“Redox-Control of Inflammation Through Ca2+ and Thiol Signaling”.

Juan Andres “Andre” Melendez Professor & Associate Head Nanobioscience Constellation Colleges of Nanoscale Science & Engineering SUNY Polytechnic Institute

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September 20, 2017, 11:00 AM - 12:00 PM

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Our studies revolve around a key central paradigm, that oxidant signaling is precise, compartmentalized and amenable to targeted‐antioxidant based therapies. Reactive oxygen and nitrogen species (ROS/RNS), in addition to their ability to damage biomolecules, have also emerged as key mediators in regulation of signaling networks by modulating phosphatase activity, kinase cascades and transcription factor binding. Thus, ROS/RNS serve a dual role, at low concentrations they are secondary signaling molecules that regulate the expression of a wide array of signaling networks, and at high concentrations damage lipids, protein and DNA. The principle mediator of ROS‐dependent signaling is the 2e‐ reduction product of oxygen, H2O2, which is produced in response to numerous physiologic stimuli. Recent work from my lab and others indicate that superoxide (O2‐•) may also play an important role in cellular signal regulation.

Our work is focused on defining how ROS/RNS drive cellular signaling events that control metastatic disease, matrix destruction and the virulence of infectious bacteria. We have developed many cutting edge tools to monitor oxidant production from cells in real time. These assays are still fairly labor intensive and require a great deal of both biochemical and molecular expertise. CNSE technologies are being applied to develop nano-devices to assess cellular redox state. We are also performing high throughput screening (HTS) for agents that restrict age associated matrix destruction. Lastly our group is developing targeted‐antioxidant based therapeutics to be released at sites of matrix degradation. Our studies indicate that aberrant proteolysis is commonly linked to augmented free radical production that initiate or drive disease associated matrix destruction. Development of antioxidants that are released upon proteolysis at the precise site of oxidant production would then in turn ameliorate matrix destruction. CNSE is unique and provides the scientific infrastructure for the development of innovative therapeutic and diagnostic technologies to meet the medical demands of our aging population.

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