"Vitamin D and Cardiometabolic Disease: Lessons Known So Far"

Carlos Bernal-Mizrachi, M.D. Chief of Endocrinology at St. Louis VA Medical System Associate Professor Endocrinology, Metabolism and Lipid Research Washington University

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December 6, 2017, 11:30 AM - 12:30 PM

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Characterization of the effects of vitamin D deficiency on the development of metabolic syndrome and vascular complications

The long-term goal of our laboratory is to determine the mechanisms responsible for metabolic syndrome and its vascular complications. We are particularly interested in understanding the mechanisms of the interactions between vitamin D signal transduction, intracellular calcium, and endoplasmic reticulum stress in critical tissues responsible for the development of metabolic syndrome and its complications. We and others have shown that vitamin D treatment improves factors linked to vascular inflammation in patients with metabolic syndrome: it improves peripheral insulin action, suppresses the renin angiotensin system, decreases systemic inflammatory mediators, decreases macrophage cytokine release, and prevents macrophage cholesterol deposition by downregulation of endoplasmic reticulum stress. In our laboratory, we have generated mouse models of diet-induced vitamin D deficiency and engineered mice with altered vitamin D receptor and endoplasmic reticulum stress signaling in order to identify the role of this vitamin in different tissues involved in the development of metabolic syndrome and vascular inflammation.

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