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Dr. Adam Glick's Lab

Our research focus is on mechanisms of cancer development in squamous epithelia. We focus primarily on the role of Transforming Growth Factor Beta (TGFβ) and its signaling pathway in the regulation of tumor promotion and progression.

Non-melanoma skin cancer including both basal cell carcinoma and squamous cell carcinoma is the most frequent cancer among Caucasian populations, with incidence rates matching all other cancers combined in these groups. Although exposure to ultraviolet radiation from the sun is the major risk factor for cutaneous SCC, other risk factors also include chronic inflammation, and wounding, as well as exposure to arsenic, tobacco and coal tar products. The multistage mouse skin carcinogenesis model has been instrumental in defining the basic biology of squamous cell carcinoma (SCC) development in the skin and other epithelia.

Important News

Postdoctoral Position in Skin Cancer
July 25, 2016
Penn State Institutes of Energy and the Environment is seeking a postdoctoral researcher for a NIH funded postdoctoral position available starting September 1, 2016 in the Center for Molecular Toxicology and Carcinogenesis, Laboratory of Dr. Adam Glick. This position will focus on using mouse models of epithelial cancer including the skin to study the role of ER stress in the initial stages of cancer development and progression. Specifically the project will focus on the role of IRE1a and its downstream targets in the cellular response to oncogenic Ras. Applicants should have a Ph.D. in some aspect of Cancer Biology with expertise in molecular biology, animal models and cell biology of cancer and skin cancer. Ability/eligibility to apply for own funding is expected and encouraged. To apply, please upload a letter of interest describing current research and expertise along with C.V. This is a fixed-term appointment funded for one year from date of hire with the possibility of re-funding