"To Be Announced"
Date and Location
When (Date/Time)March 15, 2017, 11:00 AM - 12:00 PM
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Amino acid control of protein synthesis and gene expression
My laboratory explores the cellular mechanisms triggered by altered amino acid availability delivered by diet, drug or genetic alteration. Alterations in amino acid supply are sensed by a number of overlapping signal transduction cascades. Two major signaling nodes responsive to amino acid supply are the general amino acid control/amino acid response (AAR) pathway and the mammalian target of rapamycin complex 1 (mTORC1) pathway. While the mTORC1 pathway is responsive to amino acid sufficiency and supplementation, the AAR is activated by amino acid insufficiency and deprivation. How these signaling pathways work together to maintain homeostasis by regulating global protein synthesis and gene-specific translation is a major research focus of the lab.