The Center for Nutrigenomics has enjoyed success in publications, grants and symposia. Below are some of the more recent success stories.


Berryman, C.E., Preston, A.G., Karmally, W., Deckelbaum, R.J., and Kris-­‐Etherton, P.M. (2011). Effects of almond consumption on the reduction of LDL-­‐cholesterol: a discussion of potential mechanisms and future research directions. Nutr Rev 69, 171-­‐185.

Zhang, J., Cai, S., Peterson, B.R., Kris-­‐Etherton, P.M., and Vanden Heuvel, J.P. (2011). Development of a Cell-­‐Based, High-­Throughput Screening Assay for Cholesterol Efflux Using a Fluorescent Mimic of Cholesterol. Assay Drug Dev Technol 00, Apr;9(2):136-46. Epub 2010 Nov 4. PMID: 21050070 [PubMed - in process]


Belda, B.J., Lee, Y., and Vanden Heuvel, J.P. (2010). Conjugated linoleic acids and inflammation: isomer-­‐ and tissue-­‐specific responses. Clin. Lipidol. 5, 699-­‐717.

Gillies, P.J., and Kris-­‐Etherton, P.M. (2010). Opportunities and challenges in nutrigenetics/nutrigenomics: building industry-­‐academia partnerships. J Nutrigenet Nutrigenomics 3, 296-­‐304. Also: World Rev Nutr Diet. 2010;101:160-8. Epub 2010 Apr 30. Review. No abstract available. PMID: 20436262 [PubMed - indexed for MEDLINE]

Kay, C.D., Gebauer, S.K., West, S.G., and Kris-­‐Etherton, P.M. (2010). Pistachios increase serum antioxidants and lower serum oxidized-­‐LDL in hypercholesterolemic adults. J Nutr 140, 1093-­‐98.

Lee, Y., and Vanden Heuvel, J.P. (2010). Inhibition of macrophage adhesion activity by 9trans,11trans-­‐conjugated linoleic acid. J Nutr Biochem 21, 490-­‐97.

Skulas-­‐Ray, A.C., Kris-­‐Etherton, P.M., Harris, W.S., Vanden Heuvel, J.P., Wagner, P.R., and West, S.G. (2010). Dose-­ response effects of omega-­3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr , 93(2): 243-­‐ 252. PMID: 21159789 [PubMed - indexed for MEDLINE]


Lee, Y., Thompson, J.T., and Vanden Heuvel, J.P. (2009). 9E,11E-­‐Conjugated Linoleic Acid Increases Expression of the Endogenous Antiinflammatory Factor, Interleukin-­‐1 Receptor Antagonist, in RAW 264.7 Cells. J Nutr 139, 1861-­‐66.

Lee, Y., Thompson, J.T., de Lera, A.R., and Vanden Heuvel, J.P. (2009). Isomer-­‐specific effects of conjugated linoleic acid on gene expression in RAW 264.7. J Nutr Biochem 20, 848-­‐ 59, 859.e1-­‐5.

Vanden Heuvel, J.P. (2009). Cardiovascular Disease-­‐related Genes and Regulation by Diet. Curr Atheroscler Rep 11, 448-­‐455.

Velliquette, R.A., Gillies, P.J., Kris-­‐Etherton, P.M., Green, J.W., Zhao, G., and Vanden Heuvel, J.P. (2009). Regulation of human stearoyl-­‐CoA desaturase by omega-­‐3 and omega-­‐ 6 fatty acids: Implications for the dietary management of elevated serum triglycerides. J Clin Lipidol 3, 281-­‐88.

Velliquette, R.A., Gillies, P.J., Kris-­‐Etherton, P.M., Green, J.W., Zhao, G., and Vanden Heuvel, J.P. (2009). Regulation of human stearoyl-­‐CoA desaturase by omega-­‐3 and omega-­‐ 6 fatty acids: Implications for the dietary management of elevated serum triglycerides. J Clin Lipidol 3, 281-­88. Epub 2009 Jun 21. PMID: 21291825 [PubMed - in process]

Zhang, J., Kris-­‐Etherton, P.M., Thompson, J.T., and Vanden Heuvel, J.P. (2009). Effect of pistachio oil on gene expression of IFN-­‐induced protein with tetratricopeptide repeats 2: A biomarker of inflammatory response. Mol Nutr Food Res 54, 1-­‐10. Also: Mol Nutr Food Res. 2010 May;54 Suppl 1:S83-92. PMID: 20013886 [PubMed - indexed for MEDLINE]


Davis, P.A., Jenab, M., Vanden Heuvel, J.P., Furlong, T., and Taylor, S. (2008). Tree nut and peanut consumption in relation to chronic and metabolic diseases including allergy. J Nutr 138, 1757S-­‐762S.

Mattes, R.D., Kris-­‐Etherton, P.M., and Foster, G.D. (2008). Impact of peanuts and tree nuts on body weight and healthy weight loss in adults. J Nutr 138, 1741S-­‐45S.

Spaccarotella, K.J., Kris-­‐Etherton, P.M., Stone, W.L., Bagshaw, D.M., Fishell, V.K., West, S.G., Lawrence, F.R., and Hartman, T.J. (2008). The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr J 7, 13.

Vunta, H., Belda, B.J., Arner, R.J., Channa Reddy, C., Vanden Heuvel, J.P., and Sandeep Prabhu, K. (2008). Selenium attenuates pro-­‐inflammatory gene expression in macrophages. Mol Nutr Food Res 52, 1316-­‐323.


Dancu, M.B., Berardi, D.E., Vanden Heuvel, J.P., and Tarbell, J.M. (2007). Atherogenic Endothelial Cell eNOS and ET-­‐1 Responses to Asynchronous Hemodynamics are Mitigated by Conjugated Linoleic Acid. Ann Biomed Eng 35, 1111-­‐19.

Gebauer, S.K., Psota, T.L., and Kris-­‐Etherton, P.M. (2007). The diversity of health effects of individual trans fatty acid isomers. Lipids 42, 787-­‐799.

Johnson, G.H., Keast, D.R., and Kris-­‐Etherton, P.M. (2007). Dietary modeling shows that the substitution of canola oil for fats commonly used in the United States would increase compliance with dietary recommendations for fatty acids. J Am Diet Assoc 107, 1726-­‐734.

Zhao, G., Etherton, T.D., Martin, K.R., Gillies, P.J., West, S.G., and Kris-­‐Etherton, P.M. (2007). Dietary alpha-­‐linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. Am J Clin Nutr 85, 385-­‐391.


Griel, A.E., and Kris-­‐Etherton, P.M. (2006). Tree nuts and the lipid profile: a review of clinical studies. Br J Nutr 96 Suppl 2, S68-­‐S78.


West, S.G., Hecker, K.D., Mustad, V.A., Nicholson, S., Schoemer, S.L., Wagner, P., Hinderliter, A.L., Ulbrecht, J., Ruey, P., and Kris-­‐Etherton, P.M. (2005). Acute effects of monounsaturated fatty acids with and without omega-­‐3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia 48, 113-­‐122.

Yu-­‐Poth, S., Yin, D., Kris-­‐Etherton, P.M., Zhao, G., and Etherton, T.D. (2005). Long-­‐chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cells. J Nutr 135, 2541-­‐45.

Zhao, G., Etherton, T.D., Martin, K.R., Vanden Heuvel, J.P., Gillies, P.J., West, S.G., and Kris-­‐Etherton, P.M. (2005). Anti-­‐ inflammatory effects of polyunsaturated fatty acids in THP-­‐ 1 cells. Biochem Biophys Res Commun 336, 909-­‐917. PMID: 16169525 [PubMed - indexed for MEDLINE]


Kris-­‐Etherton, P.M., Hecker, K.D., and Binkoski, A.E. (2004). Polyunsaturated fatty acids and cardiovascular health. Nutr Rev 62, 414-­‐426.

Vanden Heuvel, J.P. (2004). Diet, fatty acids, and regulation of genes important for heart disease. Curr Atheroscler Rep 6, 432-­‐440.

Yu-­‐Poth, S., Yin, D., Zhao, G., Kris-­‐Etherton, P.M., and Etherton, T.D. (2004). Conjugated linoleic acid upregulates LDL receptor gene expression in HepG2 cells. J Nutr 134, 68-­‐71

Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ, Kris-Etherton PM. (2004). Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr. 2004 Nov;134(11):2991-7. PMID: 15514264 [PubMed - indexed for MEDLINE]


The PSU Center for Nutrigenomics was a major player in the development of the Summer Symposia Series in Molecular Biology. The 28th Summer Symposium in Molecular Biology, "Genes, Nutrition, and Physical Activity: Understanding Obesity from Conception and Beyond.", was held August 11-14, 2009 at Penn State's University Park Campus.