Marius Sudol: National University of Singapore

Talk Title: "Role of WW Domain Proteins In Hippo-YAP Mechanosensistive Pathway, Golabi Syndrome and Ebola Virus Egress”

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October 30, 2019, 11:00 AM - 12:00 PM

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Marius Sudol is a recently retired American molecular and cellular biologist. He earned his PhD degree in 1983 at The Rockefeller University in New York (NYC), where he worked on oncogenes and cancer signaling with a renowned virologist, Professor Hidesaburo Hanafusa. After a long tenure at The Rockefeller University, Marius Sudol has changed his academic affiliations to conduct research and teaching at first at the Mount Sinai School of Medicine in NYC, then at Geisinger Labs in Pennsylvania and most recently, for 5 years, in the National University of Singapore, in Asia.

 Among his most significant academic achievements is the identification of YAP oncogene and a modular protein domain that it harbors: known as the WW domain, plus the characterization of cognate ligands of the domain. Today, the WW domain is known to mediate critical signals in tumor suppressor networks, including the Hippo-YAP signaling pathway. The WW domain was validated by Nature via two syndromes caused by loss-of-function point mutations in the WW domain or its cognate ligand.  One of the syndromes is Golabi-Ito-Hall (GIH) syndrome of intellectual disability, which phenocopies severe autism. Via numerous ongoing collaborations Marius Sudol contributed to the understanding of signaling functions of WW domain proteins in GIH syndrome and in Hippo-YAP tumor suppressor pathway. He also advises his colleagues, world-wide, on mechano-properties of cancers cells to uncover novel therapeutic targets that could be used to control those cancers that are caused by deregulation of the Hippo-YAP pathway. Marius will remain active for the next two years as a member of Editorial Boards of Science Signaling, Oncogene and the Journal of Biological Chemistry, as an adjunct faculty at the Icahn School of Medicine at Mount Sinai in New York City.  His seminar on October 30th this year at Penn State, hosted by Professor Anthony Schmitt will be his last formal research seminar in the U.S.A.

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