The purpose of this research is to examine the effects of diets high in certain fatty acids and bioactive molecules (pistachio nuts, peanuts, walnuts, fish oil, lean beef for example) to evaluate their effects on multiple cardiovascular disease (CVD) risk factors.

These risk factors include lipids and lipoproteins, apolipoproteins, oxidation, inflammation, insulin, glucose, blood pressure, endothelial health, and genetic expression of various genes. We propose that increasing the dietary intact of ω3-PUFAs in the context of a healthy diet, will improve CVD risk factors. These hypothesis are tested using cell culture and molecular biology techniques as well as clinical trials.

Example 1. Molecular Nutrition
Example 2. Clinical Nutrition
Article: Nuclear Receptors as Nutriable Targets

How nuclear receptors may represent potential targets of omega-3 polyunsaturated fatty acids (PUFAs) that can help explain their mechanism of action in preventing cardiovascular disease (CVD).

Penn State Center for Nutrigenomics

From table to the gene and back again

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