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Ki67 positive cells in early KRas driven lung lesion

Ki67 positive cells in early KRas driven lung lesion

2017

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. Blazanin N, Son J, Craig-Lucas AB, John CL, Breech KJ, Podolsky MA, Glick ABProc Natl Acad Sci U S A. 114: 9900-9905, 2017.

Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-RasG12V-Induced Squamous Tumors. Podolsky MA, Bailey JT, Gunderson AJ, Oakes CJ, Breech K, Glick ABCancer Immunol Res. 5:198-210, 2017.

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C motif) ligand 5 expression in keratinocytes and skin. Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH. Toxicol Sci. 2017

Estrogen modulates mesenchyme-epidermis interactions in the adult nipple. Wu HJ, Oh JW, Spandau DF, Tholpady S, Diaz J 3rd, Schroeder LJ, Offutt CD, Glick AB, Plikus MV, Koyama S, Foley J. Development. 144:1498-1509, 2017

 

2015

Genetic and Pharmacological Analysis Identifies a Physiological Role for the AHR in Epidermal Differentiation.  van den Bogaard E., Podolsky M., Smits J., Cui X., John C., Gowda K, Desai D, Amin S, Schalkwijk J, Perdew G.H., and Glick A.B. J Invest Dermatol. 135:1320-8, 2015.  PMID:25602157.

2014

The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. Zhu B., Ferry C.H, Markell L.K, Blazanin N, Glick A.B, Gonzalez F.J, and Peters J.M.  J. Biol Chem. 289:20102-19, 2014 PMID: 24898257.

Tumor Promoting Role of TGFβ1 Signaling in Ultraviolet B-Induced Skin Carcinogenesis is Associated with Cutaneous Inflammation and Lymph Node Migration of Dermal Dendritic Cells. Ravindran A., Mohammed J., Gunderson A., Cui X., and Glick A.B. Carcinogenesis. 2014 35:959-66. PMID:243630.

PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling. Zhu B., Ferry C.H., Blazanin N., Bility M.T., Khozoie C., Kang B.H., Glick A.B., Gonzalez F.J., and Peters J.M. Oncogene. 2013 doi: 10.1038/onc.2013.477. PMID:24213576.

2013

Narola J., Pandey S.N., Glick A., Chen Y.W. Conditional Expression of TGF-β1 in Skeletal Muscles Causes Endomysial Fibrosis and Myofibers Atrophy. PLoS One. 2013 8:e79356. doi: 10.1371/journal.pone.0079356. PMID: 24244485.

The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes. Hogan K.A, Ravindran A., Podolsky M.A. and Glick A.B. Cytokine. 64:652-9, 2013. PMID:2075100.

CD8+ T cells Mediate RAS-induced Psoriasis-like Skin Inflammation Through IFN-γ. Gunderson A.J., Mohammed, J., Horvath, F., Podolsky, M.A., Anderson, C. and Glick, A.B. J. Invest. Dermatol. 133:955-63. PMID: 23151849

TGFβ1 Overexpression by Keratinocytes Alters Skin Dendritic Cell Homeostasis and Enhances Contact Hypersensitivity. Mohammed J., Gunderson A.J., Khong H.H., Koubek R.D., Udey M.C. and Glick A.B. J. Invest. Dermatol. 133:135-43, 2013. PMID: 22832490.

2012

The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models. Glick A.B. J. Skin Cancer. 2013 Epub 2012 Dec 26 PMID:23326666.

S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Shi C, Cooper T.K., McCloskey D.E., Glick A.B., Shantz L.M., Feith D.J. Carcinogenesis. 33:1310-8, 2012. PMID: 22610166

Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth. Plichta K.A., Mathers J.L., Gestl S.A., Glick A.B., and Gunther E.J. Cancer Research. 72:5856-66, 2012. PMID:23010075

Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells. Zhu B., Khozoie C., Bility M.T., Ferry C.H., Blazanin N., Glick A.B., Gonzalez F.J., and Peters J.M. Mol Cell Biol. 32:2065-82, 2012. PMID:22473992

A new xenotransplantation model reveals tumor initiating cells in cutaneous SCC. Glick, A. B.  J. Invest. Dermatol. 132:261-22012. 2012 

2011

Pharmacological Inhibition of ALK5 Causes Selective Induction of Terminal Differentiation in Mouse Keratinocytes Expressing Oncogenic HRAS. Markell, L.M., Masiuk, K.E., Blazanin, N. and Glick A.B. Mol. Cancer Res. 9:746-56, 2011. PMID: 21521744.

2010

Transforming growth factor β1 enhances tumor promotion in mouse skin carcinogenesis. Perez-Lorenzo, R., Mordasky Markell, L., Hogan, K. A., Yuspa, S.H and Glick, A.B. Carcinogenesis 31:1116-23, 2010.  PMID:20172950.

TGFβ1 induced inflammation in premalignant epidermal squamous lesions requires IL-17. Mohammed, J. Ryscavage, A., Perez-Lorenzo, R., Gunderson, A., Blazanin, N. and Glick, A.B. J. Invest. Dermatol. 130:2295-303, 2010. PMID:20410912.

Use of a TGFβ1 Type I Receptor Inhibitor in Mouse Skin Carcinogenesis Reveals a Dual Role for TGFβ1 Signaling in Tumor Promotion and Progression. Markell L.M, Pérez-Lorenzo R., Masiuk K.E., Kennett M.J., and Glick A.B. Carcinogenesis. 31:2127-35, 2010.  PMID: 20852150.

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