. PhD (PhD Molecular Toxicology); Current position: Chief Medical Resident, Mt Sinai Hospital, NYC
Dr. Tejo Nagaraja, PhD DBT-CREST Visting Professor; Current position: Professor, Thapar University, India.
Dr. Uma Palempalli, DBT-CREST Visiting Professor; Current position: Professor, SV University for Women, Tirupati, India.
Dr. Ravindra C. Kodihalli (Post-doctoral Scholar); Current position: MIT, Cambridge
Dr. Anil Kotha, PhD (Post-doctoral Scholar); Current position: UT San Antonio, TX
Kelsey Hafer (BS Schreyer's Honors Student); Current position: Veterinarian, Women's Humane Society- Animal Hospital, Bensalem, PA
Amanda Tuchinsky (BS Schreyer's Honors Student);Current position: MD Student, Jefferson Med School
Prof. P. Reddanna, Professor and Dean- School of Life Sciences, University of Hyderabad, India
Pranav Maddali, BS (Research Tech); Current position: PhD Student; RPI- Albany, NY
Dr. Christopher Chiaro, PhD (Post-doctoral Research Scholar)Current position: Post-doc, Patterson Lab- Metabolomics Core; Penn State
Dr. Ryan J. Arner, PhD (Research Associate); Current position: DETRA-PSU Program Staff
Dr. Parisa Kalantari (Post-doc); Currently: Research Assistant Professor, Tufts University, Boston, MA
Pradeep Bodumalla (MS-Pathobiology); Current position: Unknown
Dr. Hema Vunta (PhD-Pathobiology) Currently: Lecturer, College of Pharmacy, Cincinnati, OH
Dr. K. Muralidhar (Visiting Professor) Current position: Professor of Zoology, University of Delhi, India
Stephanie Larson (MS- Pathobiology) Current position: Physician-Emergency Medicine, Erie, PA
Jessica Stahle (BS- Honors) Current position:Resident in Radiology, Department of Small Animal Clinical Science, Virgnia-Maryland College of Veterinary Medicine
Deepa Bhat (BS Honors) Current position: Senior Product Manager, Genentech
Katie Miro (BS Honors) Currently: Physician- Internal Med, Bellevue Hospital Ctr, NYC
- Immunology and Infectious Disease Research Faculty
Regulation of immune function by oxidative stress and antioxidants, including selenium. Regulation of HIV transcription by selenium.
- Molecular Toxicology & Carcinogenesis Research Faculty
Regulation of immune function by oxidative stress and antioxidants, including selenium. Regulation of HIV transcription by selenium.