K. Sandeep Prabhu, PhD
- Ph.D., Biochemistry, VMSRF-University of Mysore , India
- M.Sc., Biochemistry, University of Mysore , India
- B.Sc., Biochemistry, Botany & Zoology, University of Mysore , India
Emily Finch, BS (Graduate Student- Immunology/Infectious Disease and CTSI Scholar)
Hunter Fraker Undergrad Student (Schreyer Honors College)
James Frisbie, Undergrad Student (Schreyer Honors College)
Dr. Avinash Kudva, PhD (Post-doctoral Research Scholar)
Chang Liao, MS (Graduate Student- Pathobiology)
Erica Mellinger, Undergraduate Student (Schreyer Honors College)
Dr. K. Sandeep Prabhu, PhD (Principal Investigator; Professor)
Ashley Shay, BS (Graduate Student- Molecular Medicine and NIH T32 Trainee)
Jocelyn Stoudt, Undergraduate Student (Schreyer Honors College)
Dr. Vivek Narayan, PhD (Graduate Student); Current position: Post-doctoral Scholar, MGH-Harvard Medical School and Boston Children's Hospital.
Dr. Naveen Kaushal, PhD (Post-doctoral Research Scholar); Current position: Assistant Professor, Department of Biophysics, Panjab University, Chandigarh, India.
Nicole Wilski, BS (Undergrad Student); Current position: Graduate Student; Thomas Jefferson University - Microbiology & Immunology ProgramDr. Shakira Nelson (Graduate Student- Pathobiology); Current position: CPFP Post-doctoral Fellow, NCI, Bethesda (http://dceg.cancer.gov/fellowship-training/what-our-fellows-do/meet-current-fellows/neb-fellows
Sara Farwell (BS Student); Current position: Graduate Student, Lehigh University
Steven Cornelius (BS Honors Student); Current position: MD Student, Penn State Hershey College of Medicine
Kayleigh McCormick (BS Honors Student); Current position: DVM Student, UPENN
Dr. Ujjawal H. Gandhi, M.B.,B.S. PhD (PhD Molecular Toxicology); Current position: Chief Medical Resident, Mt Sinai Hospital, NYC
Dr. Tejo Nagaraja, PhD DBT-CREST Visting Professor; Current position: Professor, Thapar University, India.
Dr. Uma Palempalli, DBT-CREST Visiting Professor; Current position: Professor, SV University for Women, Tirupati, India.
Dr. Ravindra C. Kodihalli (Post-doctoral Scholar); Current position: MIT, Cambridge
Dr. Anil Kotha, PhD (Post-doctoral Scholar); Current position: UT San Antonio, TX
Kelsey Hafer (BS Schreyer's Honors Student); Current position: DVM Student, U Penn
Amanda Tuchinsky (BS Schreyer's Honors Student);Current position: MD Student, Jefferson Med School
Pranav Maddali, BS (Research Tech); Current position: PhD Student; RPI- Albany, NY
Dr. Christopher Chiaro, PhD (Post-doctoral Research Scholar)Current position: Post-doc, Patterson Lab- Metabolomics Core; Penn State
Dr. Ryan J. Arner, PhD (Research Associate); Current position: DETRA-PSU Program Staff
Dr. Parisa Kalantari (Post-doc) Currently: Post-doc @ UMass, Worcester
Pradeep Bodumalla (MS-Pathobiology); Current position: Unknown
Dr. Hema Vunta (PhD-Pathobiology) Currently: Lecturer, College of Pharmacy, Cincinnati, OH
Dr. K. Muralidhar (Visiting Professor) Current position: Professor of Zoology, University of Delhi, India
Stephanie Larson (MS- Pathobiology) Currently DO Student-Lake Erie College of Osteopathic Medicine
Jessica Stahle (BS- Honors) Currently: DVM Student at U Penn
Deepa Bhat (BS Honors) Currently: Scientist, FBI
Katie Miro (BS Honors) Currently: MD student; Temple
VB SC 514 (NUTRN 514) Prostaglandins and Leukotrienes (Alternate Sp semester)
The course provides an in-depth coverage of how fatty acids are metabolized in eukaryotes by various enzymatic and non-enzymatic mechanisms. The course will emphasize on the physiological roles of these fatty acid oxidation products in general health, inflammation, and reproduction along with their cellular basis of action via receptor-dependent and -independent mechanisms. (3 Credits)
VB SC 451 Immunotoxicology of Drugs and Chemicals (Coordinator: Dr. Prabhu/Co-instructor: Dr. Na Xiong) (Fa semester)
The immunotoxicology course will focus primarily on the effects of environmental chemicals, therapeutics, and recreational drugs on the immune system. Immunomodulatory mechanisms will be examined at systemic, cellular and molecular levels. Discussions will include theory, principles, and methodology and key issues in immunotoxicology. (3 Credits)
VB SC 330 Introduction to Molecular Pharmacology (Coordinator: Dr. Adam Glick/Co-instructor: Dr. Prabhu) (Sp Semester)
Molecular interactions between drugs and their tissue receptors and possible modifications of drugs to target different receptors will be discussed. Drugs used to treat infectious disease, cardiovascular disease, immune modulators, and anti-cancer drugs will be examined for their molecular interactions. Students will understand the complexities of new drug design and development from the initial stages of laboratory development to final approval for use by the Food and Drug Administration. (3 Credits)
Current projects in the lab:
1. Effect of selenium on leukemia stem cells
2. Targeting leukemia using novel lipid mediators derived from n-3 and n-6 fatty acids
3. Redox-dependent changes in the immune cell metabolome
3. Effect of selenium and selenoproteins on gut inflammation with an emphasis on eicosanoid metabolism
4. Effect of host selenoproteins in helminth infection
5. Redox regulation of erythropoiesis
6. The role of selenoproteins in HIV1 transcription
Targeting of leukemia stem cells: In collaboration with Dr. Robert Paulson
Please see the video:
V. Narayan, R. C. Kodihalli, C. Liao, N. Kaushal, B. A. Carlson, and K. S. Prabhu (2014) Epigenetic regulation of inflammatory gene expression in macrophages by selenium. J. Nutr. Biochem. (In Press)
K. C. Nicolaou, P. Heretsch, A. ElMarrouni, C. R. Hale, K. K. Pulukuri, A. K. Kudva, V. Narayan, K. S. Prabhu (2014) Total synthesis of D12-prostaglandin J3- a highly potent and selective anti-leukemic agent. Angew. Chem. Aug 5. doi: 10.1002/anie.201404917. (Epub ahead of print)
U.H. Gandhi, N. Kaushal, S. Hegde, E. Finch, A.K. Kudva, M.J. Kennett, C. T. Jordan, R. F. Paulson, K. S. Prabhu (2014) Role of endogenous eicosanoids in the suppression of leukemia by selenium. Cancer Res. (In Press)
M. Vijay Kumar, K. S. Prabhu, C. J. Rogers (2014) The Microbiome and Obesity?An Established Risk for Certain Types of Cancer. The Cancer Journal (Accepted; in Press)
2013:Kudva, N. Kaushal, S. Mohinta, M. J. Kennett, A. August, R. F. Paulson, and K. S. Prabhu (2013) Stability, bioavailability, and hypersensitivity of omega-3 derived anti-leukemic D12-PGJ3. PLoS One Dec 2;8(12) e80622
U. H. Gandhi, T. P. Nagaraja, and K. S. Prabhu (2013) Selenoproteins and their role in oxidative stress and inflammation. Curr. Chem. Biol. 7; 1-9
Y-C. Chen, K. S. Prabhu, A. Mastro (2013) Is selenium a potential treatment for cancer metastasis? Nutrients 5; 1149-68.
Y-C. Chen, K. S. Prabhu*, A. Mastro* (2013) Dietary selenium supplementation modifies breast tumor growth and metastasis. Int. J. Cancer 133;2054-64.
M.R. Flock, C. J. Rogers, K. S. Prabhu, P. M. Kris-Etherton (2013) Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. Diabetes Metab. Res. Rev. 29; 431-45.
Kaushal N, Narayan V, Gandhi UH, Nelson SM, Kotha AK and Prabhu KS (2012). Inflammation, oxidative stress, and antioxidants. In “Chronic Inflammation: Nutritional & Therapeutic interventions”. Eds. S. Roy, D. Bagchi, and S. P. Raychaudhuri. CRC Press (New York); Chapter 19, pp 259-273.
B. Belda, J. T. Thompson, R. Sinha, K. S. Prabhu, and J. P. Vanden Heuvel (2012) The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF2a synthesis in adipocytes. Prostaglandins Other Lipid Mediat. [E-Pub ahead of print May 11, 2012].
Ravindra KC, Narayan V, Lushington GH, Peterson BR, Prabhu KS. Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ(12)-PGJ(2) through Covalent Binding to Cys(1438).Chem Res Toxicol. 2012 Feb 20;25(2):337-47.
Kaushal N, Gandhi UH, Nelson SM, Narayan V and Prabhu KS (2011). Selenium and Inflammation. In Selenium: Its Molecular Biology and Role in Human Health (2012) 3rd Edition. Springer Publications. Chapter 35, pp 443-456.
Hegde S, Kaushal N, Ravindra KC, Chiaro C, Hafer KT, Gandhi UH, Thompson JT, Vanden Heuvel JP, Kennett MJ, Hankey P, Paulson RF, Prabhu KS. Delta12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. Blood. 2011 Oct 3. [Epub ahead of print] PMID: 21967980 (Ney, P: News and Views, Blood, Dec 22, 2011)UH Gandhi, N Kaushal, KC Ravindra, S Hegde, SM Nelson, V Narayan, H Vunta, RF Paulson, KS Prabhu (2011) Selenoprotein-dependent Up-regulation of Hematopoietic Prostaglandin D2 Synthase in Macrophages Is Mediated through the Activation of Peroxisome Proliferator-activated Receptor (PPAR)g. J. Biol. Chem. 286:27471-82.
S. Nelson, X. Lei, and K. S. Prabhu (2011) Selenium status regulates the expression of alternative activation markers in macrophages. J. Nutr. [E-Pub ahead of print]
N. Kaushal, S. Hegde, R. F. Paulson, and K. S. Prabhu (2011) The regulation of erythropoiesis by selenium. Antiox. Redox Signal. 14:1403-12.
M. Ray, S Yu, C. B. Wilson, N. Kaushal, K. S. Prabhu, and P. Hankey (2011) Regulation of TLR4 signaling in macrophages by the Ron receptor tyrosine kinase and its ligand, MSP. J. Immunol. 185:7309-16.
V. Narayan, K.C. Ravindra, C. Chiaro, D. Carey, B. B. Aggarwal, A. J. Henderson, and K. S. Prabhu (2011) Celastrol inhibits tat-dependent human immunodeficiency virus (HIV) transcription and replication. J. Mol. Biol. 410(5):972-83.
D. Desai, N. Kaushal, R. J. Arner, U. H. Gandhi, C. D’Souza, K. El-Bayoumy, S. G. Amin, and K. S. Prabhu (2010) Evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib. Chem. Biol. Interact. 188:446-56.
Y-C Chen, D. Sosnoski, U. H. Gandhi, L. Novinger, K. S. Prabhu*, and A. M. Mastro* (2009 Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. Carcinogenesis. 30(11):1941-8 (*Corresponding authors)
D Jiang, C. Chiaro, P. Maddali, K.S. Prabhu, and D. G. Peterson (2009) Identification of hydroxycinnamic acid –maillard reaction products in low-moisture baking model systems. J. Agric. Food Chem. 57: 9932-43
Kalantari P, Narayan V, Henderson AJ, and Prabhu KS (2009) 15-deoxy-PGJ2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. FASEB J. March 19
Stahle JA, Vunta H, Reddy CC, and Prabhu KS (2009) Regulation of expression of apolipoprotein A-I by selenium status in hepatocytes. Eur. J. Nutr. March 18
Palempalli UD, Gandhi U, Kalantari P, Vunta H, Arner RJ, Narayan V, Ravindran A, and Prabhu KS (2009). Gambogic acid covalently modifies IkB-kinase-b subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kB in macrophages. Biochem. J. 419 (2): 401-409.
DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, and Omiecinski CJ (2009) Di(2-ehtylhexyl)phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant, CAR2. Mol. Pharmacol. Feb 11
Hendricks III GL, Hadley JA, Krzysik-Walker SM, Prabhu KS, Vasilatos-Younken R, Ramachandran R (2009) Unique profile of chicken adiponectin, a predominantly heavy molecular weight multimer, and relationship to visceral adiposity. Endocrinology. March 19
Desai A, Konda VR, Darland G, Austin M, Prabhu KS, Bland J, Caroll B, and Tripp ML (2009) META060 inhibits multiple kinases in the NF-kB pathway and suppresses LPS-mediated inflammation in-vitro and in-vivo. Inflamm. Res. January
Kalantari P, Narayan V, Natarajan SK, Muralidhar K, Gandhi UH, Vunta H, Henderson AJ, Prabhu KS. Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein Tat-dependent transcription in human macrophages. J Biol Chem. 2008 Oct 3. [Epub ahead of print] PMID: 18835810 [PubMed - as supplied by publisher]
Vunta H, Belda BJ, Arner RJ, Channa Reddy C, Vanden Heuvel JP, Sandeep Prabhu K. Selenium attenuates pro-inflammatory gene expression in macrophages. Mol Nutr Food Res. 2008 May 15. [Epub ahead of print] PMID: 18481333 [PubMed - as supplied by publisher]
Chiaro CR, Morales JL, Prabhu KS, Perdew GH. Leukotriene A4 metabolites are endogenous ligands for the Ah receptor.Biochemistry. 2008 Aug 12;47(32):8445-55. Epub 2008 Jul 11. PMID: 18616291 [PubMed - indexed for MEDLINE]
NIH (NIDDK, NCI, NCCAM), AICR, Campbell Foundation, NIH CTSI- Penn State, NIH T32 (Animals models of inflammation), and College of Ag Sci, Penn State Cancer Institute, Penn State University
Experimental Biology/ASN/ASBMB, Boston
Bioactive Lipids in Cancer, Inflammation, and Related Diseases (Eicosanoid Research Foundation)
American Institute for Cancer Research, Washington, D.C.
International Symposium on Host-Pathogen Interactions, University of Hyderabad and National Institute of Animal Biotechnology, Hyderabad, India.
International Trace Element Society's Trace Elements in Man and Animals (TEMA)-15 meeting, Orlando, FL
Experimental Biology (American Soc of Nutrition), Boston
International Symposium on Bioactive Lipids in Cancer, Inflammation, and Other Related Diseases, San Yuan, Puerto Rico (Travel award for Dr. Avinash Kudva from NIEHS/NIH; Travel Award for Emily Finch from Clinical Translational Sciences Institute, Penn State)
International Symposium on Selenium in Biology and Medicine, Berlin, Germany
Experimental Biology, San Diego, CA
AICR, Washington, D.C.
Experimental Biology, Washington, D. C.
Eicosanoid Research Foundation, Seattle, WA
Trace Element Society Meeting, TEMA-14, Enshi, China
AICR Meeting, Washington, D. C.
Experimental Biology 2010, Anaheim, CA- Shakira Nelson, Recipient of the ASBMB Graduate Travel Award
Graduate Exhibition, Penn State University
International Symposium on Selenium in Biology and Medicine- Kyoto, Japan
FASEB Summer Research Conference- Snowmass Village, Colorado
AICR Food, Nutrition, and Cancer Conference, Washington, D.C.
Experimental Biology 2009 (Recipients of the ASBMB Graduate Student Travel Awards: Ujjawal Gandhi and Vivek Narayan)
Eicosanoid Research Foundation 2009 (Cancun, Mexico)
Honors and Awards:
Emily Finch- AICR Travel Award, 2014
Ashley Shay- T32 Trainee Award
Dr. Avinash Kudva- Travel Award- Eicosanoid research foundation meeting, San Yuan, PR
Naveen Kaushal- Travel Award- International Selenium Symposium, Berlin
Emily Finch, NIH Penn State-CTSI Award
Shakira Nelson, NCI Post-doctoral Research Fellowship Award
Vivek Narayan, ASBMB Travel Award
Ujjawal Gandhi, ASBMB Travel Award
Shakira Nelson, ASBMB Travel Award
- Immunology and Infectious Disease Research Faculty
Regulation of immune function by oxidative stress and antioxidants, including selenium. Regulation of HIV transcription by selenium.
- Molecular Toxicology & Carcinogenesis Research Faculty
Regulation of immune function by oxidative stress and antioxidants, including selenium. Regulation of HIV transcription by selenium.