Jonathan Harton, Albany Medical College

Talk Title: Immature Myeloid Cells, the Inflammasome, and IL-1: Finding Novel Paradigms in the Pathogenesis of Pulmonary Tularemia

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April 25, 2018, 11:00 AM - 12:00 PM

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Research in the Harton lab is focused on understanding the molecular regulation of immune responses.  A broad array of molecular, cellular, and in vivo approaches are employed to address questions relevant to innate immunity, inflammation, and cancer. Current work in the laboratory focuses on the molecular and cellular basis of the innate immune response to Francisella tularensis (a potential biowarfare agent), activation of the NLRP3 inflammasome, and regulation of inflammatory signal pathways by Pyrin-only proteins (POPs). Additional interests include the function and role of the master transcriptional regulator of MHC class II genes, CIITA in cancer immunology and MHC class II signaling.

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