Conjugated Linoleic Acids (CLA) shows distinct isomer and tissue differences: Implication for use as a dietary supplement.

Conjugated linoleic acid (CLA) is a mixture of dietary fatty acids that has various beneficial effects including decreasing cancer, atherosclerosis, diabetes and inflammation in animal models. Some controversy exists on the specific isomers of CLA that are responsible for the benefits observed. Our studies demonstrate distinct isomer differences in gene expression by CLA and will have important ramifications for determining the potential therapeutic benefit of these dietary fatty acids in prevention of inflammation-­‐related diseases. [PMID: 17394083,18993052, 19656856, 19443195]