Posted: February 26, 2019
Many enveloped viruses employ late domains such as PPXY to recruit the host ESCRT machinery needed for budding and particle release. Paramyxoviruses typically lack late domain sequences, yet budding of these viruses is often ESCRT-dependent. Here, Dr. Anthony Schmitt and Colleagues provide evidence for a model in which paramyxoviruses use AMOTL1 protein as a linker to indirectly recruit the same WW domain-containing NEDD4 ubiquitin ligases for budding that other enveloped viruses recruit directly through PPXY late domains.
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